KCNG4 (potassium voltage-gated channel modifier subfamily G member 4)

2014-11-01 Affiliation

Identity

HGNC

KCNG4

LOCATION

16q24.1

LOCUSID

93107

ALIAS

KV6.3,KV6.4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 93107
MIM: 607603
HGNC: 19697
Ensembl: ENSG00000168418

Variants:

dbSNP: 93107
ClinVar: 93107
TCGA: ENSG00000168418
COSMIC: KCNG4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168418	ENST00000308251	Q8TDN1
ENSG00000168418	ENST00000308251	Q547S7
ENSG00000168418	ENST00000568181	Q8TDN1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Potassium Channels	REACTOME	R-HSA-1296071
Voltage gated Potassium channels	REACTOME	R-HSA-1296072

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
12060745	2002	Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.	51
16096342	2005	Domain analysis of Kv6.3, an electrically silent channel.	14
26242757	2015	Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.	10
19074135	2009	Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.	7
26505474	2015	Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.	6

Citation

Dessen P

KCNG4 (potassium voltage-gated channel modifier subfamily G member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64779/kcng4