Identity
HGNC
LOCATION
4p15.31
LOCUSID
ALIAS
CALP,KCHIP4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 80333
MIM: 608182
HGNC: 30083
Ensembl: ENSG00000185774
Variants:
dbSNP: 80333
ClinVar: 80333
TCGA: ENSG00000185774
COSMIC: KCNIP4
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Muscle contraction | REACTOME | R-HSA-397014 |
| Cardiac conduction | REACTOME | R-HSA-5576891 |
| Phase 1 - inactivation of fast Na+ channels | REACTOME | R-HSA-5576894 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712308 | Ace Inhibitors, Plain | Chemical | ClinicalAnnotation | associated | PD | 26169577, 28084903 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 26169577 | 2016 | A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. | 32 |
| 26169577 | 2016 | A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. | 32 |
| 24811166 | 2014 | The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level. | 18 |
| 24811166 | 2014 | The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level. | 18 |
| 22981920 | 2013 | KCNIP4 as a candidate gene for personality disorders and adult ADHD. | 16 |
| 23457522 | 2013 | Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. | 17 |
| 23576435 | 2013 | Auxiliary KChIP4a suppresses A-type K+ current through endoplasmic reticulum (ER) retention and promoting closed-state inactivation of Kv4 channels. | 11 |
| 22981920 | 2013 | KCNIP4 as a candidate gene for personality disorders and adult ADHD. | 16 |
| 23457522 | 2013 | Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. | 17 |
| 23576435 | 2013 | Auxiliary KChIP4a suppresses A-type K+ current through endoplasmic reticulum (ER) retention and promoting closed-state inactivation of Kv4 channels. | 11 |
| 20877300 | 2012 | Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. | 42 |
| 20877300 | 2012 | Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. | 42 |
| 21624954 | 2011 | RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration. | 21 |
| 21624954 | 2011 | RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration. | 21 |
| 19910543 | 2010 | Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. | 7 |
Citation
Dessen P
KCNIP4 (potassium voltage-gated channel interacting protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/49981/kcnip4
