Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK18 (potassium two pore domain channel subfamily K member 18)

Identity

Alias_namespotassium channel, subfamily K, member 18
potassium channel, two pore domain subfamily K, member 18
Alias_symbol (synonym)K2p18.1
TRESK-2
TRESK2
TRESK
TRIK
Other aliasMGR13
HGNC (Hugo) KCNK18
LocusID (NCBI) 338567
Atlas_Id 53435
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 117197489 and ends at 117210299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK18   19439
Cards
Entrez_Gene (NCBI)KCNK18  338567  potassium two pore domain channel subfamily K member 18
AliasesK2p18.1; MGR13; TRESK; TRESK-2; 
TRESK2; TRIK
GeneCards (Weizmann)KCNK18
Ensembl hg19 (Hinxton)ENSG00000186795 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186795 [Gene_View]  chr10:117197489-117210299 [Contig_View]  KCNK18 [Vega]
ICGC DataPortalENSG00000186795
TCGA cBioPortalKCNK18
AceView (NCBI)KCNK18
Genatlas (Paris)KCNK18
WikiGenes338567
SOURCE (Princeton)KCNK18
Genetics Home Reference (NIH)KCNK18
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK18  -     chr10:117197489-117210299 +  10q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK18  -     10q25.3   [Description]    (hg19-Feb_2009)
EnsemblKCNK18 - 10q25.3 [CytoView hg19]  KCNK18 - 10q25.3 [CytoView hg38]
Mapping of homologs : NCBIKCNK18 [Mapview hg19]  KCNK18 [Mapview hg38]
OMIM613655   613656   
Gene and transcription
Genbank (Entrez)AB087138 BC148337 BC152979
RefSeq transcript (Entrez)NM_181840
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK18
Cluster EST : UnigeneHs.449650 [ NCBI ]
CGAP (NCI)Hs.449650
Alternative Splicing GalleryENSG00000186795
Gene ExpressionKCNK18 [ NCBI-GEO ]   KCNK18 [ EBI - ARRAY_EXPRESS ]   KCNK18 [ SEEK ]   KCNK18 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)338567
GTEX Portal (Tissue expression)KCNK18
Human Protein AtlasENSG00000186795-KCNK18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z418   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z418  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z418
Splice isoforms : SwissVarQ7Z418
PhosPhoSitePlusQ7Z418
Domains : Interpro (EBI)2pore_dom_K_chnl    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK18
DMDM Disease mutations338567
Blocks (Seattle)KCNK18
SuperfamilyQ7Z418
Human Protein Atlas [tissue]ENSG00000186795-KCNK18 [tissue]
Peptide AtlasQ7Z418
HPRD17173
IPIIPI00375859   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z418
IntAct (EBI)Q7Z418
FunCoupENSG00000186795
BioGRIDKCNK18
STRING (EMBL)KCNK18
ZODIACKCNK18
Ontologies - Pathways
QuickGOQ7Z418
Ontology : AmiGOpotassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  potassium ion transport  calcium-activated potassium channel activity  outward rectifier potassium channel activity  potassium ion export  cellular response to pH  
Ontology : EGO-EBIpotassium channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  potassium ion transport  calcium-activated potassium channel activity  outward rectifier potassium channel activity  potassium ion export  cellular response to pH  
NDEx NetworkKCNK18
Atlas of Cancer Signalling NetworkKCNK18
Wikipedia pathwaysKCNK18
Orthology - Evolution
OrthoDB338567
GeneTree (enSembl)ENSG00000186795
Phylogenetic Trees/Animal Genes : TreeFamKCNK18
HOVERGENQ7Z418
HOGENOMQ7Z418
Homologs : HomoloGeneKCNK18
Homology/Alignments : Family Browser (UCSC)KCNK18
Gene fusions - Rearrangements
Tumor Fusion PortalKCNK18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK18
dbVarKCNK18
ClinVarKCNK18
1000_GenomesKCNK18 
Exome Variant ServerKCNK18
ExAC (Exome Aggregation Consortium)ENSG00000186795
GNOMAD BrowserENSG00000186795
Genetic variants : HAPMAP338567
Genomic Variants (DGV)KCNK18 [DGVbeta]
DECIPHERKCNK18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK18 
Mutations
ICGC Data PortalKCNK18 
TCGA Data PortalKCNK18 
Broad Tumor PortalKCNK18
OASIS PortalKCNK18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK18
DgiDB (Drug Gene Interaction Database)KCNK18
DoCM (Curated mutations)KCNK18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK18 (select a term)
intoGenKCNK18
Cancer3DKCNK18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613655    613656   
Orphanet
DisGeNETKCNK18
MedgenKCNK18
Genetic Testing Registry KCNK18
NextProtQ7Z418 [Medical]
TSGene338567
GENETestsKCNK18
Target ValidationKCNK18
Huge Navigator KCNK18 [HugePedia]
snp3D : Map Gene to Disease338567
BioCentury BCIQKCNK18
ClinGenKCNK18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD338567
Chemical/Pharm GKB GenePA134985465
Clinical trialKCNK18
Miscellaneous
canSAR (ICR)KCNK18 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK18
EVEXKCNK18
GoPubMedKCNK18
iHOPKCNK18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:18:37 CET 2017

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