KCTD15 (potassium channel tetramerization domain containing 15)

2014-11-01  

Identity

HGNC
KCTD15
LOCATION
19q13.11
LOCUSID
79047
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79047
MIM: 615240
HGNC: 23297
Ensembl: ENSG00000153885

Variants:

dbSNP: 79047
ClinVar: 79047
TCGA: ENSG00000153885
COSMIC: KCTD15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153885ENST00000284006Q96SI1
ENSG00000153885ENST00000430256Q96SI1
ENSG00000153885ENST00000587559K7EN63
ENSG00000153885ENST00000587658K7EM48
ENSG00000153885ENST00000588637K7EQS3
ENSG00000153885ENST00000588881Q96SI1
ENSG00000153885ENST00000589786Q96SI1
ENSG00000153885ENST00000590385V9GYY8
ENSG00000153885ENST00000590771K7EIF1
ENSG00000153885ENST00000590906K7EPF0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
Negative regulation of activity of TFAP2 (AP-2) family transcription factorsREACTOMER-HSA-8866904

References

Pubmed IDYearTitleCitations
190792612009Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.700
191643862009Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.104
196924902009Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.77
198121712010Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.74
205208482010Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.70
207245812010Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.47
202153972010Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.44
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
198513402009Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.37
205717542010Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.26

Citation

Dessen P

KCTD15 (potassium channel tetramerization domain containing 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64820/kctd15