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KCNN3 (potassium calcium-activated channel subfamily N member 3)

Identity

Alias_namespotassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
Alias_symbol (synonym)KCa2.3
hSK3
SKCA3
Other aliasSK3
HGNC (Hugo) KCNN3
LocusID (NCBI) 3782
Atlas_Id 51331
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 154697466 and ends at 154859862 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GATAD2B (1q21.3) / KCNN3 (1q21.3)KCNN3 (1q21.3) / ASH1L (1q22)KCNN3 (1q21.3) / DCST2 (1q21.3)
KCNN3 (1q21.3) / PDLIM1 (10q23.33)GATAD2B 1q21.3 / KCNN3 1q21.3KCNN3 1q21.3 / DCST2 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  GATAD2B/KCNN3 (1q21)
t(1;1)(q21;q22) KCNN3/DCST2


External links

Nomenclature
HGNC (Hugo)KCNN3   6292
Cards
Entrez_Gene (NCBI)KCNN3  3782  potassium calcium-activated channel subfamily N member 3
AliasesKCa2.3; SK3; SKCA3; hSK3
GeneCards (Weizmann)KCNN3
Ensembl hg19 (Hinxton)ENSG00000143603 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143603 [Gene_View]  ENSG00000143603 [Sequence]  chr1:154697466-154859862 [Contig_View]  KCNN3 [Vega]
ICGC DataPortalENSG00000143603
TCGA cBioPortalKCNN3
AceView (NCBI)KCNN3
Genatlas (Paris)KCNN3
WikiGenes3782
SOURCE (Princeton)KCNN3
Genetics Home Reference (NIH)KCNN3
Genomic and cartography
GoldenPath hg38 (UCSC)KCNN3  -     chr1:154697466-154859862 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNN3  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblKCNN3 - 1q21.3 [CytoView hg19]  KCNN3 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIKCNN3 [Mapview hg19]  KCNN3 [Mapview hg38]
OMIM602983   
Gene and transcription
Genbank (Entrez)AA284005 AF031815 AF438203 AJ251016 AK310077
RefSeq transcript (Entrez)NM_001204087 NM_001365837 NM_001365838 NM_002249 NM_170782
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNN3
Cluster EST : UnigeneHs.490765 [ NCBI ]
CGAP (NCI)Hs.490765
Alternative Splicing GalleryENSG00000143603
Gene ExpressionKCNN3 [ NCBI-GEO ]   KCNN3 [ EBI - ARRAY_EXPRESS ]   KCNN3 [ SEEK ]   KCNN3 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3782
GTEX Portal (Tissue expression)KCNN3
Human Protein AtlasENSG00000143603-KCNN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGI6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGI6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGI6
Splice isoforms : SwissVarQ9UGI6
PhosPhoSitePlusQ9UGI6
Domains : Interpro (EBI)CaM-bd_dom    CaM-bd_dom_sf    K_chnl_Ca-activ_SK    K_chnl_dom   
Domain families : Pfam (Sanger)CaMBD (PF02888)    Ion_trans_2 (PF07885)    SK_channel (PF03530)   
Domain families : Pfam (NCBI)pfam02888    pfam07885    pfam03530   
Domain families : Smart (EMBL)CaMBD (SM01053)  
Conserved Domain (NCBI)KCNN3
DMDM Disease mutations3782
Blocks (Seattle)KCNN3
SuperfamilyQ9UGI6
Human Protein Atlas [tissue]ENSG00000143603-KCNN3 [tissue]
Peptide AtlasQ9UGI6
HPRD04283
IPIIPI00032465   IPI00395734   IPI00015226   IPI00983227   IPI00514711   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGI6
IntAct (EBI)Q9UGI6
FunCoupENSG00000143603
BioGRIDKCNN3
STRING (EMBL)KCNN3
ZODIACKCNN3
Ontologies - Pathways
QuickGOQ9UGI6
Ontology : AmiGOcalmodulin binding  plasma membrane  plasma membrane  integral component of membrane  small conductance calcium-activated potassium channel activity  neuron projection  neuronal cell body  potassium ion transmembrane transport  
Ontology : EGO-EBIcalmodulin binding  plasma membrane  plasma membrane  integral component of membrane  small conductance calcium-activated potassium channel activity  neuron projection  neuronal cell body  potassium ion transmembrane transport  
Pathways : KEGGInsulin secretion   
NDEx NetworkKCNN3
Atlas of Cancer Signalling NetworkKCNN3
Wikipedia pathwaysKCNN3
Orthology - Evolution
OrthoDB3782
GeneTree (enSembl)ENSG00000143603
Phylogenetic Trees/Animal Genes : TreeFamKCNN3
HOVERGENQ9UGI6
HOGENOMQ9UGI6
Homologs : HomoloGeneKCNN3
Homology/Alignments : Family Browser (UCSC)KCNN3
Gene fusions - Rearrangements
Fusion : MitelmanGATAD2B/KCNN3 [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion : MitelmanKCNN3/DCST2 [1q21.3/1q21.3]  [t(1;1)(q21;q22)]  
Fusion PortalGATAD2B 1q21.3 KCNN3 1q21.3 PRAD
Fusion PortalKCNN3 1q21.3 DCST2 1q21.3 BRCA
Fusion : QuiverKCNN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNN3
dbVarKCNN3
ClinVarKCNN3
1000_GenomesKCNN3 
Exome Variant ServerKCNN3
ExAC (Exome Aggregation Consortium)ENSG00000143603
GNOMAD BrowserENSG00000143603
Varsome BrowserKCNN3
Genetic variants : HAPMAP3782
Genomic Variants (DGV)KCNN3 [DGVbeta]
DECIPHERKCNN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNN3 
Mutations
ICGC Data PortalKCNN3 
TCGA Data PortalKCNN3 
Broad Tumor PortalKCNN3
OASIS PortalKCNN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNN3
DgiDB (Drug Gene Interaction Database)KCNN3
DoCM (Curated mutations)KCNN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNN3 (select a term)
intoGenKCNN3
Cancer3DKCNN3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602983   
Orphanet
DisGeNETKCNN3
MedgenKCNN3
Genetic Testing Registry KCNN3
NextProtQ9UGI6 [Medical]
TSGene3782
GENETestsKCNN3
Target ValidationKCNN3
Huge Navigator KCNN3 [HugePedia]
snp3D : Map Gene to Disease3782
BioCentury BCIQKCNN3
ClinGenKCNN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3782
Chemical/Pharm GKB GenePA30072
Clinical trialKCNN3
Miscellaneous
canSAR (ICR)KCNN3 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNN3
EVEXKCNN3
GoPubMedKCNN3
iHOPKCNN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:14:38 CET 2018

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