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KCNB2 (potassium voltage-gated channel subfamily B member 2)

Identity

Alias_namespotassium voltage-gated channel, Shab-related subfamily, member 2
Alias_symbol (synonym)Kv2.2
Other aliasKV2.2
HGNC (Hugo) KCNB2
LocusID (NCBI) 9312
Atlas_Id 64765
Location 8q21.11  [Link to chromosome band 8q21]
Location_base_pair Starts at 72537391 and ends at 72938349 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LRP12 (8q22.3) / KCNB2 (8q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNB2   6232
Cards
Entrez_Gene (NCBI)KCNB2  9312  potassium voltage-gated channel subfamily B member 2
AliasesKV2.2
GeneCards (Weizmann)KCNB2
Ensembl hg19 (Hinxton)ENSG00000182674 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182674 [Gene_View]  chr8:72537391-72938349 [Contig_View]  KCNB2 [Vega]
ICGC DataPortalENSG00000182674
TCGA cBioPortalKCNB2
AceView (NCBI)KCNB2
Genatlas (Paris)KCNB2
WikiGenes9312
SOURCE (Princeton)KCNB2
Genetics Home Reference (NIH)KCNB2
Genomic and cartography
GoldenPath hg38 (UCSC)KCNB2  -     chr8:72537391-72938349 +  8q21.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNB2  -     8q21.11   [Description]    (hg19-Feb_2009)
EnsemblKCNB2 - 8q21.11 [CytoView hg19]  KCNB2 - 8q21.11 [CytoView hg38]
Mapping of homologs : NCBIKCNB2 [Mapview hg19]  KCNB2 [Mapview hg38]
OMIM607738   
Gene and transcription
Genbank (Entrez)AF338730 AF450111 AK311263 BC140387 U69962
RefSeq transcript (Entrez)NM_004770
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNB2
Cluster EST : UnigeneHs.661102 [ NCBI ]
CGAP (NCI)Hs.661102
Alternative Splicing GalleryENSG00000182674
Gene ExpressionKCNB2 [ NCBI-GEO ]   KCNB2 [ EBI - ARRAY_EXPRESS ]   KCNB2 [ SEEK ]   KCNB2 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9312
GTEX Portal (Tissue expression)KCNB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92953   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92953  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92953
Splice isoforms : SwissVarQ92953
PhosPhoSitePlusQ92953
Domains : Interpro (EBI)BTB/POZ_dom    Ion_trans_dom    K_chnl_volt-dep_Kv    K_chnl_volt-dep_Kv2    K_chnl_volt-dep_Kv2.2    SKP1/BTB/POZ    T1-type_BTB    VG_K_chnl   
Domain families : Pfam (Sanger)BTB_2 (PF02214)    Ion_trans (PF00520)    Kv2channel (PF03521)   
Domain families : Pfam (NCBI)pfam02214    pfam00520    pfam03521   
Domain families : Smart (EMBL)BTB (SM00225)  
Conserved Domain (NCBI)KCNB2
DMDM Disease mutations9312
Blocks (Seattle)KCNB2
SuperfamilyQ92953
Human Protein AtlasENSG00000182674
Peptide AtlasQ92953
HPRD09666
IPIIPI00024330   
Protein Interaction databases
DIP (DOE-UCLA)Q92953
IntAct (EBI)Q92953
FunCoupENSG00000182674
BioGRIDKCNB2
STRING (EMBL)KCNB2
ZODIACKCNB2
Ontologies - Pathways
QuickGOQ92953
Ontology : AmiGOvoltage-gated potassium channel activity  delayed rectifier potassium channel activity  intracellular  plasma membrane  plasma membrane  potassium ion transport  regulation of smooth muscle contraction  voltage-gated potassium channel complex  integral component of membrane  dendrite  neuronal cell body membrane  regulation of ion transmembrane transport  perikaryon  protein heterodimerization activity  protein homooligomerization  potassium ion transmembrane transport  potassium ion transmembrane transport  protein targeting to plasma membrane  
Ontology : EGO-EBIvoltage-gated potassium channel activity  delayed rectifier potassium channel activity  intracellular  plasma membrane  plasma membrane  potassium ion transport  regulation of smooth muscle contraction  voltage-gated potassium channel complex  integral component of membrane  dendrite  neuronal cell body membrane  regulation of ion transmembrane transport  perikaryon  protein heterodimerization activity  protein homooligomerization  potassium ion transmembrane transport  potassium ion transmembrane transport  protein targeting to plasma membrane  
NDEx NetworkKCNB2
Atlas of Cancer Signalling NetworkKCNB2
Wikipedia pathwaysKCNB2
Orthology - Evolution
OrthoDB9312
GeneTree (enSembl)ENSG00000182674
Phylogenetic Trees/Animal Genes : TreeFamKCNB2
HOVERGENQ92953
HOGENOMQ92953
Homologs : HomoloGeneKCNB2
Homology/Alignments : Family Browser (UCSC)KCNB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNB2
dbVarKCNB2
ClinVarKCNB2
1000_GenomesKCNB2 
Exome Variant ServerKCNB2
ExAC (Exome Aggregation Consortium)KCNB2 (select the gene name)
Genetic variants : HAPMAP9312
Genomic Variants (DGV)KCNB2 [DGVbeta]
DECIPHERKCNB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNB2 
Mutations
ICGC Data PortalKCNB2 
TCGA Data PortalKCNB2 
Broad Tumor PortalKCNB2
OASIS PortalKCNB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNB2
DgiDB (Drug Gene Interaction Database)KCNB2
DoCM (Curated mutations)KCNB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNB2 (select a term)
intoGenKCNB2
Cancer3DKCNB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607738   
Orphanet
MedgenKCNB2
Genetic Testing Registry KCNB2
NextProtQ92953 [Medical]
TSGene9312
GENETestsKCNB2
Huge Navigator KCNB2 [HugePedia]
snp3D : Map Gene to Disease9312
BioCentury BCIQKCNB2
ClinGenKCNB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9312
Chemical/Pharm GKB GenePA30025
Clinical trialKCNB2
Miscellaneous
canSAR (ICR)KCNB2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNB2
EVEXKCNB2
GoPubMedKCNB2
iHOPKCNB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:17:30 CEST 2017

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