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Description | 381 amino acids; 41.945 kDa protein. KCMF1 protein contains ring finger (Zinc finger, ZZ-type) 3-50 (48), zinc finger (C2H2-type) 78-101 (23), nuclear localization signal (NLS) 152-168 (17), and a coiled coil domain 225-257 (33). Isoforms: Two isoforms that predicted to encode proteins containing the zinc finger domain have been identified; other isoforms are relatively shorter and not well defined. Isoform bApr07: This partial mRNA is 625 bp long. It is reconstructed from a myeloma cDNA clone. The pre-messenger RNA has 5 exons and covers 74.08 kb. The predicted partial protein has 208 aa (22.9 kDa, pI 5.8) and a very good coding score (7). It contains one Zinc finger, ZZ-type domain, one zinc finger, C2H2-type domain. Isoform dApr07: The dApr07 mRNA variant is 431 bp long. It is reconstructed from a testis cDNA clone. The pre-mRNA has 4 exons and covers 12.72 kb. The predicted partial protein has 143 aa (15.7 kDa, pI 7.2) and a very good coding score (5). It contains one zinc finger, C2H2-type domain. |
Expression | Ubiquitously expressed. High level of expression is in pharynx, thyroid, respiratory tract and larynx; less expressed in female system, uterus and cervix. |
Localisation | Nuclear. |
Function | KCMF1 is a transcription factor. Basic functions of the KCMF1 gene are (i) early gene up-regulation during growth factor-induced branching tubulogenesis, (ii) ubiquitination through intrinsic E3 ubiquitin ligase activity, and (iii) a possible role in ion channel activity. |
Homology | The percent identity below represents identity of KCMF1 over an aligned region in UniGene. Pan troglodytes: 97 (Percentage Identity) Canis lupas familiaris: 91 Bos Taurus: 90 Mus musculus: 96 Gallus gallus: 93 Danio rerio: 85. |
FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. |
Jang JH. |
FEBS Lett. 2004 Dec 3;578(1-2):21-5. |
PMID 15581609 |
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Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells. |
Kreppel M, Aryee DN, Schaefer KL, Amann G, Kofler R, Poremba C, Kovar H. |
Oncogene. 2006 May 4;25(19):2795-800. |
PMID 16314831 |
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Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis. |
Li Z, Stuart RO, Eraly SA, Gittes G, Beier DR, Nigam SK. |
Biochem Biophys Res Commun. 2003 Jul 4;306(3):623-8. |
PMID 12810064 |
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