KDM2A (lysine demethylase 2A)

2003-08-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
CXXC8,FBL11,FBL7,FBXL11,JHDM1A,LILINA
FUSION GENES

Other Information

Locus ID:

NCBI: 22992
MIM: 605657
HGNC: 13606
Ensembl: ENSG00000173120

Variants:

dbSNP: 22992
ClinVar: 22992
TCGA: ENSG00000173120
COSMIC: KDM2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173120ENST00000308783I3VM54
ENSG00000173120ENST00000398645Q9Y2K7
ENSG00000173120ENST00000529006Q9Y2K7
ENSG00000173120ENST00000529006I3VM53
ENSG00000173120ENST00000530342Q9Y2K7

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212516132011Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.828
204175972010CpG islands recruit a histone H3 lysine 36 demethylase.134
200807982010Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.101
242006912013KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.52
190018772008KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.43
198053032009Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.41
203791342010JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation.39
230740942013Demethylation of epiregulin gene by histone demethylase FBXL11 and BCL6 corepressor inhibits osteo/dentinogenic differentiation.27
258230242016ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.21
260045082015Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin.21

Citation

Dessen P

KDM2A (lysine demethylase 2A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40540/kdm2a