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KCNK12 (potassium two pore domain channel subfamily K member 12)

Identity

Alias_namespotassium channel, subfamily K, member 12
potassium channel, two pore domain subfamily K, member 12
Alias_symbol (synonym)THIK-2
THIK2
K2p12.1
Other alias
HGNC (Hugo) KCNK12
LocusID (NCBI) 56660
Atlas_Id 64794
Location 2p16.3  [Link to chromosome band 2p16]
Location_base_pair Starts at 47520776 and ends at 47570331 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK12   6274
Cards
Entrez_Gene (NCBI)KCNK12  56660  potassium two pore domain channel subfamily K member 12
AliasesK2p12.1; THIK-2; THIK2
GeneCards (Weizmann)KCNK12
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:47520776-47570331 [Contig_View]  KCNK12 [Vega]
TCGA cBioPortalKCNK12
AceView (NCBI)KCNK12
Genatlas (Paris)KCNK12
WikiGenes56660
SOURCE (Princeton)KCNK12
Genetics Home Reference (NIH)KCNK12
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK12  -     chr2:47520776-47570331 -  2p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK12  -     2p16.3   [Description]    (hg19-Feb_2009)
EnsemblKCNK12 - 2p16.3 [CytoView hg19]  KCNK12 - 2p16.3 [CytoView hg38]
Mapping of homologs : NCBIKCNK12 [Mapview hg19]  KCNK12 [Mapview hg38]
OMIM607366   
Gene and transcription
Genbank (Entrez)AF287302 BC047749
RefSeq transcript (Entrez)NM_022055
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK12
Cluster EST : UnigeneHs.591586 [ NCBI ]
CGAP (NCI)Hs.591586
Gene ExpressionKCNK12 [ NCBI-GEO ]   KCNK12 [ EBI - ARRAY_EXPRESS ]   KCNK12 [ SEEK ]   KCNK12 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56660
GTEX Portal (Tissue expression)KCNK12
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HB15   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HB15  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HB15
Splice isoforms : SwissVarQ9HB15
PhosPhoSitePlusQ9HB15
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_THIK    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK12
DMDM Disease mutations56660
Blocks (Seattle)KCNK12
SuperfamilyQ9HB15
Peptide AtlasQ9HB15
HPRD09562
IPIIPI00004933   
Protein Interaction databases
DIP (DOE-UCLA)Q9HB15
IntAct (EBI)Q9HB15
BioGRIDKCNK12
STRING (EMBL)KCNK12
ZODIACKCNK12
Ontologies - Pathways
QuickGOQ9HB15
Ontology : AmiGOvoltage-gated ion channel activity  potassium channel activity  integral component of membrane  regulation of ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated ion channel activity  potassium channel activity  integral component of membrane  regulation of ion transmembrane transport  potassium ion transmembrane transport  
NDEx NetworkKCNK12
Atlas of Cancer Signalling NetworkKCNK12
Wikipedia pathwaysKCNK12
Orthology - Evolution
OrthoDB56660
Phylogenetic Trees/Animal Genes : TreeFamKCNK12
HOVERGENQ9HB15
HOGENOMQ9HB15
Homologs : HomoloGeneKCNK12
Homology/Alignments : Family Browser (UCSC)KCNK12
Gene fusions - Rearrangements
Tumor Fusion PortalKCNK12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK12
dbVarKCNK12
ClinVarKCNK12
1000_GenomesKCNK12 
Exome Variant ServerKCNK12
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP56660
Genomic Variants (DGV)KCNK12 [DGVbeta]
DECIPHERKCNK12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK12 
Mutations
ICGC Data PortalKCNK12 
TCGA Data PortalKCNK12 
Broad Tumor PortalKCNK12
OASIS PortalKCNK12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK12
DgiDB (Drug Gene Interaction Database)KCNK12
DoCM (Curated mutations)KCNK12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK12 (select a term)
intoGenKCNK12
Cancer3DKCNK12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607366   
Orphanet
DisGeNETKCNK12
MedgenKCNK12
Genetic Testing Registry KCNK12
NextProtQ9HB15 [Medical]
TSGene56660
GENETestsKCNK12
Target ValidationKCNK12
Huge Navigator KCNK12 [HugePedia]
snp3D : Map Gene to Disease56660
BioCentury BCIQKCNK12
ClinGenKCNK12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56660
Chemical/Pharm GKB GenePA30054
Clinical trialKCNK12
Miscellaneous
canSAR (ICR)KCNK12 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK12
EVEXKCNK12
GoPubMedKCNK12
iHOPKCNK12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:04:47 CET 2017

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