Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNA2 (potassium voltage-gated channel subfamily A member 2)

Identity

Alias_namespotassium voltage-gated channel
Alias_symbol (synonym)Kv1.2
HK4
Other aliasEIEE32
HBK5
HUKIV
KV1.2
MK2
NGK1
RBK2
HGNC (Hugo) KCNA2
LocusID (NCBI) 3737
Atlas_Id 50252
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 110593580 and ends at 110631474 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNA2   6220
Cards
Entrez_Gene (NCBI)KCNA2  3737  potassium voltage-gated channel subfamily A member 2
AliasesEIEE32; HBK5; HK4; HUKIV; 
KV1.2; MK2; NGK1; RBK2
GeneCards (Weizmann)KCNA2
Ensembl hg19 (Hinxton)ENSG00000177301 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177301 [Gene_View]  chr1:110593580-110631474 [Contig_View]  KCNA2 [Vega]
ICGC DataPortalENSG00000177301
TCGA cBioPortalKCNA2
AceView (NCBI)KCNA2
Genatlas (Paris)KCNA2
WikiGenes3737
SOURCE (Princeton)KCNA2
Genetics Home Reference (NIH)KCNA2
Genomic and cartography
GoldenPath hg38 (UCSC)KCNA2  -     chr1:110593580-110631474 -  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNA2  -     1p13.3   [Description]    (hg19-Feb_2009)
EnsemblKCNA2 - 1p13.3 [CytoView hg19]  KCNA2 - 1p13.3 [CytoView hg38]
Mapping of homologs : NCBIKCNA2 [Mapview hg19]  KCNA2 [Mapview hg38]
OMIM176262   616366   
Gene and transcription
Genbank (Entrez)AK290061 BC043564 BI907383 BM682747 L02752
RefSeq transcript (Entrez)NM_001204269 NM_004974
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNA2
Cluster EST : UnigeneHs.731191 [ NCBI ]
CGAP (NCI)Hs.731191
Alternative Splicing GalleryENSG00000177301
Gene ExpressionKCNA2 [ NCBI-GEO ]   KCNA2 [ EBI - ARRAY_EXPRESS ]   KCNA2 [ SEEK ]   KCNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3737
GTEX Portal (Tissue expression)KCNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16389   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16389  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16389
Splice isoforms : SwissVarP16389
PhosPhoSitePlusP16389
Domains : Interpro (EBI)BTB/POZ_dom    Channel_four-helix_dom    Ion_trans_dom    K_chnl_volt-dep_Kv    K_chnl_volt-dep_Kv1    K_chnl_volt-dep_Kv1.2    SKP1/BTB/POZ    T1-type_BTB    VG_K_chnl   
Domain families : Pfam (Sanger)BTB_2 (PF02214)    Ion_trans (PF00520)   
Domain families : Pfam (NCBI)pfam02214    pfam00520   
Domain families : Smart (EMBL)BTB (SM00225)  
Conserved Domain (NCBI)KCNA2
DMDM Disease mutations3737
Blocks (Seattle)KCNA2
SuperfamilyP16389
Human Protein AtlasENSG00000177301
Peptide AtlasP16389
HPRD01443
IPIIPI00028134   IPI00844248   
Protein Interaction databases
DIP (DOE-UCLA)P16389
IntAct (EBI)P16389
FunCoupENSG00000177301
BioGRIDKCNA2
STRING (EMBL)KCNA2
ZODIACKCNA2
Ontologies - Pathways
QuickGOP16389
Ontology : AmiGOvoltage-gated potassium channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  potassium channel activity  protein binding  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  potassium ion transport  voltage-gated potassium channel complex  regulation of dopamine secretion  outward rectifier potassium channel activity  neuronal action potential  sensory perception of pain  kinesin binding  optic nerve structural organization  lamellipodium  cell junction  axon  dendrite  lamellipodium membrane  neuronal cell body membrane  regulation of ion transmembrane transport  presynaptic membrane  perikaryon  axon terminus  juxtaparanode region of axon  regulation of circadian sleep/wake cycle, non-REM sleep  protein homooligomerization  potassium ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated potassium channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  potassium channel activity  protein binding  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  potassium ion transport  voltage-gated potassium channel complex  regulation of dopamine secretion  outward rectifier potassium channel activity  neuronal action potential  sensory perception of pain  kinesin binding  optic nerve structural organization  lamellipodium  cell junction  axon  dendrite  lamellipodium membrane  neuronal cell body membrane  regulation of ion transmembrane transport  presynaptic membrane  perikaryon  axon terminus  juxtaparanode region of axon  regulation of circadian sleep/wake cycle, non-REM sleep  protein homooligomerization  potassium ion transmembrane transport  potassium ion transmembrane transport  
Pathways : BIOCARTARoles of ?-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    ?-arrestins in GPCR Desensitization [Genes]    Role of ?-arrestins in the activation and targeting of MAP kinases [Genes]   
NDEx NetworkKCNA2
Atlas of Cancer Signalling NetworkKCNA2
Wikipedia pathwaysKCNA2
Orthology - Evolution
OrthoDB3737
GeneTree (enSembl)ENSG00000177301
Phylogenetic Trees/Animal Genes : TreeFamKCNA2
HOVERGENP16389
HOGENOMP16389
Homologs : HomoloGeneKCNA2
Homology/Alignments : Family Browser (UCSC)KCNA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNA2
dbVarKCNA2
ClinVarKCNA2
1000_GenomesKCNA2 
Exome Variant ServerKCNA2
ExAC (Exome Aggregation Consortium)KCNA2 (select the gene name)
Genetic variants : HAPMAP3737
Genomic Variants (DGV)KCNA2 [DGVbeta]
DECIPHERKCNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNA2 
Mutations
ICGC Data PortalKCNA2 
TCGA Data PortalKCNA2 
Broad Tumor PortalKCNA2
OASIS PortalKCNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNA2
DgiDB (Drug Gene Interaction Database)KCNA2
DoCM (Curated mutations)KCNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNA2 (select a term)
intoGenKCNA2
Cancer3DKCNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176262    616366   
Orphanet23427    23427   
MedgenKCNA2
Genetic Testing Registry KCNA2
NextProtP16389 [Medical]
TSGene3737
GENETestsKCNA2
Target ValidationKCNA2
Huge Navigator KCNA2 [HugePedia]
snp3D : Map Gene to Disease3737
BioCentury BCIQKCNA2
ClinGenKCNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3737
Chemical/Pharm GKB GenePA206
Clinical trialKCNA2
Miscellaneous
canSAR (ICR)KCNA2 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNA2
EVEXKCNA2
GoPubMedKCNA2
iHOPKCNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:14:01 CEST 2017

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