KDM2B (lysine demethylase 2B)

2013-03-01 Affiliation

Identity

HGNC

KDM2B

LOCATION

12q24.31

LOCUSID

84678

ALIAS

CXXC2,FBXL10,Fbl10,JHDM1B,PCCX2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84678
MIM: 609078
HGNC: 13610
Ensembl: ENSG00000089094

Variants:

dbSNP: 84678
ClinVar: 84678
TCGA: ENSG00000089094
COSMIC: KDM2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000089094	ENST00000377069	Q8NHM5
ENSG00000089094	ENST00000377071	Q8NHM5
ENSG00000089094	ENST00000446152	F8WBN2
ENSG00000089094	ENST00000536437	F6SRV7
ENSG00000089094	ENST00000538046	S4R3G4
ENSG00000089094	ENST00000538379	F5H4A7
ENSG00000089094	ENST00000539394	F5GXC2
ENSG00000089094	ENST00000541318	F5H5W7
ENSG00000089094	ENST00000541511	F5H7T7
ENSG00000089094	ENST00000542030	F5H4X4
ENSG00000089094	ENST00000542973	A0A0C4DGG3
ENSG00000089094	ENST00000543025	F5H0A1
ENSG00000089094	ENST00000543852	F5GXW2
ENSG00000089094	ENST00000545022	F5H6N6
ENSG00000089094	ENST00000611216	Q8NHM5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HDMs demethylate histones	REACTOME	R-HSA-3214842

References

Pubmed ID	Year	Title	Citations
23256043	2012	KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.	145
17994099	2007	JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.	89
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
23321669	2013	KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.	62
24853546	2014	NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.	26
26808549	2016	Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.	23
26004508	2015	Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin.	21
21252908	2011	F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway.	20
22825849	2012	The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts.	20
29502955	2018	The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma.	20

Citation

Dessen P

KDM2B (lysine demethylase 2B)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53197/kdm2b