KCNN4 (potassium calcium-activated channel subfamily N member 4)

2007-10-01  

Identity

HGNC
LOCATION
19q13.31
LOCUSID
ALIAS
DHS2,IK,IK1,IKCA1,KCA4,KCa3.1,SK4,hIKCa1,hKCa4,hSK4
FUSION GENES

Other Information

Locus ID:

NCBI: 3783
MIM: 602754
HGNC: 6293
Ensembl: ENSG00000104783

Variants:

dbSNP: 3783
ClinVar: 3783
TCGA: ENSG00000104783
COSMIC: KCNN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104783ENST00000598836M0R1J0
ENSG00000104783ENST00000599720M0R2F1
ENSG00000104783ENST00000600408M0R2E8
ENSG00000104783ENST00000600909M0QZ70
ENSG00000104783ENST00000615047D1MQ08
ENSG00000104783ENST00000648319O15554

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Insulin secretionKEGGhsa04911
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Ca2+ activated K+ channelsREACTOMER-HSA-1296052

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186882832008The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.89
171572502006Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.70
239492222013KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo.44
187966142008Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1.43
192707242009Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry.37
233452192013Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3.34
175851142007KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation.33
126121942003Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia.32
127736232003The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells.32
185479952008KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease.31

Citation

Dessen P

KCNN4 (potassium calcium-activated channel subfamily N member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49764/kcnn4