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KATNA1 (katanin catalytic subunit A1)

Identity

Alias_nameskatanin p60 (ATPase-containing) subunit A 1
katanin p60 (ATPase containing) subunit A 1
Other alias-
HGNC (Hugo) KATNA1
LocusID (NCBI) 11104
Atlas_Id 52633
Location 6q25.1  [Link to chromosome band 6q25]
Location_base_pair Starts at 149594875 and ends at 149648804 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FCRL1 (1q23.1) / KATNA1 (6q25.1)KATNA1 (6q25.1) / LATS1 (6q25.1)KATNA1 (6q25.1) / PPP2R1A (19q13.41)
PPIL4 (6q25.1) / KATNA1 (6q25.1)KATNA1 6q25.1 / LATS1 6q25.1KATNA1 6q25.1 / PPP2R1A 19q13.41

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  KATNA1/LATS1 (6q25)
t(6;19)(q25;q13) KATNA1/PPP2R1A


External links

Nomenclature
HGNC (Hugo)KATNA1   6216
Cards
Entrez_Gene (NCBI)KATNA1  11104  katanin catalytic subunit A1
Aliases
GeneCards (Weizmann)KATNA1
Ensembl hg19 (Hinxton)ENSG00000186625 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186625 [Gene_View]  ENSG00000186625 [Sequence]  chr6:149594875-149648804 [Contig_View]  KATNA1 [Vega]
ICGC DataPortalENSG00000186625
TCGA cBioPortalKATNA1
AceView (NCBI)KATNA1
Genatlas (Paris)KATNA1
WikiGenes11104
SOURCE (Princeton)KATNA1
Genetics Home Reference (NIH)KATNA1
Genomic and cartography
GoldenPath hg38 (UCSC)KATNA1  -     chr6:149594875-149648804 -  6q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KATNA1  -     6q25.1   [Description]    (hg19-Feb_2009)
EnsemblKATNA1 - 6q25.1 [CytoView hg19]  KATNA1 - 6q25.1 [CytoView hg38]
Mapping of homologs : NCBIKATNA1 [Mapview hg19]  KATNA1 [Mapview hg38]
OMIM606696   
Gene and transcription
Genbank (Entrez)AF056022 AK292090 BC050428 CA426364 DB031858
RefSeq transcript (Entrez)NM_001204076 NM_007044
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KATNA1
Cluster EST : UnigeneHs.450175 [ NCBI ]
CGAP (NCI)Hs.450175
Alternative Splicing GalleryENSG00000186625
Gene ExpressionKATNA1 [ NCBI-GEO ]   KATNA1 [ EBI - ARRAY_EXPRESS ]   KATNA1 [ SEEK ]   KATNA1 [ MEM ]
Gene Expression Viewer (FireBrowse)KATNA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11104
GTEX Portal (Tissue expression)KATNA1
Human Protein AtlasENSG00000186625-KATNA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75449   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75449  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75449
Splice isoforms : SwissVarO75449
PhosPhoSitePlusO75449
Domaine pattern : Prosite (Expaxy)AAA (PS00674)   
Domains : Interpro (EBI)AAA+_ATPase    ATPase_AAA_core    ATPase_AAA_CS    KATNA1    P-loop_NTPase    Vps4_C   
Domain families : Pfam (Sanger)AAA (PF00004)    Vps4_C (PF09336)   
Domain families : Pfam (NCBI)pfam00004    pfam09336   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)KATNA1
DMDM Disease mutations11104
Blocks (Seattle)KATNA1
SuperfamilyO75449
Human Protein Atlas [tissue]ENSG00000186625-KATNA1 [tissue]
Peptide AtlasO75449
HPRD05986
IPIIPI00013075   IPI00384339   IPI00642229   IPI00645787   
Protein Interaction databases
DIP (DOE-UCLA)O75449
IntAct (EBI)O75449
FunCoupENSG00000186625
BioGRIDKATNA1
STRING (EMBL)KATNA1
ZODIACKATNA1
Ontologies - Pathways
QuickGOO75449
Ontology : AmiGOspindle pole  protein binding  ATP binding  nucleus  cytoplasm  microtubule organizing center  spindle  microtubule  cell cycle  microtubule binding  microtubule-severing ATPase activity  microtubule-severing ATPase activity  ATPase activity  midbody  cytoplasmic microtubule organization  protein heterodimerization activity  microtubule severing  cell division  mitotic spindle pole  
Ontology : EGO-EBIspindle pole  protein binding  ATP binding  nucleus  cytoplasm  microtubule organizing center  spindle  microtubule  cell cycle  microtubule binding  microtubule-severing ATPase activity  microtubule-severing ATPase activity  ATPase activity  midbody  cytoplasmic microtubule organization  protein heterodimerization activity  microtubule severing  cell division  mitotic spindle pole  
NDEx NetworkKATNA1
Atlas of Cancer Signalling NetworkKATNA1
Wikipedia pathwaysKATNA1
Orthology - Evolution
OrthoDB11104
GeneTree (enSembl)ENSG00000186625
Phylogenetic Trees/Animal Genes : TreeFamKATNA1
HOVERGENO75449
HOGENOMO75449
Homologs : HomoloGeneKATNA1
Homology/Alignments : Family Browser (UCSC)KATNA1
Gene fusions - Rearrangements
Fusion : MitelmanKATNA1/LATS1 [6q25.1/6q25.1]  
Fusion : MitelmanKATNA1/PPP2R1A [6q25.1/19q13.41]  [t(6;19)(q25;q13)]  
Fusion PortalKATNA1 6q25.1 LATS1 6q25.1 BRCA
Fusion PortalKATNA1 6q25.1 PPP2R1A 19q13.41 BRCA
Fusion : QuiverKATNA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKATNA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KATNA1
dbVarKATNA1
ClinVarKATNA1
1000_GenomesKATNA1 
Exome Variant ServerKATNA1
ExAC (Exome Aggregation Consortium)ENSG00000186625
GNOMAD BrowserENSG00000186625
Varsome BrowserKATNA1
Genetic variants : HAPMAP11104
Genomic Variants (DGV)KATNA1 [DGVbeta]
DECIPHERKATNA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKATNA1 
Mutations
ICGC Data PortalKATNA1 
TCGA Data PortalKATNA1 
Broad Tumor PortalKATNA1
OASIS PortalKATNA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKATNA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKATNA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KATNA1
DgiDB (Drug Gene Interaction Database)KATNA1
DoCM (Curated mutations)KATNA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KATNA1 (select a term)
intoGenKATNA1
Cancer3DKATNA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606696   
Orphanet
DisGeNETKATNA1
MedgenKATNA1
Genetic Testing Registry KATNA1
NextProtO75449 [Medical]
TSGene11104
GENETestsKATNA1
Target ValidationKATNA1
Huge Navigator KATNA1 [HugePedia]
snp3D : Map Gene to Disease11104
BioCentury BCIQKATNA1
ClinGenKATNA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11104
Chemical/Pharm GKB GenePA30017
Clinical trialKATNA1
Miscellaneous
canSAR (ICR)KATNA1 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKATNA1
EVEXKATNA1
GoPubMedKATNA1
iHOPKATNA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:30:05 CEST 2018

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