KCNN2 (potassium calcium-activated channel subfamily N member 2)

2014-11-01  

Identity

HGNC
KCNN2
LOCATION
5q22.3
LOCUSID
3781
ALIAS
KCa2.2,SK2,SKCA2,SKCa 2,hSK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3781
MIM: 605879
HGNC: 6291
Ensembl: ENSG00000080709

Variants:

dbSNP: 3781
ClinVar: 3781
TCGA: ENSG00000080709
COSMIC: KCNN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080709ENST00000264773Q9H2S1
ENSG00000080709ENST00000503706Q9H2S1
ENSG00000080709ENST00000505491D6RGY7
ENSG00000080709ENST00000512097A0A3F2YNY5
ENSG00000080709ENST00000610748Q9H2S1
ENSG00000080709ENST00000631899A0A0J9YW81

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Serotonergic synapseKEGGhsa04726
Insulin secretionKEGGhsa04911
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Ca2+ activated K+ channelsREACTOMER-HSA-1296052

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
136793672003Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts.101
191390402009Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.84
171105932007Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.56
235254372013Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles.36
198155202009Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel).25
153620452004Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels.22
221549082012Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation.20
244345222014Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.16
236770572013Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis.14
163969312006Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein.11

Citation

Dessen P

KCNN2 (potassium calcium-activated channel subfamily N member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64804/kcnn2