KCNJ3 (potassium inwardly rectifying channel subfamily J member 3)

2007-02-01 Affiliation

Identity

HGNC

KCNJ3

LOCATION

2q24.1

LOCUSID

3760

ALIAS

GIRK1,KGA,KIR3.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3760
MIM: 601534
HGNC: 6264
Ensembl: ENSG00000162989

Variants:

dbSNP: 3760
ClinVar: 3760
TCGA: ENSG00000162989
COSMIC: KCNJ3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162989	ENST00000295101	P48549
ENSG00000162989	ENST00000544049	P48549
ENSG00000162989	ENST00000651198	A0A494C0M7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cholinergic synapse	KEGG	hsa04725
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
GABA receptor activation	REACTOME	R-HSA-977443
GABA B receptor activation	REACTOME	R-HSA-977444
Activation of GABAB receptors	REACTOME	R-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	REACTOME	R-HSA-997272
Potassium Channels	REACTOME	R-HSA-1296071
Inwardly rectifying K+ channels	REACTOME	R-HSA-1296065
G protein gated Potassium channels	REACTOME	R-HSA-1296059
Activation of G protein gated Potassium channels	REACTOME	R-HSA-1296041

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
15142872	2004	Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses.	18
16109170	2005	Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.	16
21927946	2012	Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population.	15
23175530	2013	Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.	15
18498071	2008	Expression of K+ channels in normal and cancerous human breast.	13
20512921	2010	Cloning and characterisation of GIRK1 variants resulting from alternative RNA editing of the KCNJ3 gene transcript in a human breast cancer cell line.	11
12458027	2002	Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes.	10
19135528	2009	Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes.	10
24392765	2014	Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery.	9

Citation

Dessen P

KCNJ3 (potassium inwardly rectifying channel subfamily J member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45811/kcnj3