| Nomenclature |
|---|
| HGNC (Hugo) | KAT2B 8638 |
| Cards |
|---|
| Entrez_Gene (NCBI) | KAT2B lysine acetyltransferase 2B |
| Aliases | CAF; P/CAF; PCAF |
| GeneCards (Weizmann) | KAT2B |
| Ensembl hg19 (Hinxton) | ENSG00000114166 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000114166 [Gene_View] ENSG00000114166 [Sequence] chr3:20040446-20154404 [Contig_View] KAT2B [Vega] |
| ICGC DataPortal | ENSG00000114166 |
| TCGA cBioPortal | KAT2B |
| AceView (NCBI) | KAT2B |
| Genatlas (Paris) | KAT2B |
| SOURCE (Princeton) | KAT2B |
| Genetics Home Reference (NIH) | KAT2B |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | KAT2B - chr3:20040446-20154404 + 3p24.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | KAT2B - 3p24.3 [Description] (hg19-Feb_2009) |
| GoldenPath | KAT2B - 3p24.3 [CytoView hg19] KAT2B - 3p24.3 [CytoView hg38] |
| ImmunoBase | ENSG00000114166 |
| genome Data Viewer NCBI | KAT2B [Mapview hg19] |
| OMIM | 602303 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AL832173 BC060823 BC070075 U57317 |
| RefSeq transcript (Entrez) | NM_003884 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | KAT2B |
| Alternative Splicing Gallery | ENSG00000114166 |
| Gene Expression | KAT2B [ NCBI-GEO ] KAT2B [ EBI - ARRAY_EXPRESS ]
KAT2B [ SEEK ] KAT2B [ MEM ] |
| Gene Expression Viewer (FireBrowse) | KAT2B [ Firebrowse - Broad ] |
| Genevisible | Expression of KAT2B in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 8850 |
| GTEX Portal (Tissue expression) | KAT2B |
| Human Protein Atlas | ENSG00000114166-KAT2B [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q92831 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q92831 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q92831 |
| Splice isoforms : SwissVar | Q92831 |
| PhosPhoSitePlus | Q92831 |
| Domaine pattern : Prosite (Expaxy) | BROMODOMAIN_1 (PS00633) BROMODOMAIN_2 (PS50014) GNAT (PS51186) |
| Domains : Interpro (EBI) | Acyl_CoA_acyltransferase Bromodomain Bromodomain-like_sf Bromodomain_CS GCN5 GCN5/PCAF GNAT_dom PCAF_N |
| Domain families : Pfam (Sanger) | Acetyltransf_1 (PF00583) Bromodomain (PF00439) PCAF_N (PF06466) |
| Domain families : Pfam (NCBI) | pfam00583 pfam00439 pfam06466 |
| Domain families : Smart (EMBL) | BROMO (SM00297) |
| Conserved Domain (NCBI) | KAT2B |
| Blocks (Seattle) | KAT2B |
| PDB (RSDB) | 1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O |
| PDB Europe | 1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O |
| PDB (PDBSum) | 1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O |
| PDB (IMB) | 1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O |
| Structural Biology KnowledgeBase | 1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O |
| SCOP (Structural Classification of Proteins) | 1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O |
| CATH (Classification of proteins structures) | 1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O |
| Superfamily | Q92831 |
| Human Protein Atlas [tissue] | ENSG00000114166-KAT2B [tissue] |
| Peptide Atlas | Q92831 |
| HPRD | 06780 |
| IPI | IPI00022055 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q92831 |
| IntAct (EBI) | Q92831 |
| BioGRID | KAT2B |
| STRING (EMBL) | KAT2B |
| ZODIAC | KAT2B |
| Ontologies - Pathways |
|---|
| QuickGO | Q92831 |
| Ontology : AmiGO | PCAF complex kinetochore RNA polymerase II regulatory region sequence-specific DNA binding chromatin binding transcription coregulator activity transcription coactivator activity diamine N-acetyltransferase activity histone acetyltransferase activity histone acetyltransferase activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor lysine N-acetyltransferase activity, acting on acetyl phosphate as donor cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus nucleus nucleoplasm nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex centrosome chromatin remodeling chromatin remodeling transcription initiation from RNA polymerase II promoter protein acetylation cell cycle arrest Notch signaling pathway positive regulation of transcription of Notch receptor target heart development transcription factor binding negative regulation of cell proliferation regulation of protein ADP-ribosylation viral process acetyltransferase activity protein deubiquitination N-terminal peptidyl-lysine acetylation internal peptidyl-lysine acetylation peptidyl-lysine acetylation protein kinase binding A band I band cellular response to insulin stimulus protein-containing complex protein-containing complex actomyosin histone deacetylase binding histone H3 acetylation histone H3-K9 acetylation regulation of megakaryocyte differentiation positive regulation of gluconeogenesis negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of Notch signaling pathway positive regulation of gene expression, epigenetic positive regulation of transcription by RNA polymerase II negative regulation of centriole replication rhythmic process limb development peptide-lysine-N-acetyltransferase activity negative regulation of rRNA processing |
