Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KANSL1 (KAT8 regulatory NSL complex subunit 1)

Identity

Alias_namesKIAA1267
KIAA1267
Alias_symbol (synonym)DKFZP727C091
MSL1v1
CENP-36
NSL1
Other aliasKDVS
hMSL1v1
HGNC (Hugo) KANSL1
LocusID (NCBI) 284058
Atlas_Id 54391
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 46029916 and ends at 46225374 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KANSL1 (17q21.31) / ARL17A (17q21.31)KANSL1 (17q21.31) / ARL17B (17q21.31)KANSL1 (17q21.31) / HAP1 (17q21.2)
KANSL1 (17q21.31) / LAYN (11q23.1)KANSL1 (17q21.31) / LRRC37A (17q21.31)KANSL1 (17q21.31) / LRRC37A2 (17q21.31)
KANSL1 (17q21.31) / MAPT (17q21.31)KANSL1 (17q21.31) / MBTD1 (17q21.33)KANSL1 (17q21.31) / ORMDL3 (17q12)
KANSL1 (17q21.31) / UNC45B (17q12)KAT6B (10q22.2) / KANSL1 (17q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Myeloid proliferations in Down syndrome


External links

Nomenclature
HGNC (Hugo)KANSL1   24565
Cards
Entrez_Gene (NCBI)KANSL1  284058  KAT8 regulatory NSL complex subunit 1
AliasesCENP-36; KDVS; KIAA1267; MSL1v1; 
NSL1; hMSL1v1
GeneCards (Weizmann)KANSL1
Ensembl hg19 (Hinxton)ENSG00000120071 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120071 [Gene_View]  chr17:46029916-46225374 [Contig_View]  KANSL1 [Vega]
ICGC DataPortalENSG00000120071
TCGA cBioPortalKANSL1
AceView (NCBI)KANSL1
Genatlas (Paris)KANSL1
WikiGenes284058
SOURCE (Princeton)KANSL1
Genetics Home Reference (NIH)KANSL1
Genomic and cartography
GoldenPath hg38 (UCSC)KANSL1  -     chr17:46029916-46225374 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KANSL1  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblKANSL1 - 17q21.31 [CytoView hg19]  KANSL1 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIKANSL1 [Mapview hg19]  KANSL1 [Mapview hg38]
OMIM610443   612452   
Gene and transcription
Genbank (Entrez)AB033093 AI253068 AK094946 AK291259 AK310569
RefSeq transcript (Entrez)NM_001193465 NM_001193466 NM_015443
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_032784 NT_167251 NT_187663
Consensus coding sequences : CCDS (NCBI)KANSL1
Cluster EST : UnigeneHs.648744 [ NCBI ]
CGAP (NCI)Hs.648744
Alternative Splicing GalleryENSG00000120071
Gene ExpressionKANSL1 [ NCBI-GEO ]   KANSL1 [ EBI - ARRAY_EXPRESS ]   KANSL1 [ SEEK ]   KANSL1 [ MEM ]
Gene Expression Viewer (FireBrowse)KANSL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284058
GTEX Portal (Tissue expression)KANSL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3B3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3B3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3B3
Splice isoforms : SwissVarQ7Z3B3
PhosPhoSitePlusQ7Z3B3
Domains : Interpro (EBI)NSL1    PEHE_dom   
Domain families : Pfam (Sanger)PEHE (PF15275)   
Domain families : Pfam (NCBI)pfam15275   
Domain families : Smart (EMBL)PEHE (SM01300)  
Conserved Domain (NCBI)KANSL1
DMDM Disease mutations284058
Blocks (Seattle)KANSL1
PDB (SRS)4CY1    4CY2   
PDB (PDBSum)4CY1    4CY2   
PDB (IMB)4CY1    4CY2   
PDB (RSDB)4CY1    4CY2   
Structural Biology KnowledgeBase4CY1    4CY2   
SCOP (Structural Classification of Proteins)4CY1    4CY2   
CATH (Classification of proteins structures)4CY1    4CY2   
SuperfamilyQ7Z3B3
Human Protein AtlasENSG00000120071
Peptide AtlasQ7Z3B3
HPRD11254
IPIIPI00384972   IPI00748004   IPI01020933   IPI00935783   IPI00982727   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3B3
IntAct (EBI)Q7Z3B3
FunCoupENSG00000120071
BioGRIDKANSL1
STRING (EMBL)KANSL1
ZODIACKANSL1
Ontologies - Pathways
QuickGOQ7Z3B3
Ontology : AmiGOhistone acetyltransferase complex  condensed chromosome kinetochore  protein binding  nucleus  nucleoplasm  nucleoplasm  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  histone acetyltransferase activity (H4-K16 specific)  MLL1 complex  
Ontology : EGO-EBIhistone acetyltransferase complex  condensed chromosome kinetochore  protein binding  nucleus  nucleoplasm  nucleoplasm  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  histone acetyltransferase activity (H4-K16 specific)  MLL1 complex  
NDEx NetworkKANSL1
Atlas of Cancer Signalling NetworkKANSL1
Wikipedia pathwaysKANSL1
Orthology - Evolution
OrthoDB284058
GeneTree (enSembl)ENSG00000120071
Phylogenetic Trees/Animal Genes : TreeFamKANSL1
HOVERGENQ7Z3B3
HOGENOMQ7Z3B3
Homologs : HomoloGeneKANSL1
Homology/Alignments : Family Browser (UCSC)KANSL1
Gene fusions - Rearrangements
Fusion : MitelmanKANSL1/ARL17A [17q21.31/17q21.31]  
Fusion : MitelmanKANSL1/ARL17B [17q21.31/17q21.31]  [t(17;17)(q21;q21)]  
Fusion : MitelmanKANSL1/LAYN [17q21.31/11q23.1]  [t(11;17)(q23;q21)]  
Fusion : MitelmanKANSL1/MBTD1 [17q21.31/17q21.33]  [t(17;17)(q21;q21)]  
Fusion : MitelmanKANSL1/ORMDL3 [17q21.31/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanKANSL1/UNC45B [17q21.31/17q12]  [t(17;17)(q12;q21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKANSL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KANSL1
dbVarKANSL1
ClinVarKANSL1
1000_GenomesKANSL1 
Exome Variant ServerKANSL1
ExAC (Exome Aggregation Consortium)KANSL1 (select the gene name)
Genetic variants : HAPMAP284058
Genomic Variants (DGV)KANSL1 [DGVbeta]
DECIPHERKANSL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKANSL1 
Mutations
ICGC Data PortalKANSL1 
TCGA Data PortalKANSL1 
Broad Tumor PortalKANSL1
OASIS PortalKANSL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDKANSL1
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch KANSL1
DgiDB (Drug Gene Interaction Database)KANSL1
DoCM (Curated mutations)KANSL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KANSL1 (select a term)
intoGenKANSL1
Cancer3DKANSL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610443    612452   
Orphanet22351    22350   
MedgenKANSL1
Genetic Testing Registry KANSL1
NextProtQ7Z3B3 [Medical]
TSGene284058
GENETestsKANSL1
Target ValidationKANSL1
Huge Navigator KANSL1 [HugePedia]
snp3D : Map Gene to Disease284058
BioCentury BCIQKANSL1
ClinGenKANSL1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD284058
Chemical/Pharm GKB GenePA142671604
Clinical trialKANSL1
Miscellaneous
canSAR (ICR)KANSL1 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKANSL1
EVEXKANSL1
GoPubMedKANSL1
iHOPKANSL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:39:07 CEST 2017

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