KCNK5 (potassium two pore domain channel subfamily K member 5)

2010-11-01  

Identity

HGNC
LOCATION
6p21.2
LOCUSID
ALIAS
K2p5.1,KCNK5b,TASK-2,TASK2
FUSION GENES

Other Information

Locus ID:

NCBI: 8645
MIM: 603493
HGNC: 6280
Ensembl: ENSG00000164626

Variants:

dbSNP: 8645
ClinVar: 8645
TCGA: ENSG00000164626
COSMIC: KCNK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164626ENST00000359534O95279
ENSG00000164626ENST00000359534A0A024RD32

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126349292003Determinants of pH sensing in the two-pore domain K(+) channels TASK-1 and -2.22
219644042012A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells.18
216806582011The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells.17
205829842010Upregulation of K2P5.1 potassium channels in multiple sclerosis.16
242856842014Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism.15
151974762004Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum.14
286043872017Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma.10
181578472008Potassium channels involved in human sperm volume regulation--quantitative studies at the protein and mRNA levels.9
213149282011Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients.7
249494842014NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy.7

Citation

Dessen P

KCNK5 (potassium two pore domain channel subfamily K member 5)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51772/kcnk5