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KCNN3 (potassium calcium-activated channel subfamily N member 3)

Identity

Alias (NCBI)KCa2.3
SK3
SKCA3
ZLS3
hSK3
HGNC (Hugo) KCNN3
HGNC Alias symbKCa2.3
hSK3
SKCA3
HGNC Alias namesmall conductance calcium-activated potassium channel 3
HGNC Previous namepotassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
LocusID (NCBI) 3782
Atlas_Id 51331
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 154697458 and ends at 154859876 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GATAD2B (1q21.3) / KCNN3 (1q21.3)KCNN3 (1q21.3) / ASH1L (1q22)KCNN3 (1q21.3) / DCST2 (1q21.3)
KCNN3 (1q21.3) / PDLIM1 (10q23.33)GATAD2B 1q21.3 / KCNN3 1q21.3KCNN3 1q21.3 / DCST2 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KCNN3   6292
Cards
Entrez_Gene (NCBI)KCNN3    potassium calcium-activated channel subfamily N member 3
AliasesKCa2.3; SK3; SKCA3; ZLS3; 
hSK3
GeneCards (Weizmann)KCNN3
Ensembl hg19 (Hinxton)ENSG00000143603 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143603 [Gene_View]  ENSG00000143603 [Sequence]  chr1:154697458-154859876 [Contig_View]  KCNN3 [Vega]
ICGC DataPortalENSG00000143603
TCGA cBioPortalKCNN3
AceView (NCBI)KCNN3
Genatlas (Paris)KCNN3
SOURCE (Princeton)KCNN3
Genetics Home Reference (NIH)KCNN3
Genomic and cartography
GoldenPath hg38 (UCSC)KCNN3  -     chr1:154697458-154859876 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNN3  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathKCNN3 - 1q21.3 [CytoView hg19]  KCNN3 - 1q21.3 [CytoView hg38]
ImmunoBaseENSG00000143603
Genome Data Viewer NCBIKCNN3 [Mapview hg19]  
OMIM602983   618658   
Gene and transcription
Genbank (Entrez)AA284005 AF031815 AF438203 AJ251016 AK310077
RefSeq transcript (Entrez)NM_001204087 NM_001365837 NM_001365838 NM_002249 NM_170782
Consensus coding sequences : CCDS (NCBI)KCNN3
Gene ExpressionKCNN3 [ NCBI-GEO ]   KCNN3 [ EBI - ARRAY_EXPRESS ]   KCNN3 [ SEEK ]   KCNN3 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNN3 [ Firebrowse - Broad ]
GenevisibleExpression of KCNN3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3782
GTEX Portal (Tissue expression)KCNN3
Human Protein AtlasENSG00000143603-KCNN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGI6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGI6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGI6
PhosPhoSitePlusQ9UGI6
Domains : Interpro (EBI)CaM-bd_dom    CaM-bd_dom_sf    K_chnl_Ca-activ_SK    K_chnl_dom   
Domain families : Pfam (Sanger)CaMBD (PF02888)    Ion_trans_2 (PF07885)    SK_channel (PF03530)   
Domain families : Pfam (NCBI)pfam02888    pfam07885    pfam03530   
Domain families : Smart (EMBL)CaMBD (SM01053)  
Conserved Domain (NCBI)KCNN3
SuperfamilyQ9UGI6
AlphaFold pdb e-kbQ9UGI6   
Human Protein Atlas [tissue]ENSG00000143603-KCNN3 [tissue]
HPRD04283
Protein Interaction databases
DIP (DOE-UCLA)Q9UGI6
IntAct (EBI)Q9UGI6
BioGRIDKCNN3
STRING (EMBL)KCNN3
ZODIACKCNN3
Ontologies - Pathways
QuickGOQ9UGI6
Ontology : AmiGOinward rectifier potassium channel activity  calmodulin binding  calmodulin binding  cytoplasm  plasma membrane  plasma membrane  ion transport  integral component of membrane  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  neuron projection  neuronal cell body  potassium ion transmembrane transport  potassium ion transmembrane transport  positive regulation of potassium ion transmembrane transport  
Ontology : EGO-EBIinward rectifier potassium channel activity  calmodulin binding  calmodulin binding  cytoplasm  plasma membrane  plasma membrane  ion transport  integral component of membrane  small conductance calcium-activated potassium channel activity  small conductance calcium-activated potassium channel activity  neuron projection  neuronal cell body  potassium ion transmembrane transport  potassium ion transmembrane transport  positive regulation of potassium ion transmembrane transport  
Pathways : KEGGInsulin secretion   
NDEx NetworkKCNN3
Atlas of Cancer Signalling NetworkKCNN3
Wikipedia pathwaysKCNN3
Orthology - Evolution
OrthoDB3782
GeneTree (enSembl)ENSG00000143603
Phylogenetic Trees/Animal Genes : TreeFamKCNN3
Homologs : HomoloGeneKCNN3
Homology/Alignments : Family Browser (UCSC)KCNN3
Gene fusions - Rearrangements
Fusion : MitelmanGATAD2B/KCNN3 [1q21.3/1q21.3]  
Fusion : MitelmanKCNN3/DCST2 [1q21.3/1q21.3]  
Fusion : QuiverKCNN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNN3
dbVarKCNN3
ClinVarKCNN3
MonarchKCNN3
1000_GenomesKCNN3 
Exome Variant ServerKCNN3
GNOMAD BrowserENSG00000143603
Varsome BrowserKCNN3
ACMGKCNN3 variants
VarityQ9UGI6
Genomic Variants (DGV)KCNN3 [DGVbeta]
DECIPHERKCNN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNN3 
Mutations
ICGC Data PortalKCNN3 
TCGA Data PortalKCNN3 
Broad Tumor PortalKCNN3
OASIS PortalKCNN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNN3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKCNN3
Mutations and Diseases : HGMDKCNN3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKCNN3
DgiDB (Drug Gene Interaction Database)KCNN3
DoCM (Curated mutations)KCNN3
CIViC (Clinical Interpretations of Variants in Cancer)KCNN3
Cancer3DKCNN3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602983    618658   
Orphanet
DisGeNETKCNN3
MedgenKCNN3
Genetic Testing Registry KCNN3
NextProtQ9UGI6 [Medical]
GENETestsKCNN3
Target ValidationKCNN3
Huge Navigator KCNN3 [HugePedia]
ClinGenKCNN3
Clinical trials, drugs, therapy
MyCancerGenomeKCNN3
Protein Interactions : CTDKCNN3
Pharm GKB GenePA30072
PharosQ9UGI6
Clinical trialKCNN3
Miscellaneous
canSAR (ICR)KCNN3
HarmonizomeKCNN3
DataMed IndexKCNN3
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKCNN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:14:45 CEST 2021

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