Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KCNK4 (potassium two pore domain channel subfamily K member 4)

Identity

Alias_namespotassium channel, subfamily K, member 4
potassium channel, two pore domain subfamily K, member 4
Alias_symbol (synonym)K2p4.1
TRAAK
Other aliasTRAAK1
HGNC (Hugo) KCNK4
LocusID (NCBI) 50801
Atlas_Id 54394
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64291321 and ends at 64300031 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SYT7 (11q12.2) / KCNK4 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q12;q13) SYT7/KCNK4

External links

Nomenclature
HGNC (Hugo)KCNK4   6279
Cards
Entrez_Gene (NCBI)KCNK4  50801  potassium two pore domain channel subfamily K member 4
AliasesK2p4.1; TRAAK; TRAAK1
GeneCards (Weizmann)KCNK4
Ensembl hg19 (Hinxton)ENSG00000182450 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182450 [Gene_View]  ENSG00000182450 [Sequence]  chr11:64291321-64300031 [Contig_View]  KCNK4 [Vega]
ICGC DataPortalENSG00000182450
TCGA cBioPortalKCNK4
AceView (NCBI)KCNK4
Genatlas (Paris)KCNK4
WikiGenes50801
SOURCE (Princeton)KCNK4
Genetics Home Reference (NIH)KCNK4
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK4  -     chr11:64291321-64300031 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK4  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblKCNK4 - 11q13.1 [CytoView hg19]  KCNK4 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIKCNK4 [Mapview hg19]  KCNK4 [Mapview hg38]
OMIM605720   
Gene and transcription
Genbank (Entrez)AF248242 AF259500 AK296021 AK307135 AK309443
RefSeq transcript (Entrez)NM_001317090 NM_016611 NM_033310
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK4
Cluster EST : UnigeneHs.647233 [ NCBI ]
CGAP (NCI)Hs.647233
Alternative Splicing GalleryENSG00000182450
Gene ExpressionKCNK4 [ NCBI-GEO ]   KCNK4 [ EBI - ARRAY_EXPRESS ]   KCNK4 [ SEEK ]   KCNK4 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50801
GTEX Portal (Tissue expression)KCNK4
Human Protein AtlasENSG00000182450-KCNK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYG8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYG8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYG8
Splice isoforms : SwissVarQ9NYG8
PhosPhoSitePlusQ9NYG8
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TRAAK    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK4
DMDM Disease mutations50801
Blocks (Seattle)KCNK4
PDB (RSDB)3UM7    4I9W    4RUE    4RUF    4WFE    4WFF    4WFG    4WFH   
PDB Europe3UM7    4I9W    4RUE    4RUF    4WFE    4WFF    4WFG    4WFH   
PDB (PDBSum)3UM7    4I9W    4RUE    4RUF    4WFE    4WFF    4WFG    4WFH   
PDB (IMB)3UM7    4I9W    4RUE    4RUF    4WFE    4WFF    4WFG    4WFH   
Structural Biology KnowledgeBase3UM7    4I9W    4RUE    4RUF    4WFE    4WFF    4WFG    4WFH   
SCOP (Structural Classification of Proteins)3UM7    4I9W    4RUE    4RUF    4WFE    4WFF    4WFG    4WFH   
CATH (Classification of proteins structures)3UM7    4I9W    4RUE    4RUF    4WFE    4WFF    4WFG    4WFH   
SuperfamilyQ9NYG8
Human Protein Atlas [tissue]ENSG00000182450-KCNK4 [tissue]
Peptide AtlasQ9NYG8
HPRD12037
IPIIPI00020981   IPI00414796   IPI01019021   IPI01014701   IPI00908542   IPI01014953   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYG8
IntAct (EBI)Q9NYG8
FunCoupENSG00000182450
BioGRIDKCNK4
STRING (EMBL)KCNK4
ZODIACKCNK4
Ontologies - Pathways
QuickGOQ9NYG8
Ontology : AmiGOvoltage-gated ion channel activity  potassium channel activity  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  potassium ion transport  memory  sensory perception of pain  potassium ion leak channel activity  stabilization of membrane potential  potassium channel complex  regulation of ion transmembrane transport  sensory perception of temperature stimulus  detection of mechanical stimulus involved in sensory perception of touch  cellular response to mechanical stimulus  cellular response to fatty acid  cellular response to alkaline pH  cellular response to temperature stimulus  potassium ion transmembrane transport  potassium ion transmembrane transport  temperature-gated cation channel activity  mechanosensitived potassium channel activity  
Ontology : EGO-EBIvoltage-gated ion channel activity  potassium channel activity  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  potassium ion transport  memory  sensory perception of pain  potassium ion leak channel activity  stabilization of membrane potential  potassium channel complex  regulation of ion transmembrane transport  sensory perception of temperature stimulus  detection of mechanical stimulus involved in sensory perception of touch  cellular response to mechanical stimulus  cellular response to fatty acid  cellular response to alkaline pH  cellular response to temperature stimulus  potassium ion transmembrane transport  potassium ion transmembrane transport  temperature-gated cation channel activity  mechanosensitived potassium channel activity  
NDEx NetworkKCNK4
Atlas of Cancer Signalling NetworkKCNK4
Wikipedia pathwaysKCNK4
Orthology - Evolution
OrthoDB50801
GeneTree (enSembl)ENSG00000182450
Phylogenetic Trees/Animal Genes : TreeFamKCNK4
HOGENOMQ9NYG8
Homologs : HomoloGeneKCNK4
Homology/Alignments : Family Browser (UCSC)KCNK4
Gene fusions - Rearrangements
Fusion : MitelmanSYT7/KCNK4 [11q12.2/11q13.1]  [t(11;11)(q12;q13)]  
Fusion : QuiverKCNK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK4
dbVarKCNK4
ClinVarKCNK4
1000_GenomesKCNK4 
Exome Variant ServerKCNK4
ExAC (Exome Aggregation Consortium)ENSG00000182450
GNOMAD BrowserENSG00000182450
Varsome BrowserKCNK4
Genetic variants : HAPMAP50801
Genomic Variants (DGV)KCNK4 [DGVbeta]
DECIPHERKCNK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK4 
Mutations
ICGC Data PortalKCNK4 
TCGA Data PortalKCNK4 
Broad Tumor PortalKCNK4
OASIS PortalKCNK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK4
DgiDB (Drug Gene Interaction Database)KCNK4
DoCM (Curated mutations)KCNK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK4 (select a term)
intoGenKCNK4
Cancer3DKCNK4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605720   
Orphanet
DisGeNETKCNK4
MedgenKCNK4
Genetic Testing Registry KCNK4
NextProtQ9NYG8 [Medical]
TSGene50801
GENETestsKCNK4
Target ValidationKCNK4
Huge Navigator KCNK4 [HugePedia]
snp3D : Map Gene to Disease50801
BioCentury BCIQKCNK4
ClinGenKCNK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50801
Chemical/Pharm GKB GenePA30061
Clinical trialKCNK4
Miscellaneous
canSAR (ICR)KCNK4 (select the gene name)
DataMed IndexKCNK4
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK4
EVEXKCNK4
GoPubMedKCNK4
iHOPKCNK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:18:55 CET 2019
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