KCNJ15 (potassium inwardly rectifying channel subfamily J member 15)

2014-11-01 Affiliation

Identity

HGNC

KCNJ15

LOCATION

21q22.13

LOCUSID

3772

ALIAS

IRKK,KIR1.3,KIR4.2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3772
MIM: 602106
HGNC: 6261
Ensembl: ENSG00000157551

Variants:

dbSNP: 3772
ClinVar: 3772
TCGA: ENSG00000157551
COSMIC: KCNJ15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157551	ENST00000328656	Q99712
ENSG00000157551	ENST00000398925	A8MTZ5
ENSG00000157551	ENST00000398927	A8MVK1
ENSG00000157551	ENST00000398928	A8MVK1
ENSG00000157551	ENST00000398930	Q99712
ENSG00000157551	ENST00000398932	Q99712
ENSG00000157551	ENST00000398934	Q99712
ENSG00000157551	ENST00000398938	Q99712
ENSG00000157551	ENST00000417042	C9J0W5
ENSG00000157551	ENST00000419868	E7EWV2
ENSG00000157551	ENST00000438657	E7EPG3
ENSG00000157551	ENST00000443341	C9JTX1
ENSG00000157551	ENST00000547341	F8VX74
ENSG00000157551	ENST00000547595	F8VX74
ENSG00000157551	ENST00000548700	F8VX74
ENSG00000157551	ENST00000549158	F8VW46
ENSG00000157551	ENST00000549805	F8VX74
ENSG00000157551	ENST00000549932	F8VX74
ENSG00000157551	ENST00000551422	F8VX74
ENSG00000157551	ENST00000612702	Q99712
ENSG00000157551	ENST00000613499	Q99712

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
GABA receptor activation	REACTOME	R-HSA-977443
GABA B receptor activation	REACTOME	R-HSA-977444
Activation of GABAB receptors	REACTOME	R-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	REACTOME	R-HSA-997272
Potassium Channels	REACTOME	R-HSA-1296071
Inwardly rectifying K+ channels	REACTOME	R-HSA-1296065
G protein gated Potassium channels	REACTOME	R-HSA-1296059
Activation of G protein gated Potassium channels	REACTOME	R-HSA-1296041

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17122384	2007	Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function.	28
26449415	2015	KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.	22
20085713	2010	Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.	18
20085713	2010	Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.	18
22566534	2012	Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes.	11
27100087	2016	Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.	9
11804844	2002	Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel.	6
15068243	2003	Chromosome 21 KIR channels in brain development.	4
19420109	2009	MUPP1 complexes renal K+ channels to alter cell surface expression and whole cell currents.	4
26108660	2015	Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion.	4

Citation

Dessen P

KCNJ15 (potassium inwardly rectifying channel subfamily J member 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64788/kcnj15