KCNK3 (potassium two pore domain channel subfamily K member 3)

2016-10-01  

Identity

HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
K2p3.1,OAT1,PPH4,TASK,TASK-1,TASK1,TBAK1
FUSION GENES

Other Information

Locus ID:

NCBI: 3777
MIM: 603220
HGNC: 6278
Ensembl: ENSG00000171303

Variants:

dbSNP: 3777
ClinVar: 3777
TCGA: ENSG00000171303
COSMIC: KCNK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171303ENST00000302909O14649
ENSG00000171303ENST00000620977B9EIJ4

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Tandem pore domain potassium channelsREACTOMER-HSA-1296346
TWIK-releated acid-sensitive K+ channel (TASK)REACTOMER-HSA-1299316
Muscle contractionREACTOMER-HSA-397014
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD31327267
PA448765candesartanChemicalClinicalAnnotationassociatedPD31327267

References

Pubmed IDYearTitleCitations
238833802013A novel channelopathy in pulmonary arterial hypertension.110
124379302002Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.92
150995242004Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel.65
165749082006Impact of TASK-1 in human pulmonary artery smooth muscle cells.57
118868612002Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action.55
121981462002p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1.55
259518342015Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation.34
179453572007The TASK background K2P channels: chemo- and nutrient sensors.32
183759522008TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions.30
119071682002Gender-specific and developmental influences on the expression of rat organic anion transporters.29

Citation

Dessen P

KCNK3 (potassium two pore domain channel subfamily K member 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56262/kcnk3