Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK2 (potassium two pore domain channel subfamily K member 2)

Identity

Alias_namespotassium channel, subfamily K, member 2
potassium channel, two pore domain subfamily K, member 2
Alias_symbol (synonym)K2p2.1
TREK-1
Other aliasTPKC1
TREK
TREK1
hTREK-1c
hTREK-1e
HGNC (Hugo) KCNK2
LocusID (NCBI) 3776
Atlas_Id 53934
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 215178885 and ends at 215410436 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KCNK2 (1q41) / PITPNC1 (17q24.2)KCNK2 (1q41) / SFTPB (2p11.2)KCNK2 (1q41) / TMBIM6 (12q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK2   6277
Cards
Entrez_Gene (NCBI)KCNK2  3776  potassium two pore domain channel subfamily K member 2
AliasesK2p2.1; TPKC1; TREK; TREK-1; 
TREK1; hTREK-1c; hTREK-1e
GeneCards (Weizmann)KCNK2
Ensembl hg19 (Hinxton)ENSG00000082482 [Gene_View]  chr1:215178885-215410436 [Contig_View]  KCNK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000082482 [Gene_View]  chr1:215178885-215410436 [Contig_View]  KCNK2 [Vega]
ICGC DataPortalENSG00000082482
TCGA cBioPortalKCNK2
AceView (NCBI)KCNK2
Genatlas (Paris)KCNK2
WikiGenes3776
SOURCE (Princeton)KCNK2
Genetics Home Reference (NIH)KCNK2
Genomic and cartography
GoldenPath hg19 (UCSC)KCNK2  -     chr1:215178885-215410436 +  1q41   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KCNK2  -     1q41   [Description]    (hg38-Dec_2013)
EnsemblKCNK2 - 1q41 [CytoView hg19]  KCNK2 - 1q41 [CytoView hg38]
Mapping of homologs : NCBIKCNK2 [Mapview hg19]  KCNK2 [Mapview hg38]
OMIM603219   
Gene and transcription
Genbank (Entrez)AF004711 AF129399 AF171068 AK123409 AK291483
RefSeq transcript (Entrez)NM_001017424 NM_001017425 NM_014217
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929294
Consensus coding sequences : CCDS (NCBI)KCNK2
Cluster EST : UnigeneHs.497745 [ NCBI ]
CGAP (NCI)Hs.497745
Alternative Splicing GalleryENSG00000082482
Gene ExpressionKCNK2 [ NCBI-GEO ]   KCNK2 [ EBI - ARRAY_EXPRESS ]   KCNK2 [ SEEK ]   KCNK2 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3776
GTEX Portal (Tissue expression)KCNK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95069   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95069  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95069
Splice isoforms : SwissVarO95069
PhosPhoSitePlusO95069
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TREK    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK2
DMDM Disease mutations3776
Blocks (Seattle)KCNK2
PDB (SRS)4TWK   
PDB (PDBSum)4TWK   
PDB (IMB)4TWK   
PDB (RSDB)4TWK   
Structural Biology KnowledgeBase4TWK   
SCOP (Structural Classification of Proteins)4TWK   
CATH (Classification of proteins structures)4TWK   
SuperfamilyO95069
Human Protein AtlasENSG00000082482
Peptide AtlasO95069
IPIIPI00028268   IPI00844492   IPI00829643   IPI00329550   IPI00945018   IPI00945345   IPI00909558   IPI00946089   IPI01009327   
Protein Interaction databases
DIP (DOE-UCLA)O95069
IntAct (EBI)O95069
FunCoupENSG00000082482
BioGRIDKCNK2
STRING (EMBL)KCNK2
ZODIACKCNK2
Ontologies - Pathways
QuickGOO95069
Ontology : AmiGOcardiac ventricle development  nucleus  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  memory  voltage-gated potassium channel complex  response to mechanical stimulus  cell surface  positive regulation of cell death  outward rectifier potassium channel activity  outward rectifier potassium channel activity  apical plasma membrane  potassium channel inhibitor activity  potassium channel inhibitor activity  potassium ion leak channel activity  potassium ion leak channel activity  stabilization of membrane potential  neuronal cell body  calyx of Held  response to axon injury  negative regulation of cardiac muscle cell proliferation  cellular response to hypoxia  potassium ion transmembrane transport  cochlea development  astrocyte projection  positive regulation of cellular response to hypoxia  negative regulation of DNA biosynthetic process  
Ontology : EGO-EBIcardiac ventricle development  nucleus  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  memory  voltage-gated potassium channel complex  response to mechanical stimulus  cell surface  positive regulation of cell death  outward rectifier potassium channel activity  outward rectifier potassium channel activity  apical plasma membrane  potassium channel inhibitor activity  potassium channel inhibitor activity  potassium ion leak channel activity  potassium ion leak channel activity  stabilization of membrane potential  neuronal cell body  calyx of Held  response to axon injury  negative regulation of cardiac muscle cell proliferation  cellular response to hypoxia  potassium ion transmembrane transport  cochlea development  astrocyte projection  positive regulation of cellular response to hypoxia  negative regulation of DNA biosynthetic process  
Pathways : KEGGGastric acid secretion   
NDEx NetworkKCNK2
Atlas of Cancer Signalling NetworkKCNK2
Wikipedia pathwaysKCNK2
Orthology - Evolution
OrthoDB3776
GeneTree (enSembl)ENSG00000082482
Phylogenetic Trees/Animal Genes : TreeFamKCNK2
HOVERGENO95069
HOGENOMO95069
Homologs : HomoloGeneKCNK2
Homology/Alignments : Family Browser (UCSC)KCNK2
Gene fusions - Rearrangements
Fusion Cancer (Beijing)KCNK2 [1q41]  -  SFTPB [2p11.2]  [FUSC003079]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK2
dbVarKCNK2
ClinVarKCNK2
1000_GenomesKCNK2 
Exome Variant ServerKCNK2
ExAC (Exome Aggregation Consortium)KCNK2 (select the gene name)
Genetic variants : HAPMAP3776
Genomic Variants (DGV)KCNK2 [DGVbeta]
DECIPHER (Syndromes)1:215178885-215410436  ENSG00000082482
CONAN: Copy Number AnalysisKCNK2 
Mutations
ICGC Data PortalKCNK2 
TCGA Data PortalKCNK2 
Broad Tumor PortalKCNK2
OASIS PortalKCNK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK2
DgiDB (Drug Gene Interaction Database)KCNK2
DoCM (Curated mutations)KCNK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK2 (select a term)
intoGenKCNK2
Cancer3DKCNK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603219   
Orphanet
MedgenKCNK2
Genetic Testing Registry KCNK2
NextProtO95069 [Medical]
TSGene3776
GENETestsKCNK2
Huge Navigator KCNK2 [HugePedia]
snp3D : Map Gene to Disease3776
BioCentury BCIQKCNK2
ClinGenKCNK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3776
Chemical/Pharm GKB GenePA30059
Clinical trialKCNK2
Miscellaneous
canSAR (ICR)KCNK2 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK2
EVEXKCNK2
GoPubMedKCNK2
iHOPKCNK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:54 CEST 2017

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