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KAT2A (lysine acetyltransferase 2A)

Identity

Other namesGCN5
GCN5L2
PCAF-b
hGCN5
HGNC (Hugo) KAT2A
LocusID (NCBI) 2648
Atlas_Id 40696
Location 17q21.2
Location_base_pair Starts at 40265129 and ends at 40273382 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KAT2A (17q21.2) / ACSM1 (16p12.3)KAT2A (17q21.2) / STAT5B (17q21.2)SUGCT (7p14.1) / KAT2A (17q21.2)
KAT2A 17q21.2 / STAT5B 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KAT2A   4201
Cards
Entrez_Gene (NCBI)KAT2A  2648  lysine acetyltransferase 2A
GeneCards (Weizmann)KAT2A
Ensembl hg19 (Hinxton)ENSG00000108773 [Gene_View]  chr17:40265129-40273382 [Contig_View]  KAT2A [Vega]
Ensembl hg38 (Hinxton)ENSG00000108773 [Gene_View]  chr17:40265129-40273382 [Contig_View]  KAT2A [Vega]
ICGC DataPortalENSG00000108773
TCGA cBioPortalKAT2A
AceView (NCBI)KAT2A
Genatlas (Paris)KAT2A
WikiGenes2648
SOURCE (Princeton)KAT2A
Genomic and cartography
GoldenPath hg19 (UCSC)KAT2A  -     chr17:40265129-40273382 -  17q21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KAT2A  -     17q21.2   [Description]    (hg38-Dec_2013)
EnsemblKAT2A - 17q21.2 [CytoView hg19]  KAT2A - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIKAT2A [Mapview hg19]  KAT2A [Mapview hg38]
OMIM602301   
Gene and transcription
Genbank (Entrez)AF029777 BC032743 BC039907 BC105977 DB497139
RefSeq transcript (Entrez)NM_021078
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)KAT2A
Cluster EST : UnigeneHs.463045 [ NCBI ]
CGAP (NCI)Hs.463045
Alternative Splicing GalleryENSG00000108773
Gene ExpressionKAT2A [ NCBI-GEO ]   KAT2A [ EBI - ARRAY_EXPRESS ]   KAT2A [ SEEK ]   KAT2A [ MEM ]
Gene Expression Viewer (FireBrowse)KAT2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2648
GTEX Portal (Tissue expression)KAT2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92830 (Uniprot)
NextProtQ92830  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92830
Splice isoforms : SwissVarQ92830 (Swissvar)
Catalytic activity : Enzyme2.3.1.48 [ Enzyme-Expasy ]   2.3.1.482.3.1.48 [ IntEnz-EBI ]   2.3.1.48 [ BRENDA ]   2.3.1.48 [ KEGG ]   
PhosPhoSitePlusQ92830
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    GNAT (PS51186)   
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    Bromodomain    Bromodomain_CS    GNAT_dom    Hist_acetylase_PCAF    PCAF_N   
Domain families : Pfam (Sanger)Acetyltransf_7 (PF13508)    Bromodomain (PF00439)    PCAF_N (PF06466)   
Domain families : Pfam (NCBI)pfam13508    pfam00439    pfam06466   
Domain families : Smart (EMBL)BROMO (SM00297)  
DMDM Disease mutations2648
Blocks (Seattle)KAT2A
PDB (SRS)1F68    1Z4R    3D7C   
PDB (PDBSum)1F68    1Z4R    3D7C   
PDB (IMB)1F68    1Z4R    3D7C   
PDB (RSDB)1F68    1Z4R    3D7C   
Structural Biology KnowledgeBase1F68    1Z4R    3D7C   
SCOP (Structural Classification of Proteins)1F68    1Z4R    3D7C   
CATH (Classification of proteins structures)1F68    1Z4R    3D7C   
SuperfamilyQ92830
Human Protein AtlasENSG00000108773
Peptide AtlasQ92830
HPRD03807
IPIIPI00306871   IPI00221199   
Protein Interaction databases
DIP (DOE-UCLA)Q92830
IntAct (EBI)Q92830
FunCoupENSG00000108773
BioGRIDKAT2A
STRING (EMBL)KAT2A
ZODIACKAT2A
Ontologies - Pathways
QuickGOQ92830
Ontology : AmiGOnuclear chromatin  in utero embryonic development  somitogenesis  neural tube closure  chromatin binding  transcription coactivator activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  protein binding  extracellular space  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  chromatin remodeling  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription factor binding  cell proliferation  H3 histone acetyltransferase activity  response to organic cyclic compound  viral process  histone deubiquitination  protein phosphatase binding  telencephalon development  metencephalon development  midbrain development  STAGA complex  positive regulation of cell projection organization  regulation of protein stability  response to nutrient levels  transcription factor TFTC complex  positive