Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNE2 (potassium voltage-gated channel, Isk-related family, member 2)

Identity

Other namesATFB4
LQT5
LQT6
MIRP1
HGNC (Hugo) KCNE2
LocusID (NCBI) 9992
Location 21q22.11
Location_base_pair Starts at 35736323 and ends at 35743440 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)KCNE2   6242
Cards
Entrez_Gene (NCBI)KCNE2  9992  potassium voltage-gated channel, Isk-related family, member 2
GeneCards (Weizmann)KCNE2
Ensembl (Hinxton) [Gene_View]  chr21:35736323-35743440 [Contig_View]  KCNE2 [Vega]
cBioPortalKCNE2
AceView (NCBI)KCNE2
Genatlas (Paris)KCNE2
WikiGenes9992
SOURCE (Princeton)NM_172201
Genomic and cartography
GoldenPath (UCSC)KCNE2  -  21q22.11   chr21:35736323-35743440 +  21q22.11   [Description]    (hg19-Feb_2009)
EnsemblKCNE2 - 21q22.11 [CytoView]
Mapping of homologs : NCBIKCNE2 [Mapview]
OMIM603796   611493   613693   
Gene and transcription
Genbank (Entrez)AF071002 AF086086 AF302095 BC093892 BC112087
RefSeq transcript (Entrez)NM_172201
RefSeq genomic (Entrez)AC_000153 NC_000021 NC_018932 NG_008804 NT_011512 NW_001838706 NW_004929426
Consensus coding sequences : CCDS (NCBI)KCNE2
Cluster EST : UnigeneHs.736062 [ NCBI ]
CGAP (NCI)Hs.736062
Alternative Splicing : Fast-db (Paris)GSHG0019443
Gene ExpressionKCNE2 [ NCBI-GEO ]     KCNE2 [ SEEK ]   KCNE2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6J6 (Uniprot)
NextProtQ9Y6J6  [Medical]
With graphics : InterProQ9Y6J6
Splice isoforms : SwissVarQ9Y6J6 (Swissvar)
Domains : Interpro (EBI)K_chnl_volt-dep_bsu_KCNE [organisation]   K_chnl_volt-dep_bsu_KCNE1 [organisation]   K_chnl_volt-dep_bsu_KCNE2 [organisation]  
Related proteins : CluSTrQ9Y6J6
Domain families : Pfam (Sanger)ISK_Channel (PF02060)   
Domain families : Pfam (NCBI)pfam02060   
DMDM Disease mutations9992
Blocks (Seattle)Q9Y6J6
Peptide AtlasQ9Y6J6
HPRD04813
IPIIPI00002366   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6J6
IntAct (EBI)Q9Y6J6
BioGRIDKCNE2
InParanoidQ9Y6J6
Interologous Interaction database Q9Y6J6
IntegromeDBKCNE2
STRING (EMBL)KCNE2
Ontologies - Pathways
Ontology : AmiGOinward rectifier potassium channel activity  delayed rectifier potassium channel activity  lysosome  plasma membrane  aging  voltage-gated potassium channel complex  cell surface  potassium ion import  potassium channel regulator activity  cellular protein localization  cellular response to drug  protein homodimerization activity  tongue development  ion channel binding  regulation of membrane repolarization  regulation of ventricular cardiac muscle cell membrane repolarization  potassium ion export  potassium ion transmembrane transport  cardiac muscle cell action potential involved in contraction  ventricular cardiac muscle cell action potential  membrane repolarization  membrane repolarization during action potential  regulation of heart rate by cardiac conduction  regulation of potassium ion transmembrane transport  positive regulation of proteasomal protein catabolic process  regulation of inward rectifier potassium channel activity  regulation of cyclic nucleotide-gated ion channel activity  regulation of delayed rectifier potassium channel activity  voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  
Ontology : EGO-EBIinward rectifier potassium channel activity  delayed rectifier potassium channel activity  lysosome  plasma membrane  aging  voltage-gated potassium channel complex  cell surface  potassium ion import  potassium channel regulator activity  cellular protein localization  cellular response to drug  protein homodimerization activity  tongue development  ion channel binding  regulation of membrane repolarization  regulation of ventricular cardiac muscle cell membrane repolarization  potassium ion export  potassium ion transmembrane transport  cardiac muscle cell action potential involved in contraction  ventricular cardiac muscle cell action potential  membrane repolarization  membrane repolarization during action potential  regulation of heart rate by cardiac conduction  regulation of potassium ion transmembrane transport  positive regulation of proteasomal protein catabolic process  regulation of inward rectifier potassium channel activity  regulation of cyclic nucleotide-gated ion channel activity  regulation of delayed rectifier potassium channel activity  voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  
Pathways : KEGGGastric acid secretion   
Protein Interaction DatabaseKCNE2
Wikipedia pathwaysKCNE2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)KCNE2
snp3D : Map Gene to Disease9992
SNP (GeneSNP Utah)KCNE2
SNP : HGBaseKCNE2
Genetic variants : HAPMAPKCNE2
Exome VariantKCNE2
1000_GenomesKCNE2 
Somatic Mutations in Cancer : COSMICKCNE2 
CONAN: Copy Number AnalysisKCNE2 
Mutations and Diseases : HGMDKCNE2
Mutations and Diseases : intOGenKCNE2
Genomic VariantsKCNE2  KCNE2 [DGVbeta]
dbVarKCNE2
ClinVarKCNE2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603796    611493    613693   
MedgenKCNE2
GENETestsKCNE2
Disease Genetic AssociationKCNE2
Huge Navigator KCNE2 [HugePedia]  KCNE2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneKCNE2
Homology/Alignments : Family Browser (UCSC)KCNE2
Phylogenetic Trees/Animal Genes : TreeFamKCNE2
Chemical/Protein Interactions : CTD9992
Chemical/Pharm GKB GenePA392
Clinical trialKCNE2
Other databases
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
CoreMineKCNE2
iHOPKCNE2
OncoSearchKCNE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:51:33 CEST 2014

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