Atlas of Genetics and Cytogenetics in Oncology and Haematology


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KCTD8 (potassium channel tetramerization domain containing 8)

Identity

Alias_namespotassium channel tetramerisation domain containing 8
Other alias-
HGNC (Hugo) KCTD8
LocusID (NCBI) 386617
Atlas_Id 53259
Location 4p13  [Link to chromosome band 4p13]
Location_base_pair Starts at 44175920 and ends at 44450824 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ART3 (4q21.1) / KCTD8 (4p13)SGMS1 (10q11.23) / KCTD8 (4p13)TOMM70 (3q12.2) / KCTD8 (4p13)
TOMM70A 3q12.2 / KCTD8 4p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)KCTD8   22394
Cards
Entrez_Gene (NCBI)KCTD8  386617  potassium channel tetramerization domain containing 8
Aliases
GeneCards (Weizmann)KCTD8
Ensembl hg19 (Hinxton)ENSG00000183783 [Gene_View]  chr4:44175920-44450824 [Contig_View]  KCTD8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000183783 [Gene_View]  chr4:44175920-44450824 [Contig_View]  KCTD8 [Vega]
ICGC DataPortalENSG00000183783
TCGA cBioPortalKCTD8
AceView (NCBI)KCTD8
Genatlas (Paris)KCTD8
WikiGenes386617
SOURCE (Princeton)KCTD8
Genetics Home Reference (NIH)KCTD8
Genomic and cartography
GoldenPath hg19 (UCSC)KCTD8  -     chr4:44175920-44450824 -  4p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KCTD8  -     4p13   [Description]    (hg38-Dec_2013)
EnsemblKCTD8 - 4p13 [CytoView hg19]  KCTD8 - 4p13 [CytoView hg38]
Mapping of homologs : NCBIKCTD8 [Mapview hg19]  KCTD8 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK123347 AK298831 BC132743 BC136793 DB561746
RefSeq transcript (Entrez)NM_198353
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006238 NW_004929317
Consensus coding sequences : CCDS (NCBI)KCTD8
Cluster EST : UnigeneHs.479644 [ NCBI ]
CGAP (NCI)Hs.479644
Alternative Splicing GalleryENSG00000183783
Gene ExpressionKCTD8 [ NCBI-GEO ]   KCTD8 [ EBI - ARRAY_EXPRESS ]   KCTD8 [ SEEK ]   KCTD8 [ MEM ]
Gene Expression Viewer (FireBrowse)KCTD8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)386617
GTEX Portal (Tissue expression)KCTD8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZWB6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZWB6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZWB6
Splice isoforms : SwissVarQ6ZWB6
PhosPhoSitePlusQ6ZWB6
Domains : Interpro (EBI)BTB/POZ_dom    SKP1/BTB/POZ    T1-type_BTB   
Domain families : Pfam (Sanger)BTB_2 (PF02214)   
Domain families : Pfam (NCBI)pfam02214   
Domain families : Smart (EMBL)BTB (SM00225)  
Conserved Domain (NCBI)KCTD8
DMDM Disease mutations386617
Blocks (Seattle)KCTD8
SuperfamilyQ6ZWB6
Human Protein AtlasENSG00000183783
Peptide AtlasQ6ZWB6
HPRD13771
IPIIPI00383585   IPI00966855   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZWB6
IntAct (EBI)Q6ZWB6
FunCoupENSG00000183783
BioGRIDKCTD8
STRING (EMBL)KCTD8
ZODIACKCTD8
Ontologies - Pathways
QuickGOQ6ZWB6
Ontology : AmiGOregulation of G-protein coupled receptor protein signaling pathway  cell junction  presynaptic membrane  receptor complex  postsynaptic membrane  protein homooligomerization  
Ontology : EGO-EBIregulation of G-protein coupled receptor protein signaling pathway  cell junction  presynaptic membrane  receptor complex  postsynaptic membrane  protein homooligomerization  
NDEx NetworkKCTD8
Atlas of Cancer Signalling NetworkKCTD8
Wikipedia pathwaysKCTD8
Orthology - Evolution
OrthoDB386617
GeneTree (enSembl)ENSG00000183783
Phylogenetic Trees/Animal Genes : TreeFamKCTD8
HOVERGENQ6ZWB6
HOGENOMQ6ZWB6
Homologs : HomoloGeneKCTD8
Homology/Alignments : Family Browser (UCSC)KCTD8
Gene fusions - Rearrangements
Fusion : MitelmanSGMS1/KCTD8 [10q11.23/4p13]  [t(4;10)(p13;q11)]  
Fusion : MitelmanTOMM70A/KCTD8 [3q12.2/4p13]  [t(3;4)(q12;p13)]  
Fusion: TCGATOMM70A 3q12.2 KCTD8 4p13 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKCTD8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KCTD8
dbVarKCTD8
ClinVarKCTD8
1000_GenomesKCTD8 
Exome Variant ServerKCTD8
ExAC (Exome Aggregation Consortium)KCTD8 (select the gene name)
Genetic variants : HAPMAP386617
Genomic Variants (DGV)KCTD8 [DGVbeta]
DECIPHER (Syndromes)4:44175920-44450824  ENSG00000183783
CONAN: Copy Number AnalysisKCTD8 
Mutations
ICGC Data PortalKCTD8 
TCGA Data PortalKCTD8 
Broad Tumor PortalKCTD8
OASIS PortalKCTD8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKCTD8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKCTD8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KCTD8
DgiDB (Drug Gene Interaction Database)KCTD8
DoCM (Curated mutations)KCTD8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KCTD8 (select a term)
intoGenKCTD8
Cancer3DKCTD8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenKCTD8
Genetic Testing Registry KCTD8
NextProtQ6ZWB6 [Medical]
TSGene386617
GENETestsKCTD8
Huge Navigator KCTD8 [HugePedia]
snp3D : Map Gene to Disease386617
BioCentury BCIQKCTD8
ClinGenKCTD8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD386617
Chemical/Pharm GKB GenePA134909779
Clinical trialKCTD8
Miscellaneous
canSAR (ICR)KCTD8 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKCTD8
EVEXKCTD8
GoPubMedKCTD8
iHOPKCTD8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:05:59 CEST 2017

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