Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KCNJ6 (potassium inwardly rectifying channel subfamily J member 6)

Identity

Alias (NCBI)BIR1
GIRK-2
GIRK2
KATP-2
KATP2
KCNJ7
KIR3.2
KPLBS
hiGIRK2
HGNC (Hugo) KCNJ6
HGNC Alias symbKir3.2
GIRK2
KATP2
BIR1
hiGIRK2
HGNC Previous nameKCNJ7
HGNC Previous namepotassium inwardly-rectifying channel, subfamily J, member 6
LocusID (NCBI) 3763
Atlas_Id 45915
Location 21q22.13  [Link to chromosome band 21q22]
Location_base_pair Starts at 37607373 and ends at 37916457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERG (21q22.2) / KCNJ6 (21q22.13)KCNJ6 (21q22.13) / PLCL1 (2q33.1)MLLT10 (10p12.31) / KCNJ6 (21q22.13)
SIM2 (21q22.13) / KCNJ6 (21q22.13)SLC25A51 (9p13.2) / KCNJ6 (21q22.13)ERG 21q22.2 / KCNJ6 21q22.13
MLLT10 10p12.31 / KCNJ6 21q22.13SIM2 21q22.13 / KCNJ6 21q22.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KCNJ6   6267
Cards
Entrez_Gene (NCBI)KCNJ6    potassium inwardly rectifying channel subfamily J member 6
AliasesBIR1; GIRK-2; GIRK2; KATP-2; 
KATP2; KCNJ7; KIR3.2; KPLBS; hiGIRK2
GeneCards (Weizmann)KCNJ6
Ensembl hg19 (Hinxton)ENSG00000157542 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157542 [Gene_View]  ENSG00000157542 [Sequence]  chr21:37607373-37916457 [Contig_View]  KCNJ6 [Vega]
ICGC DataPortalENSG00000157542
TCGA cBioPortalKCNJ6
AceView (NCBI)KCNJ6
Genatlas (Paris)KCNJ6
SOURCE (Princeton)KCNJ6
Genetics Home Reference (NIH)KCNJ6
Genomic and cartography
GoldenPath hg38 (UCSC)KCNJ6  -     chr21:37607373-37916457 -  21q22.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNJ6  -     21q22.13   [Description]    (hg19-Feb_2009)
GoldenPathKCNJ6 - 21q22.13 [CytoView hg19]  KCNJ6 - 21q22.13 [CytoView hg38]
ImmunoBaseENSG00000157542
genome Data Viewer NCBIKCNJ6 [Mapview hg19]  
OMIM600877   614098   
Gene and transcription
Genbank (Entrez)AJ001894 AK313997 AW015013 BC101547 BF110130
RefSeq transcript (Entrez)NM_002240
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNJ6
Alternative Splicing GalleryENSG00000157542
Gene ExpressionKCNJ6 [ NCBI-GEO ]   KCNJ6 [ EBI - ARRAY_EXPRESS ]   KCNJ6 [ SEEK ]   KCNJ6 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNJ6 [ Firebrowse - Broad ]
GenevisibleExpression of KCNJ6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3763
GTEX Portal (Tissue expression)KCNJ6
Human Protein AtlasENSG00000157542-KCNJ6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48051   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48051  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48051
Splice isoforms : SwissVarP48051
PhosPhoSitePlusP48051
Domains : Interpro (EBI)Ig_E-set    IRK_C    K_chnl_inward-rec_Kir    K_chnl_inward-rec_Kir3.2    K_chnl_inward-rec_Kir_cyto    Kir_TM   
Domain families : Pfam (Sanger)IRK (PF01007)    IRK_C (PF17655)   
Domain families : Pfam (NCBI)pfam01007    pfam17655   
Conserved Domain (NCBI)KCNJ6
Blocks (Seattle)KCNJ6
SuperfamilyP48051
Human Protein Atlas [tissue]ENSG00000157542-KCNJ6 [tissue]
Peptide AtlasP48051
HPRD02929
IPIIPI00007627   
Protein Interaction databases
DIP (DOE-UCLA)P48051
IntAct (EBI)P48051
BioGRIDKCNJ6
STRING (EMBL)KCNJ6
ZODIACKCNJ6
Ontologies - Pathways
QuickGOP48051
Ontology : AmiGOinward rectifier potassium channel activity  protein binding  Golgi apparatus  plasma membrane  plasma membrane  plasma membrane  potassium ion transport  voltage-gated potassium channel complex  G-protein activated inward rectifier potassium channel activity  regulation of ion transmembrane transport  potassium ion import across plasma membrane  
Ontology : EGO-EBIinward rectifier potassium channel activity  protein binding  Golgi apparatus  plasma membrane  plasma membrane  plasma membrane  potassium ion transport  voltage-gated potassium channel complex  G-protein activated inward rectifier potassium channel activity  regulation of ion transmembrane transport  potassium ion import across plasma membrane  
Pathways : KEGGCircadian entrainment    Retrograde endocannabinoid signaling    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Estrogen signaling pathway    Morphine addiction   
NDEx NetworkKCNJ6
Atlas of Cancer Signalling NetworkKCNJ6
Wikipedia pathwaysKCNJ6
Orthology - Evolution
OrthoDB3763
GeneTree (enSembl)ENSG00000157542
Phylogenetic Trees/Animal Genes : TreeFamKCNJ6
HOGENOMP48051
Homologs : HomoloGeneKCNJ6
Homology/Alignments : Family Browser (UCSC)KCNJ6
Gene fusions - Rearrangements
Fusion : MitelmanERG/KCNJ6 [21q22.2/21q22.13]  
Fusion : MitelmanMLLT10/KCNJ6 [10p12.31/21q22.13]  
Fusion : MitelmanSIM2/KCNJ6 [21q22.13/21q22.13]  
Fusion PortalERG 21q22.2 KCNJ6 21q22.13 PRAD
Fusion PortalMLLT10 10p12.31 KCNJ6 21q22.13 LUAD
Fusion PortalSIM2 21q22.13 KCNJ6 21q22.13 LGG
Fusion : QuiverKCNJ6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNJ6 [hg38]
dbVarKCNJ6
ClinVarKCNJ6
MonarchKCNJ6
1000_GenomesKCNJ6 
Exome Variant ServerKCNJ6
GNOMAD BrowserENSG00000157542
Varsome BrowserKCNJ6
Genomic Variants (DGV)KCNJ6 [DGVbeta]
DECIPHERKCNJ6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNJ6 
Mutations
ICGC Data PortalKCNJ6 
TCGA Data PortalKCNJ6 
Broad Tumor PortalKCNJ6
OASIS PortalKCNJ6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNJ6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKCNJ6
Mutations and Diseases : HGMDKCNJ6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNJ6
DgiDB (Drug Gene Interaction Database)KCNJ6
DoCM (Curated mutations)KCNJ6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNJ6 (select a term)
intoGenKCNJ6
Cancer3DKCNJ6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600877    614098   
Orphanet23306   
DisGeNETKCNJ6
MedgenKCNJ6
Genetic Testing Registry KCNJ6
NextProtP48051 [Medical]
GENETestsKCNJ6
Target ValidationKCNJ6
Huge Navigator KCNJ6 [HugePedia]
ClinGenKCNJ6
Clinical trials, drugs, therapy
MyCancerGenomeKCNJ6
Protein Interactions : CTD
Pharm GKB GenePA30049
PharosP48051
Clinical trialKCNJ6
Miscellaneous
canSAR (ICR)KCNJ6 (select the gene name)
HarmonizomeKCNJ6
DataMed IndexKCNJ6
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKCNJ6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:27:33 CET 2021
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.