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KAT7 (lysine acetyltransferase 7)

Identity

Alias_namesMYST2
MYST histone acetyltransferase 2
K(lysine) acetyltransferase 7
Alias_symbol (synonym)HBOA
HBO1
ZC2HC7
Other alias
HGNC (Hugo) KAT7
LocusID (NCBI) 11143
Atlas_Id 52346
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 49788619 and ends at 49829096 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / KAT7 (17q21.33)KAT7 (17q21.33) / AXIN2 (17q24.1)KAT7 (17q21.33) / IGF2BP1 (17q21.32)
BCAS3 17q23.2 / KAT7 17q21.33KAT7 17q21.33 / AXIN2 17q24.1KAT7 17q21.33 / IGF2BP1 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;22)(p13;q13) PAX5/BRD1


External links

Nomenclature
HGNC (Hugo)KAT7   17016
Cards
Entrez_Gene (NCBI)KAT7  11143  lysine acetyltransferase 7
AliasesHBO1; HBOA; MYST2; ZC2HC7
GeneCards (Weizmann)KAT7
Ensembl hg19 (Hinxton)ENSG00000136504 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136504 [Gene_View]  chr17:49788619-49829096 [Contig_View]  KAT7 [Vega]
ICGC DataPortalENSG00000136504
TCGA cBioPortalKAT7
AceView (NCBI)KAT7
Genatlas (Paris)KAT7
WikiGenes11143
SOURCE (Princeton)KAT7
Genetics Home Reference (NIH)KAT7
Genomic and cartography
GoldenPath hg38 (UCSC)KAT7  -     chr17:49788619-49829096 +  17q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KAT7  -     17q21.33   [Description]    (hg19-Feb_2009)
EnsemblKAT7 - 17q21.33 [CytoView hg19]  KAT7 - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBIKAT7 [Mapview hg19]  KAT7 [Mapview hg38]
OMIM609880   
Gene and transcription
Genbank (Entrez)AF074606 AF140360 AF217502 AK023890 AK122932
RefSeq transcript (Entrez)NM_001199155 NM_001199156 NM_001199157 NM_001199158 NM_001346706 NM_007067
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KAT7
Cluster EST : UnigeneHs.21907 [ NCBI ]
CGAP (NCI)Hs.21907
Alternative Splicing GalleryENSG00000136504
Gene ExpressionKAT7 [ NCBI-GEO ]   KAT7 [ EBI - ARRAY_EXPRESS ]   KAT7 [ SEEK ]   KAT7 [ MEM ]
Gene Expression Viewer (FireBrowse)KAT7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11143
GTEX Portal (Tissue expression)KAT7
Human Protein AtlasENSG00000136504-KAT7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95251   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95251  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95251
Splice isoforms : SwissVarO95251
PhosPhoSitePlusO95251
Domaine pattern : Prosite (Expaxy)MYST_HAT (PS51726)    ZF_CCHHC (PS51802)   
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    HAT_MYST-type    Znf_C2HC   
Domain families : Pfam (Sanger)MOZ_SAS (PF01853)    zf-C2HC (PF01530)   
Domain families : Pfam (NCBI)pfam01853    pfam01530   
Conserved Domain (NCBI)KAT7
DMDM Disease mutations11143
Blocks (Seattle)KAT7
SuperfamilyO95251
Human Protein Atlas [tissue]ENSG00000136504-KAT7 [tissue]
Peptide AtlasO95251
HPRD07135
IPIIPI00180764   IPI00909215   IPI00909397   IPI00953599   IPI00792061   IPI00964824   IPI00966972   
Protein Interaction databases
DIP (DOE-UCLA)O95251
IntAct (EBI)O95251
FunCoupENSG00000136504
BioGRIDKAT7
STRING (EMBL)KAT7
ZODIACKAT7
Ontologies - Pathways
QuickGOO95251
Ontology : AmiGOhistone acetyltransferase complex  DNA replication origin binding  transcription factor activity, sequence-specific DNA binding  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  DNA replication  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  stress-activated protein kinase signaling cascade  histone H3 acetylation  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K12 acetylation  histone H4-K16 acetylation  transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter  response to sorbitol  response to hydroxyurea  response to actinomycin D  response to dithiothreitol  response to anisomycin  positive regulation of histone H4 acetylation  positive regulation of protein localization to nucleus  
Ontology : EGO-EBIhistone acetyltransferase complex  DNA replication origin binding  transcription factor activity, sequence-specific DNA binding  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  DNA replication  transcription, DNA-templated  regulation of transcription, DNA-templated  zinc ion binding  stress-activated protein kinase signaling cascade  histone H3 acetylation  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K12 acetylation  histone H4-K16 acetylation  transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter  response to sorbitol  response to hydroxyurea  response to actinomycin D  response to dithiothreitol  response to anisomycin  positive regulation of histone H4 acetylation  positive regulation of protein localization to nucleus  
NDEx NetworkKAT7
Atlas of Cancer Signalling NetworkKAT7
Wikipedia pathwaysKAT7
Orthology - Evolution
OrthoDB11143
GeneTree (enSembl)ENSG00000136504
Phylogenetic Trees/Animal Genes : TreeFamKAT7
HOVERGENO95251
HOGENOMO95251
Homologs : HomoloGeneKAT7
Homology/Alignments : Family Browser (UCSC)KAT7
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/KAT7 [17q23.2/17q21.33]  [t(17;17)(q21;q23)]  
Fusion : MitelmanKAT7/AXIN2 [17q21.33/17q24.1]  [t(17;17)(q21;q24)]  
Fusion : MitelmanKAT7/IGF2BP1 [17q21.33/17q21.32]  [t(17;17)(q21;q21)]  
Fusion: TCGA_MDACCBCAS3 17q23.2 KAT7 17q21.33 BRCA
Fusion: TCGA_MDACCKAT7 17q21.33 AXIN2 17q24.1 BRCA
Fusion: TCGA_MDACCKAT7 17q21.33 IGF2BP1 17q21.32 THCA
Tumor Fusion PortalKAT7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKAT7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KAT7
dbVarKAT7
ClinVarKAT7
1000_GenomesKAT7 
Exome Variant ServerKAT7
ExAC (Exome Aggregation Consortium)ENSG00000136504
GNOMAD BrowserENSG00000136504
Genetic variants : HAPMAP11143
Genomic Variants (DGV)KAT7 [DGVbeta]
DECIPHERKAT7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKAT7 
Mutations
ICGC Data PortalKAT7 
TCGA Data PortalKAT7 
Broad Tumor PortalKAT7
OASIS PortalKAT7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKAT7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKAT7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KAT7
DgiDB (Drug Gene Interaction Database)KAT7
DoCM (Curated mutations)KAT7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KAT7 (select a term)
intoGenKAT7
Cancer3DKAT7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609880   
Orphanet
DisGeNETKAT7
MedgenKAT7
Genetic Testing Registry KAT7
NextProtO95251 [Medical]
TSGene11143
GENETestsKAT7
Target ValidationKAT7
Huge Navigator KAT7 [HugePedia]
snp3D : Map Gene to Disease11143
BioCentury BCIQKAT7
ClinGenKAT7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11143
Chemical/Pharm GKB GenePA134886407
Clinical trialKAT7
Miscellaneous
canSAR (ICR)KAT7 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKAT7
EVEXKAT7
GoPubMedKAT7
iHOPKAT7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:18:27 CET 2017

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