Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KCNQ5 (potassium voltage-gated channel subfamily Q member 5)

Identity

Alias_namespotassium voltage-gated channel, KQT-like subfamily, member 5
potassium channel, voltage gated KQT-like subfamily Q, member 5
Alias_symbol (synonym)Kv7.5
Other aliasMRD46
HGNC (Hugo) KCNQ5
LocusID (NCBI) 56479
Atlas_Id 53014
Location 6q13  [Link to chromosome band 6q13]
Location_base_pair Starts at 72621843 and ends at 73198850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRM8 (7q31.33) / KCNQ5 (6q13)KCNQ5 (6q13) / ALK (2p23.2)KCNQ5 (6q13) / DST (6p12.1)
KCNQ5 (6q13) / KCNQ5 (6q13)MTO1 (6q13) / KCNQ5 (6q13)KCNQ5 6q13 / ALK 2p23.2
KCNQ5 6q13 / DST 6p12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;6)(p23;q13) KCNQ5/ALK
t(6;6)(p12;q13) KCNQ5/DST


External links

Nomenclature
HGNC (Hugo)KCNQ5   6299
Cards
Entrez_Gene (NCBI)KCNQ5  56479  potassium voltage-gated channel subfamily Q member 5
AliasesKv7.5; MRD46
GeneCards (Weizmann)KCNQ5
Ensembl hg19 (Hinxton)ENSG00000185760 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185760 [Gene_View]  ENSG00000185760 [Sequence]  chr6:72621843-73198850 [Contig_View]  KCNQ5 [Vega]
ICGC DataPortalENSG00000185760
TCGA cBioPortalKCNQ5
AceView (NCBI)KCNQ5
Genatlas (Paris)KCNQ5
WikiGenes56479
SOURCE (Princeton)KCNQ5
Genetics Home Reference (NIH)KCNQ5
Genomic and cartography
GoldenPath hg38 (UCSC)KCNQ5  -     chr6:72621843-73198850 +  6q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KCNQ5  -     6q13   [Description]    (hg19-Feb_2009)
EnsemblKCNQ5 - 6q13 [CytoView hg19]  KCNQ5 - 6q13 [CytoView hg38]
Mapping of homologs : NCBIKCNQ5 [Mapview hg19]  KCNQ5 [Mapview hg38]
OMIM607357   617601   
Gene and transcription
Genbank (Entrez)AF202977 AF249278 AF263835 AK299550 AK299741
RefSeq transcript (Entrez)NM_001160130 NM_001160132 NM_001160133 NM_001160134 NM_019842
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KCNQ5
Cluster EST : UnigeneHs.445324 [ NCBI ]
CGAP (NCI)Hs.445324
Alternative Splicing GalleryENSG00000185760
Gene ExpressionKCNQ5 [ NCBI-GEO ]   KCNQ5 [ EBI - ARRAY_EXPRESS ]   KCNQ5 [ SEEK ]   KCNQ5 [ MEM ]
Gene Expression Viewer (FireBrowse)KCNQ5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56479
GTEX Portal (Tissue expression)KCNQ5
Human Protein AtlasENSG00000185760-KCNQ5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR82   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR82  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR82
Splice isoforms : SwissVarQ9NR82
PhosPhoSitePlusQ9NR82
Domains : Interpro (EBI)Ion_trans_dom    K_chnl_volt-dep_KCNQ    K_chnl_volt-dep_KCNQ_C    VG_K_chnl   
Domain families : Pfam (Sanger)Ion_trans (PF00520)    KCNQ_channel (PF03520)   
Domain families : Pfam (NCBI)pfam00520    pfam03520   
Conserved Domain (NCBI)KCNQ5
DMDM Disease mutations56479
Blocks (Seattle)KCNQ5
SuperfamilyQ9NR82
Human Protein Atlas [tissue]ENSG00000185760-KCNQ5 [tissue]
Peptide AtlasQ9NR82
HPRD16241
IPIIPI00478577   IPI00473029   IPI00930175   IPI01010809   IPI00935676   IPI00854572   IPI00853593   IPI00853541   IPI00221277   IPI00853354   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR82
IntAct (EBI)Q9NR82
FunCoupENSG00000185760
BioGRIDKCNQ5
STRING (EMBL)KCNQ5
ZODIACKCNQ5
Ontologies - Pathways
QuickGOQ9NR82
Ontology : AmiGOvoltage-gated potassium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  protein binding  calmodulin binding  plasma membrane  integral component of plasma membrane  voltage-gated potassium channel complex  voltage-gated potassium channel complex  integral component of membrane  clathrin coat  regulation of ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  
Ontology : EGO-EBIvoltage-gated potassium channel activity  voltage-gated potassium channel activity  voltage-gated potassium channel activity  delayed rectifier potassium channel activity  protein binding  calmodulin binding  plasma membrane  integral component of plasma membrane  voltage-gated potassium channel complex  voltage-gated potassium channel complex  integral component of membrane  clathrin coat  regulation of ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  potassium ion transmembrane transport  
Pathways : KEGGCholinergic synapse   
NDEx NetworkKCNQ5
Atlas of Cancer Signalling NetworkKCNQ5
Wikipedia pathwaysKCNQ5
Orthology - Evolution
OrthoDB56479
GeneTree (enSembl)ENSG00000185760
Phylogenetic Trees/Animal Genes : TreeFamKCNQ5
HOVERGENQ9NR82
HOGENOMQ9NR82
Homologs : HomoloGeneKCNQ5
Homology/Alignments : Family Browser (UCSC)KCNQ5
Gene fusions - Rearrangements
Fusion : MitelmanKCNQ5/ALK [6q13/2p23.2]  
Fusion : MitelmanKCNQ5/DST [6q13/6p12.1]  [t(6;6)(p12;q13)]  
Fusion PortalKCNQ5 6q13 ALK 2p23.2 SKCM
Fusion PortalKCNQ5 6q13 DST 6p12.1 LUSC
Fusion : QuiverKCNQ5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCNQ5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCNQ5
dbVarKCNQ5
ClinVarKCNQ5
1000_GenomesKCNQ5 
Exome Variant ServerKCNQ5
ExAC (Exome Aggregation Consortium)ENSG00000185760
GNOMAD BrowserENSG00000185760
Varsome BrowserKCNQ5
Genetic variants : HAPMAP56479
Genomic Variants (DGV)KCNQ5 [DGVbeta]
DECIPHERKCNQ5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKCNQ5 
Mutations
ICGC Data PortalKCNQ5 
TCGA Data PortalKCNQ5 
Broad Tumor PortalKCNQ5
OASIS PortalKCNQ5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCNQ5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCNQ5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCNQ5
DgiDB (Drug Gene Interaction Database)KCNQ5
DoCM (Curated mutations)KCNQ5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCNQ5 (select a term)
intoGenKCNQ5
Cancer3DKCNQ5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607357    617601   
Orphanet
DisGeNETKCNQ5
MedgenKCNQ5
Genetic Testing Registry KCNQ5
NextProtQ9NR82 [Medical]
TSGene56479
GENETestsKCNQ5
Target ValidationKCNQ5
Huge Navigator KCNQ5 [HugePedia]
snp3D : Map Gene to Disease56479
BioCentury BCIQKCNQ5
ClinGenKCNQ5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56479
Chemical/Pharm GKB GenePA30077
Clinical trialKCNQ5
Miscellaneous
canSAR (ICR)KCNQ5 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCNQ5
EVEXKCNQ5
GoPubMedKCNQ5
iHOPKCNQ5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:14:40 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.