KCTD10 (potassium channel tetramerization domain containing 10)

2015-02-01 Affiliation

Identity

HGNC

KCTD10

LOCATION

12q24.11

LOCUSID

83892

ALIAS

BTBD28,MSTP028,ULRO61,hBACURD3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 83892
MIM: 613421
HGNC: 23236
Ensembl: ENSG00000110906

Variants:

dbSNP: 83892
ClinVar: 83892
TCGA: ENSG00000110906
COSMIC: KCTD10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000110906	ENST00000228495	Q9H3F6
ENSG00000110906	ENST00000228495	A0A024RBJ2
ENSG00000110906	ENST00000440541	F8W8I7
ENSG00000110906	ENST00000535546	F5GWK6
ENSG00000110906	ENST00000537165	S4R3L9
ENSG00000110906	ENST00000540089	B3KVY5
ENSG00000110906	ENST00000540355	F5GY15
ENSG00000110906	ENST00000540411	F5GWA4
ENSG00000110906	ENST00000541077	S4R3Y7
ENSG00000110906	ENST00000542262	F5H6V0
ENSG00000110906	ENST00000542858	F5H497
ENSG00000110906	ENST00000542954	F5H268

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
20570916	2010	Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.	17
19125419	2009	KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation.	12
19605566	2009	Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.	9
19605566	2009	Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.	9
23977394	2013	Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor.	9
19154347	2009	Transcription factor specificity protein 1 (SP1) and activating protein 2alpha (AP-2alpha) regulate expression of human KCTD10 gene by binding to proximal region of promoter.	8
30515933	2019	Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells.	8
29358211	2018	The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.	7
22810651	2012	TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1.	6

Citation

Dessen P

KCTD10 (potassium channel tetramerization domain containing 10)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55029/kctd10