Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK1 (potassium channel, two pore domain subfamily K, member 1)

Identity

Alias_namespotassium channel, subfamily K, member 1
potassium channel, two pore domain subfamily K, member 1
Alias_symbol (synonym)K2p1.1
DPK
TWIK-1
Other aliasHOHO
K2P1
KCNO1
TWIK1
HGNC (Hugo) KCNK1
LocusID (NCBI) 3775
Atlas_Id 64793
Location 1q42.2  [Link to chromosome band 1q42]
Location_base_pair Starts at 233749750 and ends at 233808258 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KCNK1 (1q42.2) / MKNK2 (19p13.3)U2AF2 (19q13.42) / KCNK1 (1q42.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK1   6272
Cards
Entrez_Gene (NCBI)KCNK1  3775  potassium channel, two pore domain subfamily K, member 1
AliasesDPK; HOHO; K2P1; K2p1.1; 
KCNO1; TWIK-1; TWIK1
GeneCards (Weizmann)KCNK1
Ensembl hg19 (Hinxton)ENSG00000135750 [Gene_View]  chr1:233749750-233808258 [Contig_View]  KCNK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000135750 [Gene_View]  chr1:233749750-233808258 [Contig_View]  KCNK1 [Vega]
ICGC DataPortalENSG00000135750
TCGA cBioPortalKCNK1
AceView (NCBI)KCNK1
Genatlas (Paris)KCNK1
WikiGenes3775
SOURCE (Princeton)KCNK1
Genetics Home Reference (NIH)KCNK1
Genomic and cartography
GoldenPath hg19 (UCSC)KCNK1  -     chr1:233749750-233808258 +  1q42.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KCNK1  -     1q42.2   [Description]    (hg38-Dec_2013)
EnsemblKCNK1 - 1q42.2 [CytoView hg19]  KCNK1 - 1q42.2 [CytoView hg38]
Mapping of homologs : NCBIKCNK1 [Mapview hg19]  KCNK1 [Mapview hg38]
OMIM601745   
Gene and transcription
Genbank (Entrez)AK090902 AK314016 BC018051 BQ022191 DQ892383
RefSeq transcript (Entrez)NM_002245
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)KCNK1
Cluster EST : UnigeneHs.208544 [ NCBI ]
CGAP (NCI)Hs.208544
Alternative Splicing GalleryENSG00000135750
Gene ExpressionKCNK1 [ NCBI-GEO ]   KCNK1 [ EBI - ARRAY_EXPRESS ]   KCNK1 [ SEEK ]   KCNK1 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3775
GTEX Portal (Tissue expression)KCNK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00180   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00180  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00180
Splice isoforms : SwissVarO00180
PhosPhoSitePlusO00180
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_dom    2pore_dom_K_chnl_TASK    2pore_dom_K_chnl_TWIK    2pore_dom_K_chnl_TWIK1   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK1
DMDM Disease mutations3775
Blocks (Seattle)KCNK1
PDB (SRS)3UKM   
PDB (PDBSum)3UKM   
PDB (IMB)3UKM   
PDB (RSDB)3UKM   
Structural Biology KnowledgeBase3UKM   
SCOP (Structural Classification of Proteins)3UKM   
CATH (Classification of proteins structures)3UKM   
SuperfamilyO00180
Human Protein AtlasENSG00000135750
Peptide AtlasO00180
HPRD03447
IPIIPI00010476   IPI00645673   IPI00515043   
Protein Interaction databases
DIP (DOE-UCLA)O00180
IntAct (EBI)O00180
FunCoupENSG00000135750
BioGRIDKCNK1
STRING (EMBL)KCNK1
ZODIACKCNK1
Ontologies - Pathways
QuickGOO00180
Ontology : AmiGOinward rectifier potassium channel activity  voltage-gated potassium channel activity  potassium channel activity  sodium channel activity  endosome  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  potassium ion transport  synaptic transmission  voltage-gated potassium channel complex  integral component of membrane  apical plasma membrane  potassium ion leak channel activity  potassium ion leak channel activity  stabilization of membrane potential  brush border membrane  potassium channel complex  regulation of ion transmembrane transport  response to nicotine  sodium ion transmembrane transport  regulation of resting membrane potential  potassium ion transmembrane transport  
Ontology : EGO-EBIinward rectifier potassium channel activity  voltage-gated potassium channel activity  potassium channel activity  sodium channel activity  endosome  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  potassium ion transport  synaptic transmission  voltage-gated potassium channel complex  integral component of membrane  apical plasma membrane  potassium ion leak channel activity  potassium ion leak channel activity  stabilization of membrane potential  brush border membrane  potassium channel complex  regulation of ion transmembrane transport  response to nicotine  sodium ion transmembrane transport  regulation of resting membrane potential  potassium ion transmembrane transport  
NDEx NetworkKCNK1
Atlas of Cancer Signalling NetworkKCNK1
Wikipedia pathwaysKCNK1
Orthology - Evolution
OrthoDB3775
GeneTree (enSembl)ENSG00000135750
Phylogenetic Trees/Animal Genes : TreeFamKCNK1
HOVERGENO00180
HOGENOMO00180
Homologs : HomoloGeneKCNK1
Homology/Alignments : Family Browser (UCSC)KCNK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK1
dbVarKCNK1
ClinVarKCNK1
1000_GenomesKCNK1 
Exome Variant ServerKCNK1
ExAC (Exome Aggregation Consortium)KCNK1 (select the gene name)
Genetic variants : HAPMAP3775
Genomic Variants (DGV)KCNK1 [DGVbeta]
DECIPHER (Syndromes)1:233749750-233808258  ENSG00000135750
CONAN: Copy Number AnalysisKCNK1 
Mutations
ICGC Data PortalKCNK1 
TCGA Data PortalKCNK1 
Broad Tumor PortalKCNK1
OASIS PortalKCNK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK1
DgiDB (Drug Gene Interaction Database)KCNK1
DoCM (Curated mutations)KCNK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK1 (select a term)
intoGenKCNK1
Cancer3DKCNK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601745   
Orphanet
MedgenKCNK1
Genetic Testing Registry KCNK1
NextProtO00180 [Medical]
TSGene3775
GENETestsKCNK1
Huge Navigator KCNK1 [HugePedia]
snp3D : Map Gene to Disease3775
BioCentury BCIQKCNK1
ClinGenKCNK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3775
Chemical/Pharm GKB GenePA219
Clinical trialKCNK1
Miscellaneous
canSAR (ICR)KCNK1 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK1
EVEXKCNK1
GoPubMedKCNK1
iHOPKCNK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 12:09:27 CET 2017

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