Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)

Identity

Alias_namespotassium voltage-gated channel, Isk-related family, member 3
potassium channel, voltage gated subfamily E regulatory beta subunit 3
Alias_symbol (synonym)MiRP2
HOKPP
Other aliasHYPP
HGNC (Hugo) KCNE3
LocusID (NCBI) 10008
Atlas_Id 64774
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 74454841 and ends at 74467555 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCNE3 (11q13.4) / PSME1 (14q12)UVRAG (11q13.5) / KCNE3 (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNE3   6243
LRG (Locus Reference Genomic)LRG_439
Cards
Entrez_Gene (NCBI)KCNE3  10008  potassium voltage-gated channel subfamily E regulatory subunit 3
AliasesHOKPP; HYPP; MiRP2
GeneCards (Weizmann)KCNE3
Ensembl hg19 (Hinxton)ENSG00000175538 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175538 [Gene_View]  chr11:74454841-74467555 [Contig_View]  KCNE3 [Vega]
ICGC DataPortalENSG00000175538
TCGA cBioPortalKCNE3
AceView (NCBI)KCNE3
Genatlas (Paris)KCNE3
WikiGenes10008
SOURCE (Princeton)KCNE3
Genetics Home Reference (NIH)KCNE3
Genomic and cartography
GoldenPath hg38 (UCSC)KCNE3  -     chr11:74454841-74467555 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNE3  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblKCNE3 - 11q13.4 [CytoView hg19]  KCNE3 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIKCNE3 [Mapview hg19]  KCNE3 [Mapview hg38]
OMIM604433   613119   
Gene and transcription
Genbank (Entrez)AF076531 AF302494 AK311876 BC032235 BC110612
RefSeq transcript (Entrez)NM_005472
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNE3
Cluster EST : UnigeneHs.523899 [ NCBI ]
CGAP (NCI)Hs.523899
Alternative Splicing GalleryENSG00000175538
Gene ExpressionKCNE3 [ NCBI-GEO ]   KCNE3 [ EBI - ARRAY_EXPRESS ]   KCNE3 [ SEEK ]   KCNE3 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNE3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10008
GTEX Portal (Tissue expression)KCNE3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6H6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6H6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6H6
Splice isoforms : SwissVarQ9Y6H6
PhosPhoSitePlusQ9Y6H6
Domains : Interpro (EBI)K_chnl_KCNE    K_chnl_volt-dep_bsu_KCNE3   
Domain families : Pfam (Sanger)ISK_Channel (PF02060)   
Domain families : Pfam (NCBI)pfam02060   
Conserved Domain (NCBI)KCNE3
DMDM Disease mutations10008
Blocks (Seattle)KCNE3
PDB (SRS)2NDJ   
PDB (PDBSum)2NDJ   
PDB (IMB)2NDJ   
PDB (RSDB)2NDJ   
Structural Biology KnowledgeBase2NDJ   
SCOP (Structural Classification of Proteins)2NDJ   
CATH (Classification of proteins structures)2NDJ   
SuperfamilyQ9Y6H6
Human Protein AtlasENSG00000175538
Peptide AtlasQ9Y6H6
HPRD07256
IPIIPI00002294   IPI00984967   IPI00976626   IPI00976047   IPI00977799   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6H6
IntAct (EBI)Q9Y6H6
FunCoupENSG00000175538
BioGRIDKCNE3
STRING (EMBL)KCNE3
ZODIACKCNE3
Ontologies - Pathways
QuickGOQ9Y6H6
Ontology : AmiGOvoltage-gated potassium channel activity  protein binding  cytoplasm  plasma membrane  voltage-gated potassium channel complex  potassium channel regulator activity  dendrite  vesicle  neuronal cell body membrane  perikaryon  ion channel binding  membrane raft  potassium ion transmembrane transport  regulation of heart rate by cardiac conduction  positive regulation of voltage-gated calcium channel activity  negative regulation of delayed rectifier potassium channel activity  negative regulation of potassium ion export across plasma membrane  negative regulation of voltage-gated potassium channel activity  negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential  
Ontology : EGO-EBIvoltage-gated potassium channel activity  protein binding  cytoplasm  plasma membrane  voltage-gated potassium channel complex  potassium channel regulator activity  dendrite  vesicle  neuronal cell body membrane  perikaryon  ion channel binding  membrane raft  potassium ion transmembrane transport  regulation of heart rate by cardiac conduction  positive regulation of voltage-gated calcium channel activity  negative regulation of delayed rectifier potassium channel activity  negative regulation of potassium ion export across plasma membrane  negative regulation of voltage-gated potassium channel activity  negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential  
Pathways : KEGGProtein digestion and absorption   
NDEx NetworkKCNE3
Atlas of Cancer Signalling NetworkKCNE3
Wikipedia pathwaysKCNE3
Orthology - Evolution
OrthoDB10008
GeneTree (enSembl)ENSG00000175538
Phylogenetic Trees/Animal Genes : TreeFamKCNE3
HOVERGENQ9Y6H6
HOGENOMQ9Y6H6
Homologs : HomoloGeneKCNE3
Homology/Alignments : Family Browser (UCSC)KCNE3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNE3
dbVarKCNE3
ClinVarKCNE3
1000_GenomesKCNE3 
Exome Variant ServerKCNE3
ExAC (Exome Aggregation Consortium)KCNE3 (select the gene name)
Genetic variants : HAPMAP10008
Genomic Variants (DGV)KCNE3 [DGVbeta]
DECIPHERKCNE3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNE3 
Mutations
ICGC Data PortalKCNE3 
TCGA Data PortalKCNE3 
Broad Tumor PortalKCNE3
OASIS PortalKCNE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNE3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNE3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNE3
DgiDB (Drug Gene Interaction Database)KCNE3
DoCM (Curated mutations)KCNE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNE3 (select a term)
intoGenKCNE3
Cancer3DKCNE3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604433    613119   
Orphanet211    8022   
MedgenKCNE3
Genetic Testing Registry KCNE3
NextProtQ9Y6H6 [Medical]
TSGene10008
GENETestsKCNE3
Target ValidationKCNE3
Huge Navigator KCNE3 [HugePedia]
snp3D : Map Gene to Disease10008
BioCentury BCIQKCNE3
ClinGenKCNE3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10008
Chemical/Pharm GKB GenePA393
Clinical trialKCNE3
Miscellaneous
canSAR (ICR)KCNE3 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNE3
EVEXKCNE3
GoPubMedKCNE3
iHOPKCNE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:11:35 CEST 2017

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