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KCNN1 (potassium calcium-activated channel subfamily N member 1)

Identity

Alias (NCBI)KCa2.1
SK1
SKCA1
hSK1
HGNC (Hugo) KCNN1
HGNC Alias symbKCa2.1
hSK1
HGNC Alias namesmall conductance calcium-activated potassium channel 1
HGNC Previous namepotassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LocusID (NCBI) 3780
Atlas_Id 54397
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 17951302 and ends at 17999121 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARRDC2 (19p13.11) / KCNN1 (19p13.11)DNM2 (19p13.2) / KCNN1 (19p13.11)FAM53B (10q26.13) / KCNN1 (19p13.11)
KCNN1 (19p13.11) / SLC27A1 (19p13.11)ARRDC2 19p13.11 / KCNN1 19p13.11FAM53B 10q26.13 / KCNN1 19p13.11
KCNN1 19p13.11 / SLC27A1 19p13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KCNN1   6290
Cards
Entrez_Gene (NCBI)KCNN1    potassium calcium-activated channel subfamily N member 1
AliasesKCa2.1; SK1; SKCA1; hSK1
GeneCards (Weizmann)KCNN1
Ensembl hg19 (Hinxton)ENSG00000105642 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105642 [Gene_View]  ENSG00000105642 [Sequence]  chr19:17951302-17999121 [Contig_View]  KCNN1 [Vega]
ICGC DataPortalENSG00000105642
TCGA cBioPortalKCNN1
AceView (NCBI)KCNN1
Genatlas (Paris)KCNN1
SOURCE (Princeton)KCNN1
Genetics Home Reference (NIH)KCNN1
Genomic and cartography
GoldenPath hg38 (UCSC)KCNN1  -     chr19:17951302-17999121 +  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNN1  -     19p13.11   [Description]    (hg19-Feb_2009)
GoldenPathKCNN1 - 19p13.11 [CytoView hg19]  KCNN1 - 19p13.11 [CytoView hg38]
ImmunoBaseENSG00000105642
Genome Data Viewer NCBIKCNN1 [Mapview hg19]  
OMIM602982   
Gene and transcription
Genbank (Entrez)AB198191 AK298170 AW594619 BC075037 BE504989
RefSeq transcript (Entrez)NM_001386974 NM_001386975 NM_001386976 NM_001386977 NM_002248
Consensus coding sequences : CCDS (NCBI)KCNN1
Gene ExpressionKCNN1 [ NCBI-GEO ]   KCNN1 [ EBI - ARRAY_EXPRESS ]   KCNN1 [ SEEK ]   KCNN1 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNN1 [ Firebrowse - Broad ]
GenevisibleExpression of KCNN1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3780
GTEX Portal (Tissue expression)KCNN1
Human Protein AtlasENSG00000105642-KCNN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92952   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92952  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92952
PhosPhoSitePlusQ92952
Domains : Interpro (EBI)CaM-bd_dom    CaM-bd_dom_sf    K_chnl_Ca-activ_SK    K_chnl_dom   
Domain families : Pfam (Sanger)CaMBD (PF02888)    Ion_trans_2 (PF07885)    SK_channel (PF03530)   
Domain families : Pfam (NCBI)pfam02888    pfam07885    pfam03530   
Domain families : Smart (EMBL)CaMBD (SM01053)  
Conserved Domain (NCBI)KCNN1
SuperfamilyQ92952
AlphaFold pdb e-kbQ92952   
Human Protein Atlas [tissue]ENSG00000105642-KCNN1 [tissue]
HPRD04282
Protein Interaction databases
DIP (DOE-UCLA)Q92952
IntAct (EBI)Q92952
BioGRIDKCNN1
STRING (EMBL)KCNN1
ZODIACKCNN1
Ontologies - Pathways
QuickGOQ92952
Ontology : AmiGOinward rectifier potassium channel activity  calmodulin binding  plasma membrane  plasma membrane  ion transport  potassium ion transport  chemical synaptic transmission  voltage-gated potassium channel complex  calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  neuron projection  neuronal cell body  synapse  potassium ion transmembrane transport  potassium ion transmembrane transport  positive regulation of potassium ion transmembrane transport  
Ontology : EGO-EBIinward rectifier potassium channel activity  calmodulin binding  plasma membrane  plasma membrane  ion transport  potassium ion transport  chemical synaptic transmission  voltage-gated potassium channel complex  calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  neuron projection  neuronal cell body  synapse  potassium ion transmembrane transport  potassium ion transmembrane transport  positive regulation of potassium ion transmembrane transport  
Pathways : KEGGInsulin secretion   
NDEx NetworkKCNN1
Atlas of Cancer Signalling NetworkKCNN1
Wikipedia pathwaysKCNN1
Orthology - Evolution
OrthoDB3780
GeneTree (enSembl)ENSG00000105642
Phylogenetic Trees/Animal Genes : TreeFamKCNN1
Homologs : HomoloGeneKCNN1
Homology/Alignments : Family Browser (UCSC)KCNN1
Gene fusions - Rearrangements
Fusion : MitelmanARRDC2/KCNN1 [19p13.11/19p13.11]  
Fusion : MitelmanDNM2/KCNN1 [19p13.2/19p13.11]  
Fusion : MitelmanFAM53B/KCNN1 [10q26.13/19p13.11]  
Fusion : MitelmanKCNN1/SLC27A1 [19p13.11/19p13.11]  
Fusion : QuiverKCNN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNN1
dbVarKCNN1
ClinVarKCNN1
MonarchKCNN1
1000_GenomesKCNN1 
Exome Variant ServerKCNN1
GNOMAD BrowserENSG00000105642
Varsome BrowserKCNN1
ACMGKCNN1 variants
VarityQ92952
Genomic Variants (DGV)KCNN1 [DGVbeta]
DECIPHERKCNN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNN1 
Mutations
ICGC Data PortalKCNN1 
TCGA Data PortalKCNN1 
Broad Tumor PortalKCNN1
OASIS PortalKCNN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNN1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKCNN1
Mutations and Diseases : HGMDKCNN1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKCNN1
DgiDB (Drug Gene Interaction Database)KCNN1
DoCM (Curated mutations)KCNN1
CIViC (Clinical Interpretations of Variants in Cancer)KCNN1
Cancer3DKCNN1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602982   
Orphanet
DisGeNETKCNN1
MedgenKCNN1
Genetic Testing Registry KCNN1
NextProtQ92952 [Medical]
GENETestsKCNN1
Target ValidationKCNN1
Huge Navigator KCNN1 [HugePedia]
ClinGenKCNN1
Clinical trials, drugs, therapy
MyCancerGenomeKCNN1
Protein Interactions : CTDKCNN1
Pharm GKB GenePA30070
PharosQ92952
Clinical trialKCNN1
Miscellaneous
canSAR (ICR)KCNN1
HarmonizomeKCNN1
DataMed IndexKCNN1
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKCNN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:45 CEST 2021

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