Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNA4 (potassium voltage-gated channel subfamily A member 4)

Identity

Alias_namesKCNA4L
potassium voltage-gated channel, shaker-related subfamily, member 4-like
potassium voltage-gated channel, shaker-related subfamily, member 4
Alias_symbol (synonym)Kv1.4
HK1
HPCN2
Other aliasHBK4
HUKII
KCNA8
KV1.4
PCN2
HGNC (Hugo) KCNA4
LocusID (NCBI) 3739
Atlas_Id 52634
Location 11p14.1  [Link to chromosome band 11p14]
Location_base_pair Starts at 30031288 and ends at 30038577 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNA4   6222
Cards
Entrez_Gene (NCBI)KCNA4  3739  potassium voltage-gated channel subfamily A member 4
AliasesHBK4; HK1; HPCN2; HUKII; 
KCNA4L; KCNA8; KV1.4; PCN2
GeneCards (Weizmann)KCNA4
Ensembl hg19 (Hinxton)ENSG00000182255 [Gene_View]  chr11:30031288-30038577 [Contig_View]  KCNA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182255 [Gene_View]  chr11:30031288-30038577 [Contig_View]  KCNA4 [Vega]
ICGC DataPortalENSG00000182255
TCGA cBioPortalKCNA4
AceView (NCBI)KCNA4
Genatlas (Paris)KCNA4
WikiGenes3739
SOURCE (Princeton)KCNA4
Genetics Home Reference (NIH)KCNA4
Genomic and cartography
GoldenPath hg19 (UCSC)KCNA4  -     chr11:30031288-30038577 -  11p14.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KCNA4  -     11p14.1   [Description]    (hg38-Dec_2013)
EnsemblKCNA4 - 11p14.1 [CytoView hg19]  KCNA4 - 11p14.1 [CytoView hg38]
Mapping of homologs : NCBIKCNA4 [Mapview hg19]  KCNA4 [Mapview hg38]
OMIM176266   
Gene and transcription
Genbank (Entrez)AK311228 AK313662 BC166685 BE467209 DA328650
RefSeq transcript (Entrez)NM_002233
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_042309 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)KCNA4
Cluster EST : UnigeneHs.592002 [ NCBI ]
CGAP (NCI)Hs.592002
Alternative Splicing GalleryENSG00000182255
Gene ExpressionKCNA4 [ NCBI-GEO ]   KCNA4 [ EBI - ARRAY_EXPRESS ]   KCNA4 [ SEEK ]   KCNA4 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3739
GTEX Portal (Tissue expression)KCNA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22459   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22459  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22459
Splice isoforms : SwissVarP22459
PhosPhoSitePlusP22459
Domains : Interpro (EBI)BTB/POZ_dom    Channel_four-helix_dom    Ion_trans_dom    K_chnl_volt-dep_Kv    K_chnl_volt-dep_Kv1    K_chnl_volt-dep_Kv1.4    K_chnl_volt-dep_Kv1.4_TID    SKP1/BTB/POZ    T1-type_BTB    VG_K_chnl   
Domain families : Pfam (Sanger)BTB_2 (PF02214)    Ion_trans (PF00520)    K_channel_TID (PF07941)   
Domain families : Pfam (NCBI)pfam02214    pfam00520    pfam07941   
Domain families : Smart (EMBL)BTB (SM00225)  
Conserved Domain (NCBI)KCNA4
DMDM Disease mutations3739
Blocks (Seattle)KCNA4
SuperfamilyP22459
Human Protein AtlasENSG00000182255
Peptide AtlasP22459
HPRD01444
IPIIPI00304582   
Protein Interaction databases
DIP (DOE-UCLA)P22459
IntAct (EBI)P22459
FunCoupENSG00000182255
BioGRIDKCNA4
STRING (EMBL)KCNA4
ZODIACKCNA4
Ontologies - Pathways
QuickGOP22459
Ontology : AmiGOvoltage-gated potassium channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  protein binding  plasma membrane  integral component of plasma membrane  potassium ion transport  voltage-gated potassium channel complex  voltage-gated potassium channel complex  integral component of membrane  axon  potassium ion binding  regulation of ion transmembrane transport  protein homooligomerization  potassium ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated potassium channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  protein binding  plasma membrane  integral component of plasma membrane  potassium ion transport  voltage-gated potassium channel complex  voltage-gated potassium channel complex  integral component of membrane  axon  potassium ion binding  regulation of ion transmembrane transport  protein homooligomerization  potassium ion transmembrane transport  potassium ion transmembrane transport  
NDEx NetworkKCNA4
Atlas of Cancer Signalling NetworkKCNA4
Wikipedia pathwaysKCNA4
Orthology - Evolution
OrthoDB3739
GeneTree (enSembl)ENSG00000182255
Phylogenetic Trees/Animal Genes : TreeFamKCNA4
HOVERGENP22459
HOGENOMP22459
Homologs : HomoloGeneKCNA4
Homology/Alignments : Family Browser (UCSC)KCNA4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNA4
dbVarKCNA4
ClinVarKCNA4
1000_GenomesKCNA4 
Exome Variant ServerKCNA4
ExAC (Exome Aggregation Consortium)KCNA4 (select the gene name)
Genetic variants : HAPMAP3739
Genomic Variants (DGV)KCNA4 [DGVbeta]
DECIPHER (Syndromes)11:30031288-30038577  ENSG00000182255
CONAN: Copy Number AnalysisKCNA4 
Mutations
ICGC Data PortalKCNA4 
TCGA Data PortalKCNA4 
Broad Tumor PortalKCNA4
OASIS PortalKCNA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNA4
DgiDB (Drug Gene Interaction Database)KCNA4
DoCM (Curated mutations)KCNA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNA4 (select a term)
intoGenKCNA4
Cancer3DKCNA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176266   
Orphanet
MedgenKCNA4
Genetic Testing Registry KCNA4
NextProtP22459 [Medical]
TSGene3739
GENETestsKCNA4
Huge Navigator KCNA4 [HugePedia]
snp3D : Map Gene to Disease3739
BioCentury BCIQKCNA4
ClinGenKCNA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3739
Chemical/Pharm GKB GenePA207
Clinical trialKCNA4
Miscellaneous
canSAR (ICR)KCNA4 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNA4
EVEXKCNA4
GoPubMedKCNA4
iHOPKCNA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:48 CEST 2017

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