Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNK6 (potassium two pore domain channel subfamily K member 6)

Identity

Alias_namespotassium channel, subfamily K, member 6
potassium channel, two pore domain subfamily K, member 6
Alias_symbol (synonym)K2p6.1
TWIK-2
Other aliasKCNK8
TOSS
TWIK2
HGNC (Hugo) KCNK6
LocusID (NCBI) 9424
Atlas_Id 64799
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38319844 and ends at 38329009 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KCNK6 (19q13.2) / KCNK6 (19q13.2)LMBR1L (12q13.12) / KCNK6 (19q13.2)LOC100507412 (-) / KCNK6 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNK6   6281
Cards
Entrez_Gene (NCBI)KCNK6  9424  potassium two pore domain channel subfamily K member 6
AliasesK2p6.1; KCNK8; TOSS; TWIK-2; 
TWIK2
GeneCards (Weizmann)KCNK6
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr19:38319844-38329009 [Contig_View]  KCNK6 [Vega]
TCGA cBioPortalKCNK6
AceView (NCBI)KCNK6
Genatlas (Paris)KCNK6
WikiGenes9424
SOURCE (Princeton)KCNK6
Genetics Home Reference (NIH)KCNK6
Genomic and cartography
GoldenPath hg38 (UCSC)KCNK6  -     chr19:38319844-38329009 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNK6  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblKCNK6 - 19q13.2 [CytoView hg19]  KCNK6 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIKCNK6 [Mapview hg19]  KCNK6 [Mapview hg38]
OMIM603939   
Gene and transcription
Genbank (Entrez)AF117708 AF134149 AF281302 AF281303 AK022344
RefSeq transcript (Entrez)NM_004823
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNK6
Cluster EST : UnigeneHs.240395 [ NCBI ]
CGAP (NCI)Hs.240395
Gene ExpressionKCNK6 [ NCBI-GEO ]   KCNK6 [ EBI - ARRAY_EXPRESS ]   KCNK6 [ SEEK ]   KCNK6 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNK6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9424
GTEX Portal (Tissue expression)KCNK6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y257   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y257  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y257
Splice isoforms : SwissVarQ9Y257
PhosPhoSitePlusQ9Y257
Domains : Interpro (EBI)2pore_dom_K_chnl    2pore_dom_K_chnl_TASK    2pore_dom_K_chnl_TWIK    2pore_dom_K_chnl_TWIK2    K_chnl_dom   
Domain families : Pfam (Sanger)Ion_trans_2 (PF07885)   
Domain families : Pfam (NCBI)pfam07885   
Conserved Domain (NCBI)KCNK6
DMDM Disease mutations9424
Blocks (Seattle)KCNK6
SuperfamilyQ9Y257
Peptide AtlasQ9Y257
HPRD06803
IPIIPI00031756   IPI00216922   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y257
IntAct (EBI)Q9Y257
BioGRIDKCNK6
STRING (EMBL)KCNK6
ZODIACKCNK6
Ontologies - Pathways
QuickGOQ9Y257
Ontology : AmiGOnegative regulation of systemic arterial blood pressure  inward rectifier potassium channel activity  potassium channel activity  plasma membrane  potassium ion transport  voltage-gated potassium channel complex  regulation of ion transmembrane transport  regulation of resting membrane potential  cardiac conduction  potassium ion transmembrane transport  
Ontology : EGO-EBInegative regulation of systemic arterial blood pressure  inward rectifier potassium channel activity  potassium channel activity  plasma membrane  potassium ion transport  voltage-gated potassium channel complex  regulation of ion transmembrane transport  regulation of resting membrane potential  cardiac conduction  potassium ion transmembrane transport  
NDEx NetworkKCNK6
Atlas of Cancer Signalling NetworkKCNK6
Wikipedia pathwaysKCNK6
Orthology - Evolution
OrthoDB9424
Phylogenetic Trees/Animal Genes : TreeFamKCNK6
HOVERGENQ9Y257
HOGENOMQ9Y257
Homologs : HomoloGeneKCNK6
Homology/Alignments : Family Browser (UCSC)KCNK6
Gene fusions - Rearrangements
Tumor Fusion PortalKCNK6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNK6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNK6
dbVarKCNK6
ClinVarKCNK6
1000_GenomesKCNK6 
Exome Variant ServerKCNK6
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP9424
Genomic Variants (DGV)KCNK6 [DGVbeta]
DECIPHERKCNK6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNK6 
Mutations
ICGC Data PortalKCNK6 
TCGA Data PortalKCNK6 
Broad Tumor PortalKCNK6
OASIS PortalKCNK6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNK6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNK6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNK6
DgiDB (Drug Gene Interaction Database)KCNK6
DoCM (Curated mutations)KCNK6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNK6 (select a term)
intoGenKCNK6
Cancer3DKCNK6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603939   
Orphanet
DisGeNETKCNK6
MedgenKCNK6
Genetic Testing Registry KCNK6
NextProtQ9Y257 [Medical]
TSGene9424
GENETestsKCNK6
Target ValidationKCNK6
Huge Navigator KCNK6 [HugePedia]
snp3D : Map Gene to Disease9424
BioCentury BCIQKCNK6
ClinGenKCNK6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9424
Chemical/Pharm GKB GenePA30063
Clinical trialKCNK6
Miscellaneous
canSAR (ICR)KCNK6 (select the gene name)
Probes
Litterature
< hvef=../extdef.html#PUBMED TARGET=PUBMED>PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNK6
EVEXKCNK6
GoPubMedKCNK6
iHOPKCNK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:38:46 CET 2017

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