Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KCNK6 (potassium two pore domain channel subfamily K member 6)

Identity

Alias (NCBI)K2p6.1
KCNK8
TOSS
TWIK-2
TWIK2
HGNC (Hugo) KCNK6
HGNC Alias symbK2p6.1
TWIK-2
HGNC Previous namepotassium channel, subfamily K, member 6
 potassium channel, two pore domain subfamily K, member 6
LocusID (NCBI) 9424
Atlas_Id 64799
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38319844 and ends at 38329009 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KCNK6 (19q13.2) / KCNK6 (19q13.2)LMBR1L (12q13.12) / KCNK6 (19q13.2)LOC100507412 (-) / KCNK6 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;19)(q13;q13) LMBR1L/KCNK6

External links

Nomenclature
HGNC (Hugo)KCNK6   6281
Cards
Entrez_Gene (NCBI)KCNK6    potassium two pore domain channel subfamily K member 6
AliasesK2p6.1; KCNK8; TOSS; TWIK-2; 
TWIK2
GeneCards (Weizmann)KCNK6
Ensembl hg19 (Hinxton)ENSG00000099337 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099337 [Gene_View]  ENSG00000099337 [Sequence]  chr19:38319844-38329009 [Contig_View]  KCNK6 [Vega]
ICGC DataPortalENSG00000099337
TCGA cBioPortalKCNK6
AceView (NCBI)KCNK6
Genatlas (Paris)KCNK6
SOURCE (Princeton)KCNK6
Genetics Home Reference (NIH)KCNK6
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK6  -     chr19:38319844-38329009 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK6  -     19q13.2   [Description]    (hg19-Feb_2009)
GoldenPathKCNK6 - 19q13.2 [CytoView hg19]  KCNK6 - 19q13.2 [CytoView hg38]
ImmunoBaseENSG00000099337
genome Data Viewer NCBIKCNK6 [Mapview hg19]  
OMIM603939   
Gene and transcription
Genbank (Entrez)AF117708 AF134149 AF281302 AF281303 AK022344
RefSeq transcript (Entrez)NM_004823
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK6
Alternative Splicing GalleryENSG00000099337
Gene ExpressionKCNK6 [ NCBI-GEO ]   KCNK6 [ EBI - ARRAY_EXPRESS ]   KCNK6 [ SEEK ]   KCNK6 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK6 [ Firebrowse - Broad ]
GenevisibleExpression of KCNK6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9424
GTEX Portal (Tissue expression)KCNK6
Human Protein AtlasENSG00000099337-KCNK6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y257   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y257  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y257
Splice isoforms : SwissVarQ9Y257
PhosPhoSitePlusQ9Y257
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TASK    2pore_dom_K_chnl_TWIK    2pore_dom_K_chnl_TWIK2    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK6
Blocks (Seattle)KCNK6
SuperfamilyQ9Y257
Human Protein Atlas [tissue]ENSG00000099337-KCNK6 [tissue]
Peptide AtlasQ9Y257
HPRD06803
IPIIPI00031756   IPI00216922   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y257
IntAct (EBI)Q9Y257
BioGRIDKCNK6
STRING (EMBL)KCNK6
ZODIACKCNK6
Ontologies - Pathways
QuickGOQ9Y257
Ontology : AmiGOnegative regulation of systemic arterial blood pressure  inward rectifier potassium channel activity  plasma membrane  integral component of plasma membrane  potassium ion transport  voltage-gated potassium channel complex  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  regulation of resting membrane potential  cardiac conduction  potassium ion transmembrane transport  
Ontology : EGO-EBInegative regulation of systemic arterial blood pressure  inward rectifier potassium channel activity  plasma membrane  integral component of plasma membrane  potassium ion transport  voltage-gated potassium channel complex  potassium ion leak channel activity  stabilization of membrane potential  regulation of ion transmembrane transport  regulation of resting membrane potential  cardiac conduction  potassium ion transmembrane transport  
NDEx NetworkKCNK6
Atlas of Cancer Signalling NetworkKCNK6
Wikipedia pathwaysKCNK6
Orthology - Evolution
OrthoDB9424
GeneTree (enSembl)ENSG00000099337
Phylogenetic Trees/Animal Genes : TreeFamKCNK6
HOGENOMQ9Y257
Homologs : HomoloGeneKCNK6
Homology/Alignments : Family Browser (UCSC)KCNK6
Gene fusions - Rearrangements
Fusion : QuiverKCNK6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK6 [hg38]
dbVarKCNK6
ClinVarKCNK6
MonarchKCNK6
1000_GenomesKCNK6 
Exome Variant ServerKCNK6
GNOMAD BrowserENSG00000099337
Varsome BrowserKCNK6
Genomic Variants (DGV)KCNK6 [DGVbeta]
DECIPHERKCNK6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK6 
Mutations
ICGC Data PortalKCNK6 
TCGA Data PortalKCNK6 
Broad Tumor PortalKCNK6
OASIS PortalKCNK6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKCNK6
Mutations and Diseases : HGMDKCNK6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK6
DgiDB (Drug Gene Interaction Database)KCNK6
DoCM (Curated mutations)KCNK6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK6 (select a term)
intoGenKCNK6
Cancer3DKCNK6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603939   
Orphanet
DisGeNETKCNK6
MedgenKCNK6
Genetic Testing Registry KCNK6
NextProtQ9Y257 [Medical]
GENETestsKCNK6
Target ValidationKCNK6
Huge Navigator KCNK6 [HugePedia]
ClinGenKCNK6
Clinical trials, drugs, therapy
MyCancerGenomeKCNK6
Protein Interactions : CTD
Pharm GKB GenePA30063
Clinical trialKCNK6
Miscellaneous
canSAR (ICR)KCNK6 (select the gene name)
HarmonizomeKCNK6
DataMed IndexKCNK6
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK6
EVEXKCNK6
GoPubMedKCNK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 16:58:29 CET 2020
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