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KCNN2 (potassium calcium-activated channel subfamily N member 2)

Identity

Alias_namespotassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
Alias_symbol (synonym)KCa2.2
hSK2
Other aliasSK2
SKCA2
SKCa 2
HGNC (Hugo) KCNN2
LocusID (NCBI) 3781
Atlas_Id 64804
Location 5q22.3  [Link to chromosome band 5q22]
Location_base_pair Starts at 114362319 and ends at 114496500 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APC (5q22.2) / KCNN2 (5q22.3)KCNN2 (5q22.3) / KCNN2 (5q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNN2   6291
Cards
Entrez_Gene (NCBI)KCNN2  3781  potassium calcium-activated channel subfamily N member 2
AliasesKCa2.2; SK2; SKCA2; SKCa; 
hSK2
GeneCards (Weizmann)KCNN2
Ensembl hg19 (Hinxton)ENSG00000080709 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080709 [Gene_View]  chr5:114362319-114496500 [Contig_View]  KCNN2 [Vega]
ICGC DataPortalENSG00000080709
TCGA cBioPortalKCNN2
AceView (NCBI)KCNN2
Genatlas (Paris)KCNN2
WikiGenes3781
SOURCE (Princeton)KCNN2
Genetics Home Reference (NIH)KCNN2
Genomic and cartography
GoldenPath hg38 (UCSC)KCNN2  -     chr5:114362319-114496500 +  5q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNN2  -     5q22.3   [Description]    (hg19-Feb_2009)
EnsemblKCNN2 - 5q22.3 [CytoView hg19]  KCNN2 - 5q22.3 [CytoView hg38]
Mapping of homologs : NCBIKCNN2 [Mapview hg19]  KCNN2 [Mapview hg38]
OMIM605879   
Gene and transcription
Genbank (Entrez)AF239613 AF397175 AK090521 AK289948 AY258141
RefSeq transcript (Entrez)NM_001278204 NM_021614 NM_170775
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNN2
Cluster EST : UnigeneHs.582520 [ NCBI ]
CGAP (NCI)Hs.582520
Alternative Splicing GalleryENSG00000080709
Gene ExpressionKCNN2 [ NCBI-GEO ]   KCNN2 [ EBI - ARRAY_EXPRESS ]   KCNN2 [ SEEK ]   KCNN2 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3781
GTEX Portal (Tissue expression)KCNN2
Human Protein AtlasENSG00000080709-KCNN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2S1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2S1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2S1
Splice isoforms : SwissVarQ9H2S1
PhosPhoSitePlusQ9H2S1
Domains : Interpro (EBI)CaM-bd_dom    K_chnl_Ca-activ_SK    K_chnl_dom   
Domain families : Pfam (Sanger)CaMBD (PF02888)    Ion_trans_2 (PF07885)    SK_channel (PF03530)   
Domain families : Pfam (NCBI)pfam02888    pfam07885    pfam03530   
Domain families : Smart (EMBL)CaMBD (SM01053)  
Conserved Domain (NCBI)KCNN2
DMDM Disease mutations3781
Blocks (Seattle)KCNN2
SuperfamilyQ9H2S1
Human Protein Atlas [tissue]ENSG00000080709-KCNN2 [tissue]
Peptide AtlasQ9H2S1
HPRD09323
IPIIPI00301072   IPI00377145   IPI00965151   IPI00964601   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2S1
IntAct (EBI)Q9H2S1
FunCoupENSG00000080709
BioGRIDKCNN2
STRING (EMBL)KCNN2
ZODIACKCNN2
Ontologies - Pathways
QuickGOQ9H2S1
Ontology : AmiGOprotein binding  calmodulin binding  smooth endoplasmic reticulum  plasma membrane  plasma membrane  potassium ion transport  cell surface  calcium-activated potassium channel activity  integral component of membrane  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  protein domain specific binding  Z disc  T-tubule  protein homodimerization activity  neuronal cell body  dendritic spine  alpha-actinin binding  potassium ion transmembrane transport  potassium ion transmembrane transport  membrane repolarization during atrial cardiac muscle cell action potential  regulation of potassium ion transmembrane transport  
Ontology : EGO-EBIprotein binding  calmodulin binding  smooth endoplasmic reticulum  plasma membrane  plasma membrane  potassium ion transport  cell surface  calcium-activated potassium channel activity  integral component of membrane  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  protein domain specific binding  Z disc  T-tubule  protein homodimerization activity  neuronal cell body  dendritic spine  alpha-actinin binding  potassium ion transmembrane transport  potassium ion transmembrane transport  membrane repolarization during atrial cardiac muscle cell action potential  regulation of potassium ion transmembrane transport  
Pathways : KEGGSerotonergic synapse    Insulin secretion    Bile secretion   
NDEx NetworkKCNN2
Atlas of Cancer Signalling NetworkKCNN2
Wikipedia pathwaysKCNN2
Orthology - Evolution
OrthoDB3781
GeneTree (enSembl)ENSG00000080709
Phylogenetic Trees/Animal Genes : TreeFamKCNN2
HOVERGENQ9H2S1
HOGENOMQ9H2S1
Homologs : HomoloGeneKCNN2
Homology/Alignments : Family Browser (UCSC)KCNN2
Gene fusions - Rearrangements
Tumor Fusion PortalKCNN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNN2
dbVarKCNN2
ClinVarKCNN2
1000_GenomesKCNN2 
Exome Variant ServerKCNN2
ExAC (Exome Aggregation Consortium)ENSG00000080709
GNOMAD BrowserENSG00000080709
Genetic variants : HAPMAP3781
Genomic Variants (DGV)KCNN2 [DGVbeta]
DECIPHERKCNN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNN2 
Mutations
ICGC Data PortalKCNN2 
TCGA Data PortalKCNN2 
Broad Tumor PortalKCNN2
OASIS PortalKCNN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNN2
DgiDB (Drug Gene Interaction Database)KCNN2
DoCM (Curated mutations)KCNN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNN2 (select a term)
intoGenKCNN2
Cancer3DKCNN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605879   
Orphanet
DisGeNETKCNN2
MedgenKCNN2
Genetic Testing Registry KCNN2
NextProtQ9H2S1 [Medical]
TSGene3781
GENETestsKCNN2
Target ValidationKCNN2
Huge Navigator KCNN2 [HugePedia]
snp3D : Map Gene to Disease3781
BioCentury BCIQKCNN2
ClinGenKCNN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3781
Chemical/Pharm GKB GenePA30071
Clinical trialKCNN2
Miscellaneous
canSAR (ICR)KCNN2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNN2
EVEXKCNN2
GoPubMedKCNN2
iHOPKCNN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:11:48 CET 2017

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