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KANK2 (KN motif and ankyrin repeat domains 2)

Identity

Alias_namesMXRA3
ANKRD25
matrix-remodelling associated 3
ankyrin repeat domain 25
Alias_symbol (synonym)KIAA1518
Other aliasPPKWH
SIP
HGNC (Hugo) KANK2
LocusID (NCBI) 25959
Atlas_Id 56149
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 11274943 and ends at 11308243 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SPC24 (19p13.2) / KANK2 (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KANK2   29300
Cards
Entrez_Gene (NCBI)KANK2  25959  KN motif and ankyrin repeat domains 2
AliasesANKRD25; MXRA3; PPKWH; SIP
GeneCards (Weizmann)KANK2
Ensembl hg19 (Hinxton)ENSG00000197256 [Gene_View]  chr19:11274943-11308243 [Contig_View]  KANK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197256 [Gene_View]  chr19:11274943-11308243 [Contig_View]  KANK2 [Vega]
ICGC DataPortalENSG00000197256
TCGA cBioPortalKANK2
AceView (NCBI)KANK2
Genatlas (Paris)KANK2
WikiGenes25959
SOURCE (Princeton)KANK2
Genetics Home Reference (NIH)KANK2
Genomic and cartography
GoldenPath hg19 (UCSC)KANK2  -     chr19:11274943-11308243 -  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KANK2  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblKANK2 - 19p13.2 [CytoView hg19]  KANK2 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIKANK2 [Mapview hg19]  KANK2 [Mapview hg38]
OMIM614610   616099   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001136191 NM_001329451 NM_015493
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KANK2
Cluster EST : UnigeneHs.744940 [ NCBI ]
CGAP (NCI)Hs.744940
Alternative Splicing GalleryENSG00000197256
Gene ExpressionKANK2 [ NCBI-GEO ]   KANK2 [ EBI - ARRAY_EXPRESS ]   KANK2 [ SEEK ]   KANK2 [ MEM ]
Gene Expression Viewer (FireBrowse)KANK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25959
GTEX Portal (Tissue expression)KANK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ63ZY3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ63ZY3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ63ZY3
Splice isoforms : SwissVarQ63ZY3
PhosPhoSitePlusQ63ZY3
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    KN_motif   
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    KN_motif (PF12075)   
Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam12075   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)KANK2
DMDM Disease mutations25959
Blocks (Seattle)KANK2
PDB (SRS)4HBD   
PDB (PDBSum)4HBD   
PDB (IMB)4HBD   
PDB (RSDB)4HBD   
Structural Biology KnowledgeBase4HBD   
SCOP (Structural Classification of Proteins)4HBD   
CATH (Classification of proteins structures)4HBD   
SuperfamilyQ63ZY3
Human Protein AtlasENSG00000197256
Peptide AtlasQ63ZY3
HPRD12463
IPIIPI00470559   IPI00760962   IPI00760928   IPI00383834   
Protein Interaction databases
DIP (DOE-UCLA)Q63ZY3
IntAct (EBI)Q63ZY3
FunCoupENSG00000197256
BioGRIDKANK2
STRING (EMBL)KANK2
ZODIACKANK2
Ontologies - Pathways
QuickGOQ63ZY3
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  protein binding  cytoplasm  mitochondrion  transcription, DNA-templated  apoptotic process  negative regulation of cell proliferation  negative regulation of intracellular estrogen receptor signaling pathway  negative regulation of programmed cell death  negative regulation of vitamin D receptor signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  protein binding  cytoplasm  mitochondrion  transcription, DNA-templated  apoptotic process  negative regulation of cell proliferation  negative regulation of intracellular estrogen receptor signaling pathway  negative regulation of programmed cell death  negative regulation of vitamin D receptor signaling pathway  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkKANK2
Atlas of Cancer Signalling NetworkKANK2
Wikipedia pathwaysKANK2
Orthology - Evolution
OrthoDB25959
GeneTree (enSembl)ENSG00000197256
Phylogenetic Trees/Animal Genes : TreeFamKANK2
HOVERGENQ63ZY3
HOGENOMQ63ZY3
Homologs : HomoloGeneKANK2
Homology/Alignments : Family Browser (UCSC)KANK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKANK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KANK2
dbVarKANK2
ClinVarKANK2
1000_GenomesKANK2 
Exome Variant ServerKANK2
ExAC (Exome Aggregation Consortium)KANK2 (select the gene name)
Genetic variants : HAPMAP25959
Genomic Variants (DGV)KANK2 [DGVbeta]
DECIPHER (Syndromes)19:11274943-11308243  ENSG00000197256
CONAN: Copy Number AnalysisKANK2 
Mutations
ICGC Data PortalKANK2 
TCGA Data PortalKANK2 
Broad Tumor PortalKANK2
OASIS PortalKANK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKANK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKANK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KANK2
DgiDB (Drug Gene Interaction Database)KANK2
DoCM (Curated mutations)KANK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KANK2 (select a term)
intoGenKANK2
Cancer3DKANK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614610    616099   
Orphanet23118   
MedgenKANK2
Genetic Testing Registry KANK2
NextProtQ63ZY3 [Medical]
TSGene25959
GENETestsKANK2
Huge Navigator KANK2 [HugePedia]
snp3D : Map Gene to Disease25959
BioCentury BCIQKANK2
ClinGenKANK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25959
Chemical/Pharm GKB GenePA162392581
Clinical trialKANK2
Miscellaneous
canSAR (ICR)KANK2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKANK2
EVEXKANK2
GoPubMedKANK2
iHOPKANK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:11:24 CET 2017

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