Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK5 (potassium two pore domain channel subfamily K member 5)

Identity

Other namesK2p5.1
KCNK5b
TASK-2
TASK2
HGNC (Hugo) KCNK5
LocusID (NCBI) 8645
Atlas_Id 51772
Location 6p21.2
Location_base_pair Starts at 39156747 and ends at 39197251 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAMKK2 (12q24.31) / KCNK5 (6p21.2)KCNK5 (6p21.2) / KIF6 (6p21.2)KCNK5 (6p21.2) / PDE4DIP (1q21.1)
KCNK5 6p21.2 / KIF6 6p21.2KCNK5 6p21.2 / PDE4DIP 1q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK5   6280
Cards
Entrez_Gene (NCBI)KCNK5  8645  potassium two pore domain channel subfamily K member 5
GeneCards (Weizmann)KCNK5
Ensembl hg19 (Hinxton)ENSG00000164626 [Gene_View]  chr6:39156747-39197251 [Contig_View]  KCNK5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164626 [Gene_View]  chr6:39156747-39197251 [Contig_View]  KCNK5 [Vega]
ICGC DataPortalENSG00000164626
TCGA cBioPortalKCNK5
AceView (NCBI)KCNK5
Genatlas (Paris)KCNK5
WikiGenes8645
SOURCE (Princeton)KCNK5
Genomic and cartography
GoldenPath hg19 (UCSC)KCNK5  -     chr6:39156747-39197251 -  6p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KCNK5  -     6p21.2   [Description]    (hg38-Dec_2013)
EnsemblKCNK5 - 6p21.2 [CytoView hg19]  KCNK5 - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIKCNK5 [Mapview hg19]  KCNK5 [Mapview hg38]
OMIM603493   
Gene and transcription
Genbank (Entrez)AB743589 AF084830 AK001897 AK314298 BC060793
RefSeq transcript (Entrez)NM_003740
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_007592 NW_004929326
Consensus coding sequences : CCDS (NCBI)KCNK5
Cluster EST : UnigeneHs.444448 [ NCBI ]
CGAP (NCI)Hs.444448
Alternative Splicing : Fast-db (Paris)GSHG0026585
Alternative Splicing GalleryENSG00000164626
Gene ExpressionKCNK5 [ NCBI-GEO ]   KCNK5 [ EBI - ARRAY_EXPRESS ]   KCNK5 [ SEEK ]   KCNK5 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)8645
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95279 (Uniprot)
NextProtO95279  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95279
Splice isoforms : SwissVarO95279 (Swissvar)
PhosPhoSitePlusO95279
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TASK    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
DMDM Disease mutations8645
Blocks (Seattle)KCNK5
SuperfamilyO95279
Human Protein AtlasENSG00000164626
Peptide AtlasO95279
HPRD04604
IPIIPI00029507   
Protein Interaction databases
DIP (DOE-UCLA)O95279
IntAct (EBI)O95279
FunCoupENSG00000164626
BioGRIDKCNK5
STRING (EMBL)KCNK5
ZODIACKCNK5
Ontologies - Pathways
QuickGOO95279
Ontology : AmiGOvoltage-gated potassium channel activity  potassium channel activity  integral component of plasma membrane  potassium ion transport  excretion  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated potassium channel activity  potassium channel activity  integral component of plasma membrane  potassium ion transport  excretion  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  potassium ion transmembrane transport  
Pathways : KEGGProtein digestion and absorption   
NDEx Network
Atlas of Cancer Signalling NetworkKCNK5
Wikipedia pathwaysKCNK5
Orthology - Evolution
OrthoDB8645
GeneTree (enSembl)ENSG00000164626
Phylogenetic Trees/Animal Genes : TreeFamKCNK5
Homologs : HomoloGeneKCNK5
Homology/Alignments : Family Browser (UCSC)KCNK5
Gene fusions - Rearrangements
Fusion: TCGAKCNK5 6p21.2 KIF6 6p21.2 LUSC
Fusion: TCGAKCNK5 6p21.2 PDE4DIP 1q21.1 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerKCNK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK5
dbVarKCNK5
ClinVarKCNK5
1000_GenomesKCNK5 
Exome Variant ServerKCNK5
ExAC (Exome Aggregation Consortium)KCNK5 (select the gene name)
SNP (GeneSNP Utah)KCNK5
SNP : HGBaseKCNK5
Genetic variants : HAPMAPKCNK5
Genomic Variants (DGV)KCNK5 [DGVbeta]
Mutations
ICGC Data PortalKCNK5 
TCGA Data PortalKCNK5 
Broad Tumor PortalKCNK5
OASIS PortalKCNK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK5
DgiDB (Drug Gene Interaction Database)KCNK5
DoCM (Curated mutations)KCNK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK5 (select a term)
intoGenKCNK5
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:39156747-39197251
CONAN: Copy Number AnalysisKCNK5 
Mutations and Diseases : HGMDKCNK5
OMIM603493   
MedgenKCNK5
Genetic Testing Registry KCNK5
NextProtO95279 [Medical]
TSGene8645
GENETestsKCNK5
Huge Navigator KCNK5 [HugePedia]  KCNK5 [HugeCancerGEM]
snp3D : Map Gene to Disease8645
BioCentury BCIQKCNK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8645
Chemical/Pharm GKB GenePA30062
Clinical trialKCNK5
Miscellaneous
canSAR (ICR)KCNK5 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK5
GoPubMedKCNK5
iHOPKCNK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Apr 16 17:49:48 CEST 2016

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