regulation of histone acetylation  multicellular organism growth  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  histone deacetylase binding  histone H3 acetylation  histone H4-K12 acetylation  histone acetyltransferase activity (H4-K12 specific)  histone H3-K14 acetylation  positive regulation of gene expression, epigenetic  intracellular distribution of mitochondria  cardiac muscle cell differentiation  cellular response to tumor necrosis factor  alpha-tubulin acetylation  mitotic spindle  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  cellular response to nerve growth factor stimulus  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInuclear chromatin  in utero embryonic development  somitogenesis  neural tube closure  chromatin binding  transcription coactivator activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  protein binding  extracellular space  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  chromatin remodeling  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription factor binding  cell proliferation  H3 histone acetyltransferase activity  response to organic cyclic compound  viral process  histone deubiquitination  protein phosphatase binding  telencephalon development  metencephalon development  midbrain development  STAGA complex  positive regulation of cell projection organization  regulation of protein stability  response to nutrient levels  transcription factor TFTC complex  positive regulation of histone acetylation  multicellular organism growth  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  histone deacetylase binding  histone H3 acetylation  histone H4-K12 acetylation  histone acetyltransferase activity (H4-K12 specific)  histone H3-K14 acetylation  positive regulation of gene expression, epigenetic  intracellular distribution of mitochondria  cardiac muscle cell differentiation  cellular response to tumor necrosis factor  alpha-tubulin acetylation  mitotic spindle  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  cellular response to nerve growth factor stimulus  positive regulation of transcription regulatory region DNA binding  
Pathways : KEGGNotch signaling pathway    Thyroid hormone signaling pathway    HTLV-I infection    Viral carcinogenesis   
NDEx Network
Atlas of Cancer Signalling NetworkKAT2A
Wikipedia pathwaysKAT2A
Orthology - Evolution
OrthoDB2648
GeneTree (enSembl)ENSG00000108773
Phylogenetic Trees/Animal Genes : TreeFamKAT2A
Homologs : HomoloGeneKAT2A
Homology/Alignments : Family Browser (UCSC)KAT2A
Gene fusions - Rearrangements
Fusion: TCGAKAT2A 17q21.2 STAT5B 17q21.2 BLCA
Polymorphisms : SNP, variants
NCBI Variation ViewerKAT2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KAT2A
dbVarKAT2A
ClinVarKAT2A
1000_GenomesKAT2A 
Exome Variant ServerKAT2A
ExAC (Exome Aggregation Consortium)KAT2A (select the gene name)
Genetic variants : HAPMAP2648
Genomic Variants (DGV)KAT2A [DGVbeta]
Mutations
ICGC Data PortalKAT2A 
TCGA Data PortalKAT2A 
Broad Tumor PortalKAT2A
OASIS PortalKAT2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKAT2A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KAT2A
DgiDB (Drug Gene Interaction Database)KAT2A
DoCM (Curated mutations)KAT2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KAT2A (select a term)
intoGenKAT2A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:40265129-40273382  ENSG00000108773
CONAN: Copy Number AnalysisKAT2A 
Mutations and Diseases : HGMDKAT2A
OMIM602301   
MedgenKAT2A
Genetic Testing Registry KAT2A
NextProtQ92830 [Medical]
TSGene2648
GENETestsKAT2A
Huge Navigator KAT2A [HugePedia]
snp3D : Map Gene to Disease2648
BioCentury BCIQKAT2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2648
Chemical/Pharm GKB GenePA162392664
Clinical trialKAT2A
Miscellaneous
canSAR (ICR)KAT2A (select the gene name)
Probes
Litterature
PubMed127 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKAT2A
EVEXKAT2A
GoPubMedKAT2A
iHOPKAT2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:51:26 CEST 2016

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