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KDM4A (lysine demethylase 4A)

Identity

Alias (NCBI)JHDM3A
JMJD2
JMJD2A
TDRD14A
HGNC (Hugo) KDM4A
HGNC Alias symbKIAA0677
JHDM3A
TDRD14A
HGNC Alias namejumonji C domain-containing histone demethylase 3A
 tudor domain containing 14A
HGNC Previous nameJMJD2
 JMJD2A
HGNC Previous namejumonji domain containing 2
 jumonji domain containing 2A
 lysine (K)-specific demethylase 4A
LocusID (NCBI) 9682
Atlas_Id 50835
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 43650149 and ends at 43705518 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KDM4A (1p34.1)::AKR1B1 (7q33)KDM4A (1p34.1)::CREB3L4 (1q21.3)KDM4A (1p34.1)::CSE1L (20q13.13)
KDM4A (1p34.1)::HYI (1p34.2)KDM4A (1p34.1)::KDM4A (1p34.1)KDM4A (1p34.1)::PNKD (2q35)
KDM4A (1p34.1)::PTPRF (1p34.2)KDM4A (1p34.1)::RYBP (3p13)KDM4A 1p34.1::CREB3L4 1q21.3
KDM4A 1p34.1::HYI 1p34.2KDM4A 1p34.1::PTPRF 1p34.2KDM4A 1p34.1::RYBP 3p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KDM4A   22978
Cards
Entrez_Gene (NCBI)KDM4A    lysine demethylase 4A
AliasesJHDM3A; JMJD2; JMJD2A; TDRD14A
GeneCards (Weizmann)KDM4A
Ensembl hg19 (Hinxton)ENSG00000066135 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066135 [Gene_View]  ENSG00000066135 [Sequence]  chr1:43650149-43705518 [Contig_View]  KDM4A [Vega]
ICGC DataPortalENSG00000066135
TCGA cBioPortalKDM4A
AceView (NCBI)KDM4A
Genatlas (Paris)KDM4A
SOURCE (Princeton)KDM4A
Genetics Home Reference (NIH)KDM4A
Genomic and cartography
GoldenPath hg38 (UCSC)KDM4A  -     chr1:43650149-43705518 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KDM4A  -     1p34.2   [Description]    (hg19-Feb_2009)
GoldenPathKDM4A - 1p34.2 [CytoView hg19]  KDM4A - 1p34.2 [CytoView hg38]
ImmunoBaseENSG00000066135
Genome Data Viewer NCBIKDM4A [Mapview hg19]  
OMIM609764   
Gene and transcription
Genbank (Entrez)AB014577 AK294596 AK300039 AK310295 BC002558
RefSeq transcript (Entrez)NM_014663
Consensus coding sequences : CCDS (NCBI)KDM4A
Gene ExpressionKDM4A [ NCBI-GEO ]   KDM4A [ EBI - ARRAY_EXPRESS ]   KDM4A [ SEEK ]   KDM4A [ MEM ]
Gene Expression Viewer (FireBrowse)KDM4A [ Firebrowse - Broad ]
GenevisibleExpression of KDM4A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9682
GTEX Portal (Tissue expression)KDM4A
Human Protein AtlasENSG00000066135-KDM4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75164   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75164  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75164
PhosPhoSitePlusO75164
Domaine pattern : Prosite (Expaxy)EPHD (PS51805)    JMJC (PS51184)    JMJN (PS51183)   
Domains : Interpro (EBI)EPHD    JmjC_dom    JmjN    KDM4_Tudor_2    Tudor    Znf_FYVE_PHD    Znf_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)JmjC (PF02373)    JmjN (PF02375)    Tudor_2 (PF18104)   
Domain families : Pfam (NCBI)pfam02373    pfam02375    pfam18104   
Domain families : Smart (EMBL)JmjC (SM00558)  JmjN (SM00545)  PHD (SM00249)  TUDOR (SM00333)  
Conserved Domain (NCBI)KDM4A
PDB (RSDB)2GF7    2GFA    2GP3    2GP5    2OQ6    2OQ7    2OS2    2OT7    2OX0    2P5B    2PXJ    2Q8C    2Q8D    2Q8E    2QQR    2QQS    2VD7    2WWJ    2YBK    2YBP    2YBS    3NJY    3PDQ    3RVH    3U4S    4AI9    4BIS    4GD4    4URA    4V2V    4V2W    5A7N    5A7O    5A7P    5A7Q    5A7S    5A7W    5A80    5ANQ    5D6W    5D6X    5D6Y    5F2S    5F2W    5F32    5F37    5F39    5F3C    5F3E    5F3G    5F3I    5F5I    5FPV    5FWE    5FY8    5FYC    5FYH    5FYI    5LY1    5LY2    5TVR    5TVS    5VAR    5VGI    5VMP    6CG1    6CG2    6G5W    6G5X    6H4O    6H4P    6H4Q    6H4R    6H4S    6H4T    6H4U    6H4V    6H4W    6H4X    6H4Y    6H8P    6HGT    7D4A   
PDB Europe2GF7    2GFA    2GP3    2GP5    2OQ6    2OQ7    2OS2    2OT7    2OX0    2P5B    2PXJ    2Q8C    2Q8D    2Q8E    2QQR    2QQS    2VD7