Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KANK2 (KN motif and ankyrin repeat domains 2)

Identity

Alias_namesMXRA3
ANKRD25
matrix-remodelling associated 3
ankyrin repeat domain 25
Alias_symbol (synonym)KIAA1518
Other aliasNPHS16
PPKWH
SIP
HGNC (Hugo) KANK2
LocusID (NCBI) 25959
Atlas_Id 56149
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 11164267 and ends at 11194590 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SPC24 (19p13.2) / KANK2 (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KANK2   29300
Cards
Entrez_Gene (NCBI)KANK2  25959  KN motif and ankyrin repeat domains 2
AliasesANKRD25; MXRA3; NPHS16; PPKWH; 
SIP
GeneCards (Weizmann)KANK2
Ensembl hg19 (Hinxton)ENSG00000197256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197256 [Gene_View]  ENSG00000197256 [Sequence]  chr19:11164267-11194590 [Contig_View]  KANK2 [Vega]
ICGC DataPortalENSG00000197256
TCGA cBioPortalKANK2
AceView (NCBI)KANK2
Genatlas (Paris)KANK2
WikiGenes25959
SOURCE (Princeton)KANK2
Genetics Home Reference (NIH)KANK2
Genomic and cartography
GoldenPath hg38 (UCSC)KANK2  -     chr19:11164267-11194590 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KANK2  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathKANK2 - 19p13.2 [CytoView hg19]  KANK2 - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000197256
Mapping of homologs : NCBIKANK2 [Mapview hg19]  KANK2 [Mapview hg38]
OMIM614610   616099   617783   
Gene and transcription
Genbank (Entrez)AB040951 AB284125 AK000011 AK002094 AK023332
RefSeq transcript (Entrez)NM_001136191 NM_001329451 NM_015493
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KANK2
Alternative Splicing GalleryENSG00000197256
Gene ExpressionKANK2 [ NCBI-GEO ]   KANK2 [ EBI - ARRAY_EXPRESS ]   KANK2 [ SEEK ]   KANK2 [ MEM ]
Gene Expression Viewer (FireBrowse)KANK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25959
GTEX Portal (Tissue expression)KANK2
Human Protein AtlasENSG00000197256-KANK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ63ZY3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ63ZY3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ63ZY3
Splice isoforms : SwissVarQ63ZY3
PhosPhoSitePlusQ63ZY3
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    KN_motif   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    KN_motif (PF12075)   
Domain families : Pfam (NCBI)pfam12796    pfam12075   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)KANK2
DMDM Disease mutations25959
Blocks (Seattle)KANK2
PDB (RSDB)4HBD    5YBV   
PDB Europe4HBD    5YBV   
PDB (PDBSum)4HBD    5YBV   
PDB (IMB)4HBD    5YBV   
Structural Biology KnowledgeBase4HBD    5YBV   
SCOP (Structural Classification of Proteins)4HBD    5YBV   
CATH (Classification of proteins structures)4HBD    5YBV   
SuperfamilyQ63ZY3
Human Protein Atlas [tissue]ENSG00000197256-KANK2 [tissue]
Peptide AtlasQ63ZY3
HPRD12463
IPIIPI00470559   IPI00760962   IPI00760928   IPI00383834   
Protein Interaction databases
DIP (DOE-UCLA)Q63ZY3
IntAct (EBI)Q63ZY3
FunCoupENSG00000197256
BioGRIDKANK2
STRING (EMBL)KANK2
ZODIACKANK2
Ontologies - Pathways
QuickGOQ63ZY3
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  protein binding  cytoplasm  cytoplasm  mitochondrion  apoptotic process  negative regulation of cell proliferation  negative regulation of cell proliferation  negative regulation of intracellular estrogen receptor signaling pathway  negative regulation of intracellular estrogen receptor signaling pathway  regulation of Rho protein signal transduction  negative regulation of programmed cell death  negative regulation of vitamin D receptor signaling pathway  negative regulation of vitamin D receptor signaling pathway  kidney epithelium development  glomerular visceral epithelial cell migration  negative regulation of G1/S transition of mitotic cell cycle  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  protein binding  cytoplasm  cytoplasm  mitochondrion  apoptotic process  negative regulation of cell proliferation  negative regulation of cell proliferation  negative regulation of intracellular estrogen receptor signaling pathway  negative regulation of intracellular estrogen receptor signaling pathway  regulation of Rho protein signal transduction  negative regulation of programmed cell death  negative regulation of vitamin D receptor signaling pathway  negative regulation of vitamin D receptor signaling pathway  kidney epithelium development  glomerular visceral epithelial cell migration  negative regulation of G1/S transition of mitotic cell cycle  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkKANK2
Atlas of Cancer Signalling NetworkKANK2
Wikipedia pathwaysKANK2
Orthology - Evolution
OrthoDB25959
GeneTree (enSembl)ENSG00000197256
Phylogenetic Trees/Animal Genes : TreeFamKANK2
HOGENOMQ63ZY3
Homologs : HomoloGeneKANK2
Homology/Alignments : Family Browser (UCSC)KANK2
Gene fusions - Rearrangements
Fusion : QuiverKANK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKANK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KANK2
dbVarKANK2
ClinVarKANK2
1000_GenomesKANK2 
Exome Variant ServerKANK2
ExAC (Exome Aggregation Consortium)ENSG00000197256
GNOMAD BrowserENSG00000197256
Varsome BrowserKANK2
Genetic variants : HAPMAP25959
Genomic Variants (DGV)KANK2 [DGVbeta]
DECIPHERKANK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKANK2 
Mutations
ICGC Data PortalKANK2 
TCGA Data PortalKANK2 
Broad Tumor PortalKANK2
OASIS PortalKANK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKANK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKANK2
Mutations and Diseases : HGMDKANK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KANK2
DgiDB (Drug Gene Interaction Database)KANK2
DoCM (Curated mutations)KANK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KANK2 (select a term)
intoGenKANK2
Cancer3DKANK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614610    616099    617783   
Orphanet23118   
DisGeNETKANK2
MedgenKANK2
Genetic Testing Registry KANK2
NextProtQ63ZY3 [Medical]
TSGene25959
GENETestsKANK2
Target ValidationKANK2
Huge Navigator KANK2 [HugePedia]
snp3D : Map Gene to Disease25959
BioCentury BCIQKANK2
ClinGenKANK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25959
Chemical/Pharm GKB GenePA162392581
Clinical trialKANK2
Miscellaneous
canSAR (ICR)KANK2 (select the gene name)
DataMed IndexKANK2
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKANK2
EVEXKANK2
GoPubMedKANK2
iHOPKANK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Feb 19 16:50:03 CET 2020
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