Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK10 (potassium two pore domain channel subfamily K member 10)

Identity

Alias (NCBI)K2p10.1
PPP1R97
TREK-2
TREK2
HGNC (Hugo) KCNK10
HGNC Alias symbK2p10.1
TREK-2
TREK2
PPP1R97
HGNC Alias nameprotein phosphatase 1, regulatory subunit 97
HGNC Previous namepotassium channel, subfamily K, member 10
 potassium channel, two pore domain subfamily K, member 10
LocusID (NCBI) 54207
Atlas_Id 53925
Location 14q31.3  [Link to chromosome band 14q31]
Location_base_pair Starts at 88180108 and ends at 88270911 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KCNK10 (14q31.3) / WNK2 (9q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KCNK10   6273
Cards
Entrez_Gene (NCBI)KCNK10    potassium two pore domain channel subfamily K member 10
AliasesK2p10.1; PPP1R97; TREK-2; TREK2
GeneCards (Weizmann)KCNK10
Ensembl hg19 (Hinxton)ENSG00000100433 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100433 [Gene_View]  ENSG00000100433 [Sequence]  chr14:88180108-88270911 [Contig_View]  KCNK10 [Vega]
ICGC DataPortalENSG00000100433
TCGA cBioPortalKCNK10
AceView (NCBI)KCNK10
Genatlas (Paris)KCNK10
SOURCE (Princeton)KCNK10
Genetics Home Reference (NIH)KCNK10
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK10  -     chr14:88180108-88270911 -  14q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK10  -     14q31.3   [Description]    (hg19-Feb_2009)
GoldenPathKCNK10 - 14q31.3 [CytoView hg19]  KCNK10 - 14q31.3 [CytoView hg38]
ImmunoBaseENSG00000100433
Genome Data Viewer NCBIKCNK10 [Mapview hg19]  
OMIM605873   
Gene and transcription
Genbank (Entrez)AF279890 AF385399 AF385400 AI693366 AK125389
RefSeq transcript (Entrez)NM_021161 NM_138317 NM_138318
Consensus coding sequences : CCDS (NCBI)KCNK10
Gene ExpressionKCNK10 [ NCBI-GEO ]   KCNK10 [ EBI - ARRAY_EXPRESS ]   KCNK10 [ SEEK ]   KCNK10 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK10 [ Firebrowse - Broad ]
GenevisibleExpression of KCNK10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54207
GTEX Portal (Tissue expression)KCNK10
Human Protein AtlasENSG00000100433-KCNK10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57789   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57789  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57789
PhosPhoSitePlusP57789
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TREK    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK10
PDB (RSDB)4BW5    4XDJ    4XDK    4XDL   
PDB Europe4BW5    4XDJ    4XDK    4XDL   
PDB (PDBSum)4BW5    4XDJ    4XDK    4XDL   
PDB (IMB)4BW5    4XDJ    4XDK    4XDL   
Structural Biology KnowledgeBase4BW5    4XDJ    4XDK    4XDL   
SCOP (Structural Classification of Proteins)4BW5    4XDJ    4XDK    4XDL   
CATH (Classification of proteins structures)4BW5    4XDJ    4XDK    4XDL   
SuperfamilyP57789
AlphaFold pdb e-kbP57789   
Human Protein Atlas [tissue]ENSG00000100433-KCNK10 [tissue]
HPRD12061
Protein Interaction databases
DIP (DOE-UCLA)P57789
IntAct (EBI)P57789
BioGRIDKCNK10
STRING (EMBL)KCNK10
ZODIACKCNK10
Ontologies - Pathways
QuickGOP57789
Ontology : AmiGOvoltage-gated ion channel activity  potassium channel activity  plasma membrane  integral component of plasma membrane  signal transduction  memory  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated ion channel activity  potassium channel activity  plasma membrane  integral component of plasma membrane  signal transduction  memory  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  
Pathways : KEGGGastric acid secretion   
NDEx NetworkKCNK10
Atlas of Cancer Signalling NetworkKCNK10
Wikipedia pathwaysKCNK10
Orthology - Evolution
OrthoDB54207
GeneTree (enSembl)ENSG00000100433
Phylogenetic Trees/Animal Genes : TreeFamKCNK10
Homologs : HomoloGeneKCNK10
Homology/Alignments : Family Browser (UCSC)KCNK10
Gene fusions - Rearrangements
Fusion : QuiverKCNK10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK10
dbVarKCNK10
ClinVarKCNK10
MonarchKCNK10
1000_GenomesKCNK10 
Exome Variant ServerKCNK10
GNOMAD BrowserENSG00000100433
Varsome BrowserKCNK10
ACMGKCNK10 variants
VarityP57789
Genomic Variants (DGV)KCNK10 [DGVbeta]
DECIPHERKCNK10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK10 
Mutations
ICGC Data PortalKCNK10 
TCGA Data PortalKCNK10 
Broad Tumor PortalKCNK10
OASIS PortalKCNK10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKCNK10
Mutations and Diseases : HGMDKCNK10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKCNK10
DgiDB (Drug Gene Interaction Database)KCNK10
DoCM (Curated mutations)KCNK10
CIViC (Clinical Interpretations of Variants in Cancer)KCNK10
Cancer3DKCNK10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605873   
Orphanet
DisGeNETKCNK10
MedgenKCNK10
Genetic Testing Registry KCNK10
NextProtP57789 [Medical]
GENETestsKCNK10
Target ValidationKCNK10
Huge Navigator KCNK10 [HugePedia]
ClinGenKCNK10
Clinical trials, drugs, therapy
MyCancerGenomeKCNK10
Protein Interactions : CTDKCNK10
Pharm GKB GenePA30053
PharosP57789
Clinical trialKCNK10
Miscellaneous
canSAR (ICR)KCNK10
HarmonizomeKCNK10
DataMed IndexKCNK10
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKCNK10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:42 CEST 2021

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