KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4)

2014-11-01  

Identity

HGNC
KCNE4
LOCATION
2q36.1
LOCUSID
23704
ALIAS
MIRP3

Other Information

Locus ID:

NCBI: 23704
MIM: 607775
HGNC: 6244
Ensembl: ENSG00000152049

Variants:

dbSNP: 23704
ClinVar: 23704
TCGA: ENSG00000152049
COSMIC: KCNE4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152049ENST00000281830Q8WWG9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 2 - plateau phaseREACTOMER-HSA-5576893
Phase 3 - rapid repolarisationREACTOMER-HSA-5576890

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182793882008KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex.26
129442702003KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.24
197733572009KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating.22
170160492007The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population.19
170160492007The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population.19
157079972005hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.15
211188092011KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.15
204982292010The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.13
184633152008MiRP3 acts as an accessory subunit with the BK potassium channel.12
165632432005[The association of single nucleotide polymorphism of slow delayed rectifier K+ channel genes with atrial fibrillation in Han nationality Chinese].11

Citation

Dessen P

KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64775/kcne4