Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNB1 (potassium voltage-gated channel subfamily B member 1)

Identity

Alias_namespotassium voltage-gated channel
Alias_symbol (synonym)Kv2.1
Other aliasDRK1
HGNC (Hugo) KCNB1
LocusID (NCBI) 3745
Atlas_Id 56087
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 47980414 and ends at 48099181 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNB1   6231
Cards
Entrez_Gene (NCBI)KCNB1  3745  potassium voltage-gated channel subfamily B member 1
AliasesDRK1; Kv2.1
GeneCards (Weizmann)KCNB1
Ensembl hg19 (Hinxton)ENSG00000158445 [Gene_View]  chr20:47980414-48099181 [Contig_View]  KCNB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000158445 [Gene_View]  chr20:47980414-48099181 [Contig_View]  KCNB1 [Vega]
ICGC DataPortalENSG00000158445
TCGA cBioPortalKCNB1
AceView (NCBI)KCNB1
Genatlas (Paris)KCNB1
WikiGenes3745
SOURCE (Princeton)KCNB1
Genetics Home Reference (NIH)KCNB1
Genomic and cartography
GoldenPath hg19 (UCSC)KCNB1  -     chr20:47980414-48099181 -  20q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KCNB1  -     20q13.13   [Description]    (hg38-Dec_2013)
EnsemblKCNB1 - 20q13.13 [CytoView hg19]  KCNB1 - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBIKCNB1 [Mapview hg19]  KCNB1 [Mapview hg38]
OMIM600397   616056   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_004975
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNB1
Cluster EST : UnigeneHs.633143 [ NCBI ]
CGAP (NCI)Hs.633143
Alternative Splicing GalleryENSG00000158445
Gene ExpressionKCNB1 [ NCBI-GEO ]   KCNB1 [ EBI - ARRAY_EXPRESS ]   KCNB1 [ SEEK ]   KCNB1 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3745
GTEX Portal (Tissue expression)KCNB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14721   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14721  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14721
Splice isoforms : SwissVarQ14721
PhosPhoSitePlusQ14721
Domains : Interpro (EBI)BTB/POZ_dom    Channel_four-helix_dom    Ion_trans_dom    K_chnl_volt-dep_Kv    K_chnl_volt-dep_Kv2    K_chnl_volt-dep_Kv2.1    SKP1/BTB/POZ    T1-type_BTB    VG_K_chnl   
Domain families : Pfam (Sanger)BTB_2 (PF02214)    Ion_trans (PF00520)    Kv2channel (PF03521)   
Domain families : Pfam (NCBI)pfam02214    pfam00520    pfam03521   
Domain families : Smart (EMBL)BTB (SM00225)  
Conserved Domain (NCBI)KCNB1
DMDM Disease mutations3745
Blocks (Seattle)KCNB1
SuperfamilyQ14721
Human Protein AtlasENSG00000158445
Peptide AtlasQ14721
HPRD08983
IPIIPI00033019   IPI01011705   
Protein Interaction databases
DIP (DOE-UCLA)Q14721
IntAct (EBI)Q14721
FunCoupENSG00000158445
BioGRIDKCNB1
STRING (EMBL)KCNB1
ZODIACKCNB1
Ontologies - Pathways
QuickGOQ14721
Ontology : AmiGOaction potential  delayed rectifier potassium channel activity  delayed rectifier potassium channel activity  protein binding  intracellular  plasma membrane  plasma membrane  vesicle docking involved in exocytosis  glutamate receptor signaling pathway  voltage-gated potassium channel complex  voltage-gated potassium channel complex  positive regulation of norepinephrine secretion  lateral plasma membrane  cell junction  axon  dendrite  cellular response to nutrient levels  ubiquitin-like protein binding  neuronal cell body membrane  positive regulation of catecholamine secretion  regulation of ion transmembrane transport  sarcolemma  glucose homeostasis  perikaryon  ion channel binding  postsynaptic membrane  positive regulation of calcium ion-dependent exocytosis  negative regulation of insulin secretion  protein heterodimerization activity  regulation of insulin secretion  protein homooligomerization  cellular response to glucose stimulus  potassium ion transmembrane transport  potassium ion transmembrane transport  protein targeting to plasma membrane  positive regulation of protein targeting to membrane  positive regulation of protein targeting to membrane  regulation of action potential  positive regulation of long term synaptic depression  regulation of motor neuron apoptotic process  
Ontology : EGO-EBIaction potential  delayed rectifier potassium channel activity  delayed rectifier potassium channel activity  protein binding  intracellular  plasma membrane  plasma membrane  vesicle docking involved in exocytosis  glutamate receptor signaling pathway  voltage-gated potassium channel complex  voltage-gated potassium channel complex  positive regulation of norepinephrine secretion  lateral plasma membrane  cell junction  axon  dendrite  cellular response to nutrient levels  ubiquitin-like protein binding  neuronal cell body membrane  positive regulation of catecholamine secretion  regulation of ion transmembrane transport  sarcolemma  glucose homeostasis  perikaryon  ion channel binding  postsynaptic membrane  positive regulation of calcium ion-dependent exocytosis  negative regulation of insulin secretion  protein heterodimerization activity  regulation of insulin secretion  protein homooligomerization  cellular response to glucose stimulus  potassium ion transmembrane transport  potassium ion transmembrane transport  protein targeting to plasma membrane  positive regulation of protein targeting to membrane  positive regulation of protein targeting to membrane  regulation of action potential  positive regulation of long term synaptic depression  regulation of motor neuron apoptotic process  
Pathways : KEGGTaste transduction   
NDEx NetworkKCNB1
Atlas of Cancer Signalling NetworkKCNB1
Wikipedia pathwaysKCNB1
Orthology - Evolution
OrthoDB3745
GeneTree (enSembl)ENSG00000158445
Phylogenetic Trees/Animal Genes : TreeFamKCNB1
HOVERGENQ14721
HOGENOMQ14721
Homologs : HomoloGeneKCNB1
Homology/Alignments : Family Browser (UCSC)KCNB1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNB1
dbVarKCNB1
ClinVarKCNB1
1000_GenomesKCNB1 
Exome Variant ServerKCNB1
ExAC (Exome Aggregation Consortium)KCNB1 (select the gene name)
Genetic variants : HAPMAP3745
Genomic Variants (DGV)KCNB1 [DGVbeta]
DECIPHER (Syndromes)20:47980414-48099181  ENSG00000158445
CONAN: Copy Number AnalysisKCNB1 
Mutations
ICGC Data PortalKCNB1 
TCGA Data PortalKCNB1 
Broad Tumor PortalKCNB1
OASIS PortalKCNB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNB1
DgiDB (Drug Gene Interaction Database)KCNB1
DoCM (Curated mutations)KCNB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNB1 (select a term)
intoGenKCNB1
Cancer3DKCNB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600397    616056   
Orphanet23427   
MedgenKCNB1
Genetic Testing Registry KCNB1
NextProtQ14721 [Medical]
TSGene3745
GENETestsKCNB1
Huge Navigator KCNB1 [HugePedia]
snp3D : Map Gene to Disease3745
BioCentury BCIQKCNB1
ClinGenKCNB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3745
Chemical/Pharm GKB GenePA209
Clinical trialKCNB1
Miscellaneous
canSAR (ICR)KCNB1 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNB1
EVEXKCNB1
GoPubMedKCNB1
iHOPKCNB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:11:28 CET 2017

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