Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4)

Identity

Alias_namespotassium large conductance calcium-activated channel, subfamily M, beta member 4
potassium channel subfamily M regulatory beta subunit 4
Other alias-
HGNC (Hugo) KCNMB4
LocusID (NCBI) 27345
Atlas_Id 55506
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 70366282 and ends at 70434292 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLDN11 (3q26.2) / KCNMB4 (12q15)FAM19A2 (12q14.1) / KCNMB4 (12q15)KCNMB4 (12q15) / ALDH3B2 (11q13.2)
KCNMB4 (12q15) / CCND3 (6p21.1)KCNMB4 (12q15) / RTKN2 (10q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNMB4   6289
Cards
Entrez_Gene (NCBI)KCNMB4  27345  potassium calcium-activated channel subfamily M regulatory beta subunit 4
Aliases
GeneCards (Weizmann)KCNMB4
Ensembl hg19 (Hinxton)ENSG00000135643 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135643 [Gene_View]  chr12:70366282-70434292 [Contig_View]  KCNMB4 [Vega]
ICGC DataPortalENSG00000135643
TCGA cBioPortalKCNMB4
AceView (NCBI)KCNMB4
Genatlas (Paris)KCNMB4
WikiGenes27345
SOURCE (Princeton)KCNMB4
Genetics Home Reference (NIH)KCNMB4
Genomic and cartography
GoldenPath hg38 (UCSC)KCNMB4  -     chr12:70366282-70434292 +  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNMB4  -     12q15   [Description]    (hg19-Feb_2009)
EnsemblKCNMB4 - 12q15 [CytoView hg19]  KCNMB4 - 12q15 [CytoView hg38]
Mapping of homologs : NCBIKCNMB4 [Mapview hg19]  KCNMB4 [Mapview hg38]
OMIM605223   
Gene and transcription
Genbank (Entrez)AF160967 AF207992 AF215891 AK054684 BC037898
RefSeq transcript (Entrez)NM_014505
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNMB4
Cluster EST : UnigeneHs.525529 [ NCBI ]
CGAP (NCI)Hs.525529
Alternative Splicing GalleryENSG00000135643
Gene ExpressionKCNMB4 [ NCBI-GEO ]   KCNMB4 [ EBI - ARRAY_EXPRESS ]   KCNMB4 [ SEEK ]   KCNMB4 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNMB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27345
GTEX Portal (Tissue expression)KCNMB4
Human Protein AtlasENSG00000135643-KCNMB4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86W47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86W47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86W47
Splice isoforms : SwissVarQ86W47
PhosPhoSitePlusQ86W47
Domains : Interpro (EBI)K_chnl_Ca-activ_BK_bsu   
Domain families : Pfam (Sanger)CaKB (PF03185)   
Domain families : Pfam (NCBI)pfam03185   
Conserved Domain (NCBI)KCNMB4
DMDM Disease mutations27345
Blocks (Seattle)KCNMB4
SuperfamilyQ86W47
Human Protein Atlas [tissue]ENSG00000135643-KCNMB4 [tissue]
Peptide AtlasQ86W47
HPRD05564
IPIIPI00217101   IPI00976776   
Protein Interaction databases
DIP (DOE-UCLA)Q86W47
IntAct (EBI)Q86W47
FunCoupENSG00000135643
BioGRIDKCNMB4
STRING (EMBL)KCNMB4
ZODIACKCNMB4
Ontologies - Pathways
QuickGOQ86W47
Ontology : AmiGOaction potential  detection of calcium ion  protein binding  plasma membrane  integral component of plasma membrane  potassium ion transport  chemical synaptic transmission  voltage-gated potassium channel complex  calcium-activated potassium channel activity  potassium channel regulator activity  neuronal action potential  regulation of vasoconstriction  regulation of neurotransmitter secretion  regulation of molecular function  potassium ion transmembrane transport  
Ontology : EGO-EBIaction potential  detection of calcium ion  protein binding  plasma membrane  integral component of plasma membrane  potassium ion transport  chemical synaptic transmission  voltage-gated potassium channel complex  calcium-activated potassium channel activity  potassium channel regulator activity  neuronal action potential  regulation of vasoconstriction  regulation of neurotransmitter secretion  regulation of molecular function  potassium ion transmembrane transport  
Pathways : KEGGVascular smooth muscle contraction    Insulin secretion   
NDEx NetworkKCNMB4
Atlas of Cancer Signalling NetworkKCNMB4
Wikipedia pathwaysKCNMB4
Orthology - Evolution
OrthoDB27345
GeneTree (enSembl)ENSG00000135643
Phylogenetic Trees/Animal Genes : TreeFamKCNMB4
HOVERGENQ86W47
HOGENOMQ86W47
Homologs : HomoloGeneKCNMB4
Homology/Alignments : Family Browser (UCSC)KCNMB4
Gene fusions - Rearrangements
Fusion: Tumor Portal KCNMB4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNMB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNMB4
dbVarKCNMB4
ClinVarKCNMB4
1000_GenomesKCNMB4 
Exome Variant ServerKCNMB4
ExAC (Exome Aggregation Consortium)ENSG00000135643
GNOMAD BrowserENSG00000135643
Genetic variants : HAPMAP27345
Genomic Variants (DGV)KCNMB4 [DGVbeta]
DECIPHERKCNMB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNMB4 
Mutations
ICGC Data PortalKCNMB4 
TCGA Data PortalKCNMB4 
Broad Tumor PortalKCNMB4
OASIS PortalKCNMB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNMB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNMB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNMB4
DgiDB (Drug Gene Interaction Database)KCNMB4
DoCM (Curated mutations)KCNMB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNMB4 (select a term)
intoGenKCNMB4
Cancer3DKCNMB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605223   
Orphanet
MedgenKCNMB4
Genetic Testing Registry KCNMB4
NextProtQ86W47 [Medical]
TSGene27345
GENETestsKCNMB4
Target ValidationKCNMB4
Huge Navigator KCNMB4 [HugePedia]
snp3D : Map Gene to Disease27345
BioCentury BCIQKCNMB4
ClinGenKCNMB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27345
Chemical/Pharm GKB GenePA30069
Clinical trialKCNMB4
Miscellaneous
canSAR (ICR)KCNMB4 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNMB4
EVEXKCNMB4
GoPubMedKCNMB4
iHOPKCNMB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:55:13 CET 2017

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