KDELR1 (KDEL endoplasmic reticulum protein retention receptor 1)

2014-11-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
ERD2,ERD2.1,HDEL,PM23
FUSION GENES

Other Information

Locus ID:

NCBI: 10945
MIM: 131235
HGNC: 6304
Ensembl: ENSG00000105438

Variants:

dbSNP: 10945
ClinVar: 10945
TCGA: ENSG00000105438
COSMIC: KDELR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105438ENST00000330720P24390
ENSG00000105438ENST00000597017P24390
ENSG00000105438ENST00000600980M0R1Y2

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Vibrio cholerae infectionKEGGko05110
Vibrio cholerae infectionKEGGhsa05110
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128216502003The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades.38
129753822003Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum.36
225808212012The KDEL receptor couples to Gαq/11 to activate Src kinases and regulate transport through the Golgi.36
251176812014Control systems of membrane transport at the interface between the endoplasmic reticulum and the Golgi.34
223635042012Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking.16
216843232011The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins.15
256828662015A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.11
238732872013Regulation of Golgi signaling and trafficking by the KDEL receptor.10
307607042019KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover.5
260648972015Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling.3

Citation

Dessen P

KDELR1 (KDEL endoplasmic reticulum protein retention receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64833/kdelr1