Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4)

Identity

Alias_namespotassium voltage-gated channel, Isk-related family, member 4
potassium channel, voltage gated subfamily E regulatory beta subunit 4
Alias_symbol (synonym)MiRP3
Other aliasMIRP3
HGNC (Hugo) KCNE4
LocusID (NCBI) 23704
Atlas_Id 64775
Location 2q36.1  [Link to chromosome band 2q36]
Location_base_pair Starts at 223051930 and ends at 223055637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNE4   6244
Cards
Entrez_Gene (NCBI)KCNE4  23704  potassium voltage-gated channel subfamily E regulatory subunit 4
AliasesMIRP3
GeneCards (Weizmann)KCNE4
Ensembl hg19 (Hinxton)ENSG00000152049 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152049 [Gene_View]  ENSG00000152049 [Sequence]  chr2:223051930-223055637 [Contig_View]  KCNE4 [Vega]
ICGC DataPortalENSG00000152049
TCGA cBioPortalKCNE4
AceView (NCBI)KCNE4
Genatlas (Paris)KCNE4
WikiGenes23704
SOURCE (Princeton)KCNE4
Genetics Home Reference (NIH)KCNE4
Genomic and cartography
GoldenPath hg38 (UCSC)KCNE4  -     chr2:223051930-223055637 +  2q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNE4  -     2q36.1   [Description]    (hg19-Feb_2009)
GoldenPathKCNE4 - 2q36.1 [CytoView hg19]  KCNE4 - 2q36.1 [CytoView hg38]
ImmunoBaseENSG00000152049
Mapping of homologs : NCBIKCNE4 [Mapview hg19]  KCNE4 [Mapview hg38]
OMIM607775   
Gene and transcription
Genbank (Entrez)AK294423 AK313203 AY065987 BC014429 BM662449
RefSeq transcript (Entrez)NM_080671
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNE4
Cluster EST : UnigeneHs.348522 [ NCBI ]
CGAP (NCI)Hs.348522
Alternative Splicing GalleryENSG00000152049
Gene ExpressionKCNE4 [ NCBI-GEO ]   KCNE4 [ EBI - ARRAY_EXPRESS ]   KCNE4 [ SEEK ]   KCNE4 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNE4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23704
GTEX Portal (Tissue expression)KCNE4
Human Protein AtlasENSG00000152049-KCNE4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WWG9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WWG9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WWG9
Splice isoforms : SwissVarQ8WWG9
PhosPhoSitePlusQ8WWG9
Domains : Interpro (EBI)K_chnl_KCNE   
Domain families : Pfam (Sanger)ISK_Channel (PF02060)   
Domain families : Pfam (NCBI)pfam02060   
Conserved Domain (NCBI)KCNE4
DMDM Disease mutations23704
Blocks (Seattle)KCNE4
SuperfamilyQ8WWG9
Human Protein Atlas [tissue]ENSG00000152049-KCNE4 [tissue]
Peptide AtlasQ8WWG9
HPRD09689
IPIIPI00103336   
Protein Interaction databases
DIP (DOE-UCLA)Q8WWG9
IntAct (EBI)Q8WWG9
FunCoupENSG00000152049
BioGRIDKCNE4
STRING (EMBL)KCNE4
ZODIACKCNE4
Ontologies - Pathways
QuickGOQ8WWG9
Ontology : AmiGOdelayed rectifier potassium channel activity  protein binding  voltage-gated potassium channel complex  potassium channel regulator activity  apical plasma membrane  ion channel binding  ion channel binding  regulation of ventricular cardiac muscle cell membrane repolarization  ventricular cardiac muscle cell action potential  membrane repolarization during action potential  regulation of heart rate by cardiac conduction  potassium ion export across plasma membrane  membrane repolarization during ventricular cardiac muscle cell action potential  negative regulation of delayed rectifier potassium channel activity  voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  
Ontology : EGO-EBIdelayed rectifier potassium channel activity  protein binding  voltage-gated potassium channel complex  potassium channel regulator activity  apical plasma membrane  ion channel binding  ion channel binding  regulation of ventricular cardiac muscle cell membrane repolarization  ventricular cardiac muscle cell action potential  membrane repolarization during action potential  regulation of heart rate by cardiac conduction  potassium ion export across plasma membrane  membrane repolarization during ventricular cardiac muscle cell action potential  negative regulation of delayed rectifier potassium channel activity  voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization  
NDEx NetworkKCNE4
Atlas of Cancer Signalling NetworkKCNE4
Wikipedia pathwaysKCNE4
Orthology - Evolution
OrthoDB23704
GeneTree (enSembl)ENSG00000152049
Phylogenetic Trees/Animal Genes : TreeFamKCNE4
HOGENOMQ8WWG9
Homologs : HomoloGeneKCNE4
Homology/Alignments : Family Browser (UCSC)KCNE4
Gene fusions - Rearrangements
Fusion : QuiverKCNE4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNE4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNE4
dbVarKCNE4
ClinVarKCNE4
1000_GenomesKCNE4 
Exome Variant ServerKCNE4
ExAC (Exome Aggregation Consortium)ENSG00000152049
GNOMAD BrowserENSG00000152049
Varsome BrowserKCNE4
Genetic variants : HAPMAP23704
Genomic Variants (DGV)KCNE4 [DGVbeta]
DECIPHERKCNE4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNE4 
Mutations
ICGC Data PortalKCNE4 
TCGA Data PortalKCNE4 
Broad Tumor PortalKCNE4
OASIS PortalKCNE4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNE4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKCNE4
Mutations and Diseases : HGMDKCNE4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNE4
DgiDB (Drug Gene Interaction Database)KCNE4
DoCM (Curated mutations)KCNE4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNE4 (select a term)
intoGenKCNE4
Cancer3DKCNE4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607775   
Orphanet
DisGeNETKCNE4
MedgenKCNE4
Genetic Testing Registry KCNE4
NextProtQ8WWG9 [Medical]
TSGene23704
GENETestsKCNE4
Target ValidationKCNE4
Huge Navigator KCNE4 [HugePedia]
snp3D : Map Gene to Disease23704
BioCentury BCIQKCNE4
ClinGenKCNE4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23704
Chemical/Pharm GKB GenePA30032
Clinical trialKCNE4
Miscellaneous
canSAR (ICR)KCNE4 (select the gene name)
DataMed IndexKCNE4
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNE4
EVEXKCNE4
GoPubMedKCNE4
iHOPKCNE4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 15:32:31 CEST 2019

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