Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK3 (potassium two pore domain channel subfamily K member 3)

Identity

Alias_namespotassium channel, subfamily K, member 3
potassium channel, two pore domain subfamily K, member 3
Alias_symbol (synonym)K2p3.1
TASK
TASK-1
Other aliasOAT1
PPH4
TBAK1
HGNC (Hugo) KCNK3
LocusID (NCBI) 3777
Atlas_Id 56262
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 26692713 and ends at 26731198 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZNF512 (2p23.3) / KCNK3 (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK3   6278
Cards
Entrez_Gene (NCBI)KCNK3  3777  potassium two pore domain channel subfamily K member 3
AliasesK2p3.1; OAT1; PPH4; TASK; 
TASK-1; TBAK1
GeneCards (Weizmann)KCNK3
Ensembl hg19 (Hinxton)ENSG00000171303 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171303 [Gene_View]  chr2:26692713-26731198 [Contig_View]  KCNK3 [Vega]
ICGC DataPortalENSG00000171303
TCGA cBioPortalKCNK3
AceView (NCBI)KCNK3
Genatlas (Paris)KCNK3
WikiGenes3777
SOURCE (Princeton)KCNK3
Genetics Home Reference (NIH)KCNK3
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK3  -     chr2:26692713-26731198 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK3  -     2p23.3   [Description]    (hg19-Feb_2009)
EnsemblKCNK3 - 2p23.3 [CytoView hg19]  KCNK3 - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIKCNK3 [Mapview hg19]  KCNK3 [Mapview hg38]
OMIM603220   615344   
Gene and transcription
Genbank (Entrez)AF006823 AF065163 AK123673 BC140701
RefSeq transcript (Entrez)NM_002246
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK3
Cluster EST : UnigeneHs.645288 [ NCBI ]
CGAP (NCI)Hs.645288
Alternative Splicing GalleryENSG00000171303
Gene ExpressionKCNK3 [ NCBI-GEO ]   KCNK3 [ EBI - ARRAY_EXPRESS ]   KCNK3 [ SEEK ]   KCNK3 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3777
GTEX Portal (Tissue expression)KCNK3
Human Protein AtlasENSG00000171303-KCNK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14649   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14649  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14649
Splice isoforms : SwissVarO14649
PhosPhoSitePlusO14649
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TASK    IGF-I    K_chnl_dom    KCNK3   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK3
DMDM Disease mutations3777
Blocks (Seattle)KCNK3
SuperfamilyO14649
Human Protein Atlas [tissue]ENSG00000171303-KCNK3 [tissue]
Peptide AtlasO14649
HPRD04451
IPIIPI00023110   IPI01010994   
Protein Interaction databases
DIP (DOE-UCLA)O14649
IntAct (EBI)O14649
FunCoupENSG00000171303
BioGRIDKCNK3
STRING (EMBL)KCNK3
ZODIACKCNK3
Ontologies - Pathways
QuickGOO14649
Ontology : AmiGOion channel activity  open rectifier potassium channel activity  potassium channel activity  extracellular space  plasma membrane  plasma membrane  integral component of plasma membrane  potassium ion transport  chemical synaptic transmission  brain development  protein C-terminus binding  growth factor activity  potassium ion leak channel activity  ion transmembrane transport  response to drug  protein homodimerization activity  S100 protein binding  protein heterodimerization activity  negative regulation of cytosolic calcium ion concentration  cardiac conduction  cellular response to zinc ion  cellular response to hypoxia  potassium ion transmembrane transport  cochlea development  
Ontology : EGO-EBIion channel activity  open rectifier potassium channel activity  potassium channel activity  extracellular space  plasma membrane  plasma membrane  integral component of plasma membrane  potassium ion transport  chemical synaptic transmission  brain development  protein C-terminus binding  growth factor activity  potassium ion leak channel activity  ion transmembrane transport  response to drug  protein homodimerization activity  S100 protein binding  protein heterodimerization activity  negative regulation of cytosolic calcium ion concentration  cardiac conduction  cellular response to zinc ion  cellular response to hypoxia  potassium ion transmembrane transport  cochlea development  
NDEx NetworkKCNK3
Atlas of Cancer Signalling NetworkKCNK3
Wikipedia pathwaysKCNK3
Orthology - Evolution
OrthoDB3777
GeneTree (enSembl)ENSG00000171303
Phylogenetic Trees/Animal Genes : TreeFamKCNK3
HOVERGENO14649
HOGENOMO14649
Homologs : HomoloGeneKCNK3
Homology/Alignments : Family Browser (UCSC)KCNK3
Gene fusions - Rearrangements
Fusion: Tumor Portal KCNK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK3
dbVarKCNK3
ClinVarKCNK3
1000_GenomesKCNK3 
Exome Variant ServerKCNK3
ExAC (Exome Aggregation Consortium)ENSG00000171303
GNOMAD BrowserENSG00000171303
Genetic variants : HAPMAP3777
Genomic Variants (DGV)KCNK3 [DGVbeta]
DECIPHERKCNK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK3 
Mutations
ICGC Data PortalKCNK3 
TCGA Data PortalKCNK3 
Broad Tumor PortalKCNK3
OASIS PortalKCNK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK3
DgiDB (Drug Gene Interaction Database)KCNK3
DoCM (Curated mutations)KCNK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK3 (select a term)
intoGenKCNK3
Cancer3DKCNK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603220    615344   
Orphanet20328   
MedgenKCNK3
Genetic Testing Registry KCNK3
NextProtO14649 [Medical]
TSGene3777
GENETestsKCNK3
Target ValidationKCNK3
Huge Navigator KCNK3 [HugePedia]
snp3D : Map Gene to Disease3777
BioCentury BCIQKCNK3
ClinGenKCNK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3777
Chemical/Pharm GKB GenePA30060
Clinical trialKCNK3
Miscellaneous
canSAR (ICR)KCNK3 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK3
EVEXKCNK3
GoPubMedKCNK3
iHOPKCNK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:55:11 CET 2017

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