Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNA3 (potassium voltage-gated channel subfamily A member 3)

Identity

Alias_namespotassium voltage-gated channel, shaker-related subfamily, member 3
potassium channel
Alias_symbol (synonym)Kv1.3
MK3
HLK3
HPCN3
Other aliasHGK5
HUKIII
KV1.3
PCN3
HGNC (Hugo) KCNA3
LocusID (NCBI) 3738
Atlas_Id 43811
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 110672452 and ends at 110675033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNA3   6221
Cards
Entrez_Gene (NCBI)KCNA3  3738  potassium voltage-gated channel subfamily A member 3
AliasesHGK5; HLK3; HPCN3; HUKIII; 
KV1.3; MK3; PCN3
GeneCards (Weizmann)KCNA3
Ensembl hg19 (Hinxton)ENSG00000177272 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177272 [Gene_View]  ENSG00000177272 [Sequence]  chr1:110672452-110675033 [Contig_View]  KCNA3 [Vega]
ICGC DataPortalENSG00000177272
TCGA cBioPortalKCNA3
AceView (NCBI)KCNA3
Genatlas (Paris)KCNA3
WikiGenes3738
SOURCE (Princeton)KCNA3
Genetics Home Reference (NIH)KCNA3
Genomic and cartography
GoldenPath hg38 (UCSC)KCNA3  -     chr1:110672452-110675033 -  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNA3  -     1p13.3   [Description]    (hg19-Feb_2009)
EnsemblKCNA3 - 1p13.3 [CytoView hg19]  KCNA3 - 1p13.3 [CytoView hg38]
Mapping of homologs : NCBIKCNA3 [Mapview hg19]  KCNA3 [Mapview hg38]
OMIM176263   
Gene and transcription
Genbank (Entrez)AA811374 AK314009 BC035059 BC064595 BM995500
RefSeq transcript (Entrez)NM_002232
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNA3
Cluster EST : UnigeneHs.628223 [ NCBI ]
CGAP (NCI)Hs.628223
Alternative Splicing GalleryENSG00000177272
Gene ExpressionKCNA3 [ NCBI-GEO ]   KCNA3 [ EBI - ARRAY_EXPRESS ]   KCNA3 [ SEEK ]   KCNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3738
GTEX Portal (Tissue expression)KCNA3
Human Protein AtlasENSG00000177272-KCNA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22001   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22001  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22001
Splice isoforms : SwissVarP22001
PhosPhoSitePlusP22001
Domains : Interpro (EBI)BTB/POZ_dom    Ion_trans_dom    K_chnl_volt-dep_Kv    K_chnl_volt-dep_Kv1    K_chnl_volt-dep_Kv1.3    SKP1/BTB/POZ_sf    T1-type_BTB    VG_K_chnl    Volt_channel_dom_sf   
Domain families : Pfam (Sanger)BTB_2 (PF02214)    Ion_trans (PF00520)   
Domain families : Pfam (NCBI)pfam02214    pfam00520   
Domain families : Smart (EMBL)BTB (SM00225)  
Conserved Domain (NCBI)KCNA3
DMDM Disease mutations3738
Blocks (Seattle)KCNA3
PDB (SRS)4BGC   
PDB (PDBSum)4BGC   
PDB (IMB)4BGC   
PDB (RSDB)4BGC   
Structural Biology KnowledgeBase4BGC   
SCOP (Structural Classification of Proteins)4BGC   
CATH (Classification of proteins structures)4BGC   
SuperfamilyP22001
Human Protein Atlas [tissue]ENSG00000177272-KCNA3 [tissue]
Peptide AtlasP22001
HPRD15937
IPIIPI00217447   
Protein Interaction databases
DIP (DOE-UCLA)P22001
IntAct (EBI)P22001
FunCoupENSG00000177272
BioGRIDKCNA3
STRING (EMBL)KCNA3
ZODIACKCNA3
Ontologies - Pathways
QuickGOP22001
Ontology : AmiGOvoltage-gated ion channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  protein binding  plasma membrane  potassium ion transport  voltage-gated potassium channel complex  outward rectifier potassium channel activity  integral component of membrane  axon  regulation of ion transmembrane transport  calyx of Held  membrane raft  protein homooligomerization  potassium ion transmembrane transport  potassium ion export across plasma membrane  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  
Ontology : EGO-EBIvoltage-gated ion channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  protein binding  plasma membrane  potassium ion transport  voltage-gated potassium channel complex  outward rectifier potassium channel activity  integral component of membrane  axon  regulation of ion transmembrane transport  calyx of Held  membrane raft  protein homooligomerization  potassium ion transmembrane transport  potassium ion export across plasma membrane  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  
NDEx NetworkKCNA3
Atlas of Cancer Signalling NetworkKCNA3
Wikipedia pathwaysKCNA3
Orthology - Evolution
OrthoDB3738
GeneTree (enSembl)ENSG00000177272
Phylogenetic Trees/Animal Genes : TreeFamKCNA3
HOVERGENP22001
HOGENOMP22001
Homologs : HomoloGeneKCNA3
Homology/Alignments : Family Browser (UCSC)KCNA3
Gene fusions - Rearrangements
Fusion : QuiverKCNA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNA3
dbVarKCNA3
ClinVarKCNA3
1000_GenomesKCNA3 
Exome Variant ServerKCNA3
ExAC (Exome Aggregation Consortium)ENSG00000177272
GNOMAD BrowserENSG00000177272
Varsome BrowserKCNA3
Genetic variants : HAPMAP3738
Genomic Variants (DGV)KCNA3 [DGVbeta]
DECIPHERKCNA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNA3 
Mutations
ICGC Data PortalKCNA3 
TCGA Data PortalKCNA3 
Broad Tumor PortalKCNA3
OASIS PortalKCNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNA3
DgiDB (Drug Gene Interaction Database)KCNA3
DoCM (Curated mutations)KCNA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNA3 (select a term)
intoGenKCNA3
Cancer3DKCNA3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176263   
Orphanet
DisGeNETKCNA3
MedgenKCNA3
Genetic Testing Registry KCNA3
NextProtP22001 [Medical]
TSGene3738
GENETestsKCNA3
Target ValidationKCNA3
Huge Navigator KCNA3 [HugePedia]
snp3D : Map Gene to Disease3738
BioCentury BCIQKCNA3
ClinGenKCNA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3738
Chemical/Pharm GKB GenePA30021
Clinical trialKCNA3
Miscellaneous
canSAR (ICR)KCNA3 (select the gene name)
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNA3
EVEXKCNA3
GoPubMedKCNA3
iHOPKCNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:14:24 CET 2018

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