Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11)

Identity

Other namesBIR
HHF2
IKATP
KIR6.2
PHHI
TNDM3
HGNC (Hugo) KCNJ11
LocusID (NCBI) 3767
Location 11p15.1
Location_base_pair Starts at 17406796 and ends at 17410206 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)KCNJ11   6257
Cards
Entrez_Gene (NCBI)KCNJ11  3767  potassium inwardly-rectifying channel, subfamily J, member 11
GeneCards (Weizmann)KCNJ11
Ensembl (Hinxton)ENSG00000187486 [Gene_View]  chr11:17406796-17410206 [Contig_View]  KCNJ11 [Vega]
ICGC DataPortalENSG00000187486
cBioPortalKCNJ11
AceView (NCBI)KCNJ11
Genatlas (Paris)KCNJ11
WikiGenes3767
SOURCE (Princeton)NM_000525 NM_001166290
Genomic and cartography
GoldenPath (UCSC)KCNJ11  -  11p15.1   chr11:17406796-17410206 -  11p15.1   [Description]    (hg19-Feb_2009)
EnsemblKCNJ11 - 11p15.1 [CytoView]
Mapping of homologs : NCBIKCNJ11 [Mapview]
OMIM125853   600937   601820   606176   610582   
Gene and transcription
Genbank (Entrez)AI377272 AK301550 AK314943 BC040617 BC064497
RefSeq transcript (Entrez)NM_000525 NM_001166290
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_012446 NT_009237 NW_001838022 NW_004929378
Consensus coding sequences : CCDS (NCBI)KCNJ11
Cluster EST : UnigeneHs.248141 [ NCBI ]
CGAP (NCI)Hs.248141
Alternative Splicing GalleryENSG00000187486
Gene ExpressionKCNJ11 [ NCBI-GEO ]     KCNJ11 [ SEEK ]   KCNJ11 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14654 (Uniprot)
NextProtQ14654  [Medical]
With graphics : InterProQ14654
Splice isoforms : SwissVarQ14654 (Swissvar)
Domains : Interpro (EBI)Ig_E-set [organisation]   K_chnl_inward-rec_Kir [organisation]   K_chnl_inward-rec_Kir6.2 [organisation]   K_chnl_inward-rec_Kir_cyto [organisation]  
Related proteins : CluSTrQ14654
Domain families : Pfam (Sanger)IRK (PF01007)   
Domain families : Pfam (NCBI)pfam01007   
DMDM Disease mutations3767
Blocks (Seattle)Q14654
Human Protein AtlasENSG00000187486 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ14654
HPRD09022
IPIIPI00291902   IPI00953564   IPI00980434   IPI00978316   
Protein Interaction databases
DIP (DOE-UCLA)Q14654
IntAct (EBI)Q14654
FunCoupENSG00000187486
BioGRIDKCNJ11
InParanoidQ14654
Interologous Interaction database Q14654
IntegromeDBKCNJ11
STRING (EMBL)KCNJ11
Ontologies - Pathways
Ontology : AmiGOresponse to ischemia  voltage-gated potassium channel activity  ATP binding  nuclear envelope  mitochondrion  endosome  endoplasmic reticulum  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  glucose metabolic process  energy reserve metabolic process  synaptic transmission  protein C-terminus binding  voltage-gated potassium channel complex  ATP-sensitive potassium channel complex  ATP-sensitive potassium channel complex  potassium ion import  intercalated disc  ATP-activated inward rectifier potassium channel activity  T-tubule  ankyrin binding  axolemma  potassium ion binding  heat shock protein binding  response to estradiol  response to ATP  response to testosterone  regulation of membrane potential  response to drug  neuronal cell body  myelin sheath  small molecule metabolic process  ion channel binding  negative regulation of insulin secretion  regulation of insulin secretion  regulation of insulin secretion  neurological system process  cell body fiber  cellular response to nicotine  cellular response to glucose stimulus  cellular response to tumor necrosis factor  potassium ion transmembrane transport  positive regulation of cation channel activity  
Ontology : EGO-EBIresponse to ischemia  voltage-gated potassium channel activity  ATP binding  nuclear envelope  mitochondrion  endosome  endoplasmic reticulum  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  glucose metabolic process  energy reserve metabolic process  synaptic transmission  protein C-terminus binding  voltage-gated potassium channel complex  ATP-sensitive potassium channel complex  ATP-sensitive potassium channel complex  potassium ion import  intercalated disc  ATP-activated inward rectifier potassium channel activity  T-tubule  ankyrin binding  axolemma  potassium ion binding  heat shock protein binding  response to estradiol  response to ATP  response to testosterone  regulation of membrane potential  response to drug  neuronal cell body  myelin sheath  small molecule metabolic process  ion channel binding  negative regulation of insulin secretion  regulation of insulin secretion  regulation of insulin secretion  neurological system process  cell body fiber  cellular response to nicotine  cellular response to glucose stimulus  cellular response to tumor necrosis factor  potassium ion transmembrane transport  positive regulation of cation channel activity  
Pathways : KEGGInsulin secretion    Type II diabetes mellitus   
Protein Interaction DatabaseKCNJ11
Wikipedia pathwaysKCNJ11
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)KCNJ11
snp3D : Map Gene to Disease3767
SNP (GeneSNP Utah)KCNJ11
SNP : HGBaseKCNJ11
Genetic variants : HAPMAPKCNJ11
Exome VariantKCNJ11
1000_GenomesKCNJ11 
ICGC programENSG00000187486 
Somatic Mutations in Cancer : COSMICKCNJ11 
CONAN: Copy Number AnalysisKCNJ11 
Mutations and Diseases : HGMDKCNJ11
Mutations and Diseases : intOGenKCNJ11
Genomic VariantsKCNJ11  KCNJ11 [DGVbeta]
dbVarKCNJ11
ClinVarKCNJ11
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM125853    600937    601820    606176    610582   
MedgenKCNJ11
GENETestsKCNJ11
Disease Genetic AssociationKCNJ11
Huge Navigator KCNJ11 [HugePedia]  KCNJ11 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneKCNJ11
Homology/Alignments : Family Browser (UCSC)KCNJ11
Phylogenetic Trees/Animal Genes : TreeFamKCNJ11
Chemical/Protein Interactions : CTD3767
Chemical/Pharm GKB GenePA217
Clinical trialKCNJ11
Cancer Resource (Charite)ENSG00000187486
Other databases
Probes
Litterature
PubMed299 Pubmed reference(s) in Entrez
CoreMineKCNJ11
iHOPKCNJ11
OncoSearchKCNJ11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:51:35 CEST 2014

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