KCNK1 (potassium two pore domain channel subfamily K member 1)

2014-11-01  

Identity

HGNC
KCNK1
LOCATION
1q42.2
LOCUSID
3775
ALIAS
DPK,HOHO,K2P1,K2p1.1,KCNO1,TWIK-1,TWIK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3775
MIM: 601745
HGNC: 6272
Ensembl: ENSG00000135750

Variants:

dbSNP: 3775
ClinVar: 3775
TCGA: ENSG00000135750
COSMIC: KCNK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135750ENST00000366621O00180
ENSG00000135750ENST00000366621A0A024R3T2
ENSG00000135750ENST00000446915Q5T5E6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Tandem pore domain potassium channelsREACTOMER-HSA-1296346
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)REACTOMER-HSA-1299308
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
222828042012Crystal structure of the human two-pore domain potassium channel K2P1.112
158206772005Sumoylation silences the plasma membrane leak K+ channel K2P1.86
195711462009TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices.71
250010862014A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.38
216532272011TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.32
199594782010Potassium channel silencing by constitutive endocytosis and intracellular sequestration.30
219644042012A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells.18
199489752009Integrative predictive model of coronary artery calcification in atherosclerosis.13
271034602016The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.4
275587212016Exploring the Dynamics of the TWIK-1 Channel.2

Citation

Dessen P

KCNK1 (potassium two pore domain channel subfamily K member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64793/kcnk1