Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KCNC4 (potassium voltage-gated channel subfamily C member 4)

Identity

Alias_namesC1orf30
chromosome 1 open reading frame 30
potassium voltage-gated channel, Shaw-related subfamily, member 4
potassium channel, voltage gated Shaw related subfamily C, member 4
Alias_symbol (synonym)Kv3.4
HKSHIIIC
Other aliasKSHIIIC
KV3.4
HGNC (Hugo) KCNC4
LocusID (NCBI) 3749
Atlas_Id 57047
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 110210714 and ends at 110234052 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KCNC4 (1p13.3) / GSTM4 (1p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  KCNC4/GSTM4 (1p13)

External links

Nomenclature
HGNC (Hugo)KCNC4   6236
Cards
Entrez_Gene (NCBI)KCNC4  3749  potassium voltage-gated channel subfamily C member 4
AliasesC1orf30; HKSHIIIC; KSHIIIC; KV3.4
GeneCards (Weizmann)KCNC4
Ensembl hg19 (Hinxton)ENSG00000116396 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116396 [Gene_View]  ENSG00000116396 [Sequence]  chr1:110210714-110234052 [Contig_View]  KCNC4 [Vega]
ICGC DataPortalENSG00000116396
TCGA cBioPortalKCNC4
AceView (NCBI)KCNC4
Genatlas (Paris)KCNC4
WikiGenes3749
SOURCE (Princeton)KCNC4
Genetics Home Reference (NIH)KCNC4
Genomic and cartography
GoldenPath hg38 (UCSC)KCNC4  -     chr1:110210714-110234052 +  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNC4  -     1p13.3   [Description]    (hg19-Feb_2009)
GoldenPathKCNC4 - 1p13.3 [CytoView hg19]  KCNC4 - 1p13.3 [CytoView hg38]
ImmunoBaseENSG00000116396
Mapping of homologs : NCBIKCNC4 [Mapview hg19]  KCNC4 [Mapview hg38]
OMIM176265   
Gene and transcription
Genbank (Entrez)AI369490 AK125567 AK310193 BC025377 BC101769
RefSeq transcript (Entrez)NM_001039574 NM_004978 NM_153763
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNC4
Cluster EST : UnigeneHs.153521 [ NCBI ]
CGAP (NCI)Hs.153521
Alternative Splicing GalleryENSG00000116396
Gene ExpressionKCNC4 [ NCBI-GEO ]   KCNC4 [ EBI - ARRAY_EXPRESS ]   KCNC4 [ SEEK ]   KCNC4 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3749
GTEX Portal (Tissue expression)KCNC4
Human Protein AtlasENSG00000116396-KCNC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03721   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03721  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03721
Splice isoforms : SwissVarQ03721
PhosPhoSitePlusQ03721
Domains : Interpro (EBI)BTB/POZ_dom    Ion_trans_dom    K_chnl_volt-dep_Kv    K_chnl_volt-dep_Kv3    K_chnl_volt-dep_Kv3.4    K_chnl_volt-dep_Kv3_ID    SKP1/BTB/POZ_sf    T1-type_BTB    VG_K_chnl    Volt_channel_dom_sf   
Domain families : Pfam (Sanger)BTB_2 (PF02214)    Ion_trans (PF00520)    Potassium_chann (PF11404)   
Domain families : Pfam (NCBI)pfam02214    pfam00520    pfam11404   
Domain families : Smart (EMBL)BTB (SM00225)  
Conserved Domain (NCBI)KCNC4
DMDM Disease mutations3749
Blocks (Seattle)KCNC4
PDB (RSDB)1B4G    1B4I    1ZTN   
PDB Europe1B4G    1B4I    1ZTN   
PDB (PDBSum)1B4G    1B4I    1ZTN   
PDB (IMB)1B4G    1B4I    1ZTN   
Structural Biology KnowledgeBase1B4G    1B4I    1ZTN   
SCOP (Structural Classification of Proteins)1B4G    1B4I    1ZTN   
CATH (Classification of proteins structures)1B4G    1B4I    1ZTN   
SuperfamilyQ03721
Human Protein Atlas [tissue]ENSG00000116396-KCNC4 [tissue]
Peptide AtlasQ03721
IPIIPI00306756   IPI00604682   IPI00736536   
Protein Interaction databases
DIP (DOE-UCLA)Q03721
IntAct (EBI)Q03721
FunCoupENSG00000116396
BioGRIDKCNC4
STRING (EMBL)KCNC4
ZODIACKCNC4
Ontologies - Pathways
QuickGOQ03721
Ontology : AmiGOvoltage-gated potassium channel activity  delayed rectifier potassium channel activity  potassium channel activity  protein binding  plasma membrane  potassium ion transport  chemical synaptic transmission  voltage-gated potassium channel complex  integral component of membrane  axon  neuromuscular junction  dendrite membrane  neuronal cell body membrane  regulation of ion transmembrane transport  neuronal cell body  axon terminus  regulation of neurotransmitter secretion  protein homooligomerization  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated potassium channel activity  delayed rectifier potassium channel activity  potassium channel activity  protein binding  plasma membrane  potassium ion transport  chemical synaptic transmission  voltage-gated potassium channel complex  integral component of membrane  axon  neuromuscular junction  dendrite membrane  neuronal cell body membrane  regulation of ion transmembrane transport  neuronal cell body  axon terminus  regulation of neurotransmitter secretion  protein homooligomerization  potassium ion transmembrane transport  
NDEx NetworkKCNC4
Atlas of Cancer Signalling NetworkKCNC4
Wikipedia pathwaysKCNC4
Orthology - Evolution
OrthoDB3749
GeneTree (enSembl)ENSG00000116396
Phylogenetic Trees/Animal Genes : TreeFamKCNC4
HOGENOMQ03721
Homologs : HomoloGeneKCNC4
Homology/Alignments : Family Browser (UCSC)KCNC4
Gene fusions - Rearrangements
Fusion : QuiverKCNC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNC4
dbVarKCNC4
ClinVarKCNC4
1000_GenomesKCNC4 
Exome Variant ServerKCNC4
ExAC (Exome Aggregation Consortium)ENSG00000116396
GNOMAD BrowserENSG00000116396
Varsome BrowserKCNC4
Genetic variants : HAPMAP3749
Genomic Variants (DGV)KCNC4 [DGVbeta]
DECIPHERKCNC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNC4 
Mutations
ICGC Data PortalKCNC4 
TCGA Data PortalKCNC4 
Broad Tumor PortalKCNC4
OASIS PortalKCNC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNC4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKCNC4
Mutations and Diseases : HGMDKCNC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNC4
DgiDB (Drug Gene Interaction Database)KCNC4
DoCM (Curated mutations)KCNC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNC4 (select a term)
intoGenKCNC4
Cancer3DKCNC4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176265   
Orphanet
DisGeNETKCNC4
MedgenKCNC4
Genetic Testing Registry KCNC4
NextProtQ03721 [Medical]
TSGene3749
GENETestsKCNC4
Target ValidationKCNC4
Huge Navigator KCNC4 [HugePedia]
snp3D : Map Gene to Disease3749
BioCentury BCIQKCNC4
ClinGenKCNC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3749
Chemical/Pharm GKB GenePA30028
Clinical trialKCNC4
Miscellaneous
canSAR (ICR)KCNC4 (select the gene name)
DataMed IndexKCNC4
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNC4
EVEXKCNC4
GoPubMedKCNC4
iHOPKCNC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:49:11 CET 2019
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