Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK17 (potassium two pore domain channel subfamily K member 17)

Identity

Alias_namespotassium channel, subfamily K, member 17
potassium channel, two pore domain subfamily K, member 17
Alias_symbol (synonym)K2p17.1
TALK-2
TALK2
TASK4
TASK-4
Other alias
HGNC (Hugo) KCNK17
LocusID (NCBI) 89822
Atlas_Id 54393
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 39299001 and ends at 39314460 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRLS1 (20p12.3) / KCNK17 (6p21.2)KCNK17 (6p21.2) / KIF6 (6p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p21) KCNK17/KIF6


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Small Cell Carcinoma
t(6;20)(p21;p12) CRLS1/KCNK17


External links

Nomenclature
HGNC (Hugo)KCNK17   14465
Cards
Entrez_Gene (NCBI)KCNK17  89822  potassium two pore domain channel subfamily K member 17
AliasesK2p17.1; TALK-2; TALK2; TASK-4; 
TASK4
GeneCards (Weizmann)KCNK17
Ensembl hg19 (Hinxton)ENSG00000124780 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124780 [Gene_View]  ENSG00000124780 [Sequence]  chr6:39299001-39314460 [Contig_View]  KCNK17 [Vega]
ICGC DataPortalENSG00000124780
TCGA cBioPortalKCNK17
AceView (NCBI)KCNK17
Genatlas (Paris)KCNK17
WikiGenes89822
SOURCE (Princeton)KCNK17
Genetics Home Reference (NIH)KCNK17
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK17  -     chr6:39299001-39314460 -  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK17  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblKCNK17 - 6p21.2 [CytoView hg19]  KCNK17 - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIKCNK17 [Mapview hg19]  KCNK17 [Mapview hg38]
OMIM607370   
Gene and transcription
Genbank (Entrez)AF339912 AF358910 AK310582 AK315273 AY358853
RefSeq transcript (Entrez)NM_001135111 NM_031460
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK17
Cluster EST : UnigeneHs.162282 [ NCBI ]
CGAP (NCI)Hs.162282
Alternative Splicing GalleryENSG00000124780
Gene ExpressionKCNK17 [ NCBI-GEO ]   KCNK17 [ EBI - ARRAY_EXPRESS ]   KCNK17 [ SEEK ]   KCNK17 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK17 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89822
GTEX Portal (Tissue expression)KCNK17
Human Protein AtlasENSG00000124780-KCNK17 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96T54   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96T54  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96T54
Splice isoforms : SwissVarQ96T54
PhosPhoSitePlusQ96T54
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TASK    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK17
DMDM Disease mutations89822
Blocks (Seattle)KCNK17
SuperfamilyQ96T54
Human Protein Atlas [tissue]ENSG00000124780-KCNK17 [tissue]
Peptide AtlasQ96T54
HPRD09566
IPIIPI00027805   IPI00221147   IPI00913858   
Protein Interaction databases
DIP (DOE-UCLA)Q96T54
IntAct (EBI)Q96T54
FunCoupENSG00000124780
BioGRIDKCNK17
STRING (EMBL)KCNK17
ZODIACKCNK17
Ontologies - Pathways
QuickGOQ96T54
Ontology : AmiGOvoltage-gated ion channel activity  potassium channel activity  potassium channel activity  plasma membrane  integral component of plasma membrane  potassium ion transport  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated ion channel activity  potassium channel activity  potassium channel activity  plasma membrane  integral component of plasma membrane  potassium ion transport  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  
NDEx NetworkKCNK17
Atlas of Cancer Signalling NetworkKCNK17
Wikipedia pathwaysKCNK17
Orthology - Evolution
OrthoDB89822
GeneTree (enSembl)ENSG00000124780
Phylogenetic Trees/Animal Genes : TreeFamKCNK17
HOVERGENQ96T54
HOGENOMQ96T54
Homologs : HomoloGeneKCNK17
Homology/Alignments : Family Browser (UCSC)KCNK17
Gene fusions - Rearrangements
Fusion : MitelmanCRLS1/KCNK17 [20p12.3/6p21.2]  [t(6;20)(p21;p12)]  
Fusion : MitelmanKCNK17/KIF6 [6p21.2/6p21.2]  [t(6;6)(p21;p21)]  
Fusion : QuiverKCNK17
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK17
dbVarKCNK17
ClinVarKCNK17
1000_GenomesKCNK17 
Exome Variant ServerKCNK17
ExAC (Exome Aggregation Consortium)ENSG00000124780
GNOMAD BrowserENSG00000124780
Varsome BrowserKCNK17
Genetic variants : HAPMAP89822
Genomic Variants (DGV)KCNK17 [DGVbeta]
DECIPHERKCNK17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK17 
Mutations
ICGC Data PortalKCNK17 
TCGA Data PortalKCNK17 
Broad Tumor PortalKCNK17
OASIS PortalKCNK17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK17  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK17
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK17
DgiDB (Drug Gene Interaction Database)KCNK17
DoCM (Curated mutations)KCNK17 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK17 (select a term)
intoGenKCNK17
Cancer3DKCNK17(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607370   
Orphanet
DisGeNETKCNK17
MedgenKCNK17
Genetic Testing Registry KCNK17
NextProtQ96T54 [Medical]
TSGene89822
GENETestsKCNK17
Target ValidationKCNK17
Huge Navigator KCNK17 [HugePedia]
snp3D : Map Gene to Disease89822
BioCentury BCIQKCNK17
ClinGenKCNK17
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89822
Chemical/Pharm GKB GenePA30058
Clinical trialKCNK17
Miscellaneous
canSAR (ICR)KCNK17 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK17
EVEXKCNK17
GoPubMedKCNK17
iHOPKCNK17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:30:16 CEST 2018

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