KCNC4 (potassium voltage-gated channel subfamily C member 4)

2017-08-01 Affiliation

Identity

HGNC

KCNC4

LOCATION

1p13.3

LOCUSID

3749

ALIAS

C1orf30,HKSHIIIC,KSHIIIC,KV3.4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3749
MIM: 176265
HGNC: 6236
Ensembl: ENSG00000116396

Variants:

dbSNP: 3749
ClinVar: 3749
TCGA: ENSG00000116396
COSMIC: KCNC4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116396	ENST00000369787	Q03721
ENSG00000116396	ENST00000413138	H7BZ66
ENSG00000116396	ENST00000438661	Q03721
ENSG00000116396	ENST00000469655	Q03721
ENSG00000116396	ENST00000636402	A0A1B0GVB7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Potassium Channels	REACTOME	R-HSA-1296071
Voltage gated Potassium channels	REACTOME	R-HSA-1296072

References

Pubmed ID	Year	Title	Citations
15485486	2004	Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.	30
25609640	2015	Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury.	21
16449802	2006	Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis.	16
23443853	2013	Kv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cells.	13
21912965	2012	Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.	12
22473424	2012	Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.	6
20093253	2010	Cell cycle-dependent expression of Kv3.4 channels modulates proliferation of human uterine artery smooth muscle cells.	4
26648458	2016	Expression of the voltage-gated potassium channel Kv3.4 in oral leucoplakias and oral squamous cell carcinomas.	2
31471334	2019	HIF-1α Regulates Proliferation and Invasion of Oral Cancer Cells through Kv3.4 Channel.	0

Citation

Dessen P

KCNC4 (potassium voltage-gated channel subfamily C member 4)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57047/kcnc4