Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK10 (potassium two pore domain channel subfamily K member 10)

Identity

Alias_namesregulatory subunit 97
Alias_symbol (synonym)K2p10.1
TREK-2
TREK2
PPP1R97
Other alias
HGNC (Hugo) KCNK10
LocusID (NCBI) 54207
Atlas_Id 53925
Location 14q31.3  [Link to chromosome band 14q31]
Location_base_pair Starts at 88180108 and ends at 88326912 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCNK10 (14q31.3) / WNK2 (9q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK10   6273
Cards
Entrez_Gene (NCBI)KCNK10  54207  potassium two pore domain channel subfamily K member 10
AliasesK2p10.1; PPP1R97; TREK-2; TREK2
GeneCards (Weizmann)KCNK10
Ensembl hg19 (Hinxton)ENSG00000100433 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100433 [Gene_View]  chr14:88180108-88326912 [Contig_View]  KCNK10 [Vega]
ICGC DataPortalENSG00000100433
TCGA cBioPortalKCNK10
AceView (NCBI)KCNK10
Genatlas (Paris)KCNK10
WikiGenes54207
SOURCE (Princeton)KCNK10
Genetics Home Reference (NIH)KCNK10
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK10  -     chr14:88180108-88326912 -  14q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK10  -     14q31.3   [Description]    (hg19-Feb_2009)
EnsemblKCNK10 - 14q31.3 [CytoView hg19]  KCNK10 - 14q31.3 [CytoView hg38]
Mapping of homologs : NCBIKCNK10 [Mapview hg19]  KCNK10 [Mapview hg38]
OMIM605873   
Gene and transcription
Genbank (Entrez)AF279890 AF385399 AF385400 AI693366 AK125389
RefSeq transcript (Entrez)NM_021161 NM_138317 NM_138318
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK10
Cluster EST : UnigeneHs.560255 [ NCBI ]
CGAP (NCI)Hs.560255
Alternative Splicing GalleryENSG00000100433
Gene ExpressionKCNK10 [ NCBI-GEO ]   KCNK10 [ EBI - ARRAY_EXPRESS ]   KCNK10 [ SEEK ]   KCNK10 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54207
GTEX Portal (Tissue expression)KCNK10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57789   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57789  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57789
Splice isoforms : SwissVarP57789
PhosPhoSitePlusP57789
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TREK    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK10
DMDM Disease mutations54207
Blocks (Seattle)KCNK10
PDB (SRS)4BW5    4XDJ    4XDK    4XDL   
PDB (PDBSum)4BW5    4XDJ    4XDK    4XDL   
PDB (IMB)4BW5    4XDJ    4XDK    4XDL   
PDB (RSDB)4BW5    4XDJ    4XDK    4XDL   
Structural Biology KnowledgeBase4BW5    4XDJ    4XDK    4XDL   
SCOP (Structural Classification of Proteins)4BW5    4XDJ    4XDK    4XDL   
CATH (Classification of proteins structures)4BW5    4XDJ    4XDK    4XDL   
SuperfamilyP57789
Human Protein AtlasENSG00000100433
Peptide AtlasP57789
HPRD12061
IPIIPI00028078   IPI00217521   IPI00465069   IPI01026087   
Protein Interaction databases
DIP (DOE-UCLA)P57789
IntAct (EBI)P57789
FunCoupENSG00000100433
BioGRIDKCNK10
STRING (EMBL)KCNK10
ZODIACKCNK10
Ontologies - Pathways
QuickGOP57789
Ontology : AmiGOvoltage-gated ion channel activity  potassium channel activity  plasma membrane  transport  signal transduction  memory  integral component of membrane  regulation of ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated ion channel activity  potassium channel activity  plasma membrane  transport  signal transduction  memory  integral component of membrane  regulation of ion transmembrane transport  potassium ion transmembrane transport  
Pathways : KEGGGastric acid secretion   
NDEx NetworkKCNK10
Atlas of Cancer Signalling NetworkKCNK10
Wikipedia pathwaysKCNK10
Orthology - Evolution
OrthoDB54207
GeneTree (enSembl)ENSG00000100433
Phylogenetic Trees/Animal Genes : TreeFamKCNK10
HOVERGENP57789
HOGENOMP57789
Homologs : HomoloGeneKCNK10
Homology/Alignments : Family Browser (UCSC)KCNK10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK10
dbVarKCNK10
ClinVarKCNK10
1000_GenomesKCNK10 
Exome Variant ServerKCNK10
ExAC (Exome Aggregation Consortium)KCNK10 (select the gene name)
Genetic variants : HAPMAP54207
Genomic Variants (DGV)KCNK10 [DGVbeta]
DECIPHERKCNK10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK10 
Mutations
ICGC Data PortalKCNK10 
TCGA Data PortalKCNK10 
Broad Tumor PortalKCNK10
OASIS PortalKCNK10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK10
DgiDB (Drug Gene Interaction Database)KCNK10
DoCM (Curated mutations)KCNK10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK10 (select a term)
intoGenKCNK10
Cancer3DKCNK10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605873   
Orphanet
MedgenKCNK10
Genetic Testing Registry KCNK10
NextProtP57789 [Medical]
TSGene54207
GENETestsKCNK10
Target ValidationKCNK10
Huge Navigator KCNK10 [HugePedia]
snp3D : Map Gene to Disease54207
BioCentury BCIQKCNK10
ClinGenKCNK10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54207
Chemical/Pharm GKB GenePA30053
Clinical trialKCNK10
Miscellaneous
canSAR (ICR)KCNK10 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK10
EVEXKCNK10
GoPubMedKCNK10
iHOPKCNK10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:39:17 CEST 2017

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