| Ontology : EGO-EBI | PCAF complex kinetochore RNA polymerase II regulatory region sequence-specific DNA binding chromatin binding transcription coregulator activity transcription coactivator activity diamine N-acetyltransferase activity histone acetyltransferase activity histone acetyltransferase activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor lysine N-acetyltransferase activity, acting on acetyl phosphate as donor cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding nucleus nucleus nucleoplasm nucleoplasm Ada2/Gcn5/Ada3 transcription activator complex centrosome chromatin remodeling chromatin remodeling transcription initiation from RNA polymerase II promoter protein acetylation cell cycle arrest Notch signaling pathway positive regulation of transcription of Notch receptor target heart development transcription factor binding negative regulation of cell proliferation regulation of protein ADP-ribosylation viral process acetyltransferase activity protein deubiquitination N-terminal peptidyl-lysine acetylation internal peptidyl-lysine acetylation peptidyl-lysine acetylation protein kinase binding A band I band cellular response to insulin stimulus protein-containing complex protein-containing complex actomyosin histone deacetylase binding histone H3 acetylation histone H3-K9 acetylation regulation of megakaryocyte differentiation positive regulation of gluconeogenesis negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of Notch signaling pathway positive regulation of gene expression, epigenetic positive regulation of transcription by RNA polymerase II negative regulation of centriole replication rhythmic process limb development peptide-lysine-N-acetyltransferase activity negative regulation of rRNA processing |
| Pathways : KEGG | Notch signaling pathway Thyroid hormone signaling pathway HTLV-I infection Viral carcinogenesis |
| NDEx Network | KAT2B |
| Atlas of Cancer Signalling Network | KAT2B |
| Wikipedia pathways | KAT2B |
| Orthology - Evolution |
|---|
| OrthoDB | 8850 |
| GeneTree (enSembl) | ENSG00000114166 |
| Phylogenetic Trees/Animal Genes : TreeFam | KAT2B |
| HOGENOM | Q92831 |
| Homologs : HomoloGene | KAT2B |
| Homology/Alignments : Family Browser (UCSC) | KAT2B |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | KAT2B |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | KAT2B [hg38] |
| dbVar | KAT2B |
| ClinVar | KAT2B |
| Monarch | KAT2B |
| 1000_Genomes | KAT2B |
| Exome Variant Server | KAT2B |
| GNOMAD Browser | ENSG00000114166 |
| Varsome Browser | KAT2B |
| Genomic Variants (DGV) | KAT2B [DGVbeta] |
| DECIPHER | KAT2B [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | KAT2B |
| Mutations |
|---|
| ICGC Data Portal | KAT2B |
| TCGA Data Portal | KAT2B |
| Broad Tumor Portal | KAT2B |
| OASIS Portal | KAT2B [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | KAT2B [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | KAT2B |
| Mutations and Diseases : HGMD | KAT2B |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search KAT2B |
| DgiDB (Drug Gene Interaction Database) | KAT2B |
| DoCM (Curated mutations) | KAT2B (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | KAT2B (select a term) |
| intoGen | KAT2B |
| Cancer3D | KAT2B(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602303 |
| Orphanet | |
| DisGeNET | KAT2B |
| Medgen | KAT2B |
| Genetic Testing Registry | KAT2B
|
| NextProt | Q92831 [Medical] |
| GENETests | KAT2B |
| Target Validation | KAT2B |
| Huge Navigator |
KAT2B [HugePedia] |
| ClinGen | KAT2B |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | KAT2B |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA162392705 |
| Pharos | Q92831 |
| Clinical trial | KAT2B |
| Miscellaneous |
|---|
| canSAR (ICR) | KAT2B (select the gene name) |
| Harmonizome | KAT2B |
| DataMed Index | KAT2B |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 374 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | KAT2B |
