Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCNQ4 (potassium voltage-gated channel subfamily Q member 4)

Identity

Alias_namesDFNA2
potassium voltage-gated channel, KQT-like subfamily, member 4
potassium channel, voltage gated KQT-like subfamily Q, member 4
Alias_symbol (synonym)Kv7.4
Other aliasDFNA2A
KV7.4
HGNC (Hugo) KCNQ4
LocusID (NCBI) 9132
Atlas_Id 64807
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 40784012 and ends at 40840452 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCNQ4 (1p34.2) / SNHG1 (11q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KCNQ4   6298
Cards
Entrez_Gene (NCBI)KCNQ4  9132  potassium voltage-gated channel subfamily Q member 4
AliasesDFNA2; DFNA2A; KV7.4
GeneCards (Weizmann)KCNQ4
Ensembl hg19 (Hinxton)ENSG00000117013 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117013 [Gene_View]  chr1:40784012-40840452 [Contig_View]  KCNQ4 [Vega]
ICGC DataPortalENSG00000117013
TCGA cBioPortalKCNQ4
AceView (NCBI)KCNQ4
Genatlas (Paris)KCNQ4
WikiGenes9132
SOURCE (Princeton)KCNQ4
Genetics Home Reference (NIH)KCNQ4
Genomic and cartography
GoldenPath hg38 (UCSC)KCNQ4  -     chr1:40784012-40840452 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNQ4  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblKCNQ4 - 1p34.2 [CytoView hg19]  KCNQ4 - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIKCNQ4 [Mapview hg19]  KCNQ4 [Mapview hg38]
OMIM600101   603537   
Gene and transcription
Genbank (Entrez)AF105202 AK074957 CA411644 DA782056
RefSeq transcript (Entrez)NM_004700 NM_172163
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNQ4
Cluster EST : UnigeneHs.473058 [ NCBI ]
CGAP (NCI)Hs.473058
Alternative Splicing GalleryENSG00000117013
Gene ExpressionKCNQ4 [ NCBI-GEO ]   KCNQ4 [ EBI - ARRAY_EXPRESS ]   KCNQ4 [ SEEK ]   KCNQ4 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNQ4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9132
GTEX Portal (Tissue expression)KCNQ4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56696   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56696  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56696
Splice isoforms : SwissVarP56696
PhosPhoSitePlusP56696
Domains : Interpro (EBI)Ion_trans_dom    K_chnl_volt-dep_KCNQ    K_chnl_volt-dep_KCNQ_C    KCQN4    VG_K_chnl   
Domain families : Pfam (Sanger)Ion_trans (PF00520)    KCNQ_channel (PF03520)   
Domain families : Pfam (NCBI)pfam00520    pfam03520   
Conserved Domain (NCBI)KCNQ4
DMDM Disease mutations9132
Blocks (Seattle)KCNQ4
PDB (SRS)2OVC    4GOW   
PDB (PDBSum)2OVC    4GOW   
PDB (IMB)2OVC    4GOW   
PDB (RSDB)2OVC    4GOW   
Structural Biology KnowledgeBase2OVC    4GOW   
SCOP (Structural Classification of Proteins)2OVC    4GOW   
CATH (Classification of proteins structures)2OVC    4GOW   
SuperfamilyP56696
Human Protein AtlasENSG00000117013
Peptide AtlasP56696
HPRD04641
IPIIPI00293679   IPI00293680   IPI00965399   
Protein Interaction databases
DIP (DOE-UCLA)P56696
IntAct (EBI)P56696
FunCoupENSG00000117013
BioGRIDKCNQ4
STRING (EMBL)KCNQ4
ZODIACKCNQ4
Ontologies - Pathways
QuickGOP56696
Ontology : AmiGOvoltage-gated potassium channel activity  potassium channel activity  protein binding  plasma membrane  potassium ion transport  sensory perception of sound  voltage-gated potassium channel complex  basal plasma membrane  integral component of membrane  regulation of ion transmembrane transport  inner ear morphogenesis  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated potassium channel activity  potassium channel activity  protein binding  plasma membrane  potassium ion transport  sensory perception of sound  voltage-gated potassium channel complex  basal plasma membrane  integral component of membrane  regulation of ion transmembrane transport  inner ear morphogenesis  potassium ion transmembrane transport  
Pathways : BIOCARTAIon Channels and Their Functional Role in Vascular Endothelium [Genes]   
Pathways : KEGGCholinergic synapse   
NDEx NetworkKCNQ4
Atlas of Cancer Signalling NetworkKCNQ4
Wikipedia pathwaysKCNQ4
Orthology - Evolution
OrthoDB9132
GeneTree (enSembl)ENSG00000117013
Phylogenetic Trees/Animal Genes : TreeFamKCNQ4
HOVERGENP56696
HOGENOMP56696
Homologs : HomoloGeneKCNQ4
Homology/Alignments : Family Browser (UCSC)KCNQ4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNQ4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNQ4
dbVarKCNQ4
ClinVarKCNQ4
1000_GenomesKCNQ4 
Exome Variant ServerKCNQ4
ExAC (Exome Aggregation Consortium)KCNQ4 (select the gene name)
Genetic variants : HAPMAP9132
Genomic Variants (DGV)KCNQ4 [DGVbeta]
DECIPHERKCNQ4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNQ4 
Mutations
ICGC Data PortalKCNQ4 
TCGA Data PortalKCNQ4 
Broad Tumor PortalKCNQ4
OASIS PortalKCNQ4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNQ4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNQ4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch KCNQ4
DgiDB (Drug Gene Interaction Database)KCNQ4
DoCM (Curated mutations)KCNQ4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNQ4 (select a term)
intoGenKCNQ4
Cancer3DKCNQ4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600101    603537   
Orphanet12046   
MedgenKCNQ4
Genetic Testing Registry KCNQ4
NextProtP56696 [Medical]
TSGene9132
GENETestsKCNQ4
Huge Navigator KCNQ4 [HugePedia]
snp3D : Map Gene to Disease9132
BioCentury BCIQKCNQ4
ClinGenKCNQ4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9132
Chemical/Pharm GKB GenePA30076
Clinical trialKCNQ4
Miscellaneous
canSAR (ICR)KCNQ4 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNQ4
EVEXKCNQ4
GoPubMedKCNQ4
iHOPKCNQ4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:17:41 CEST 2017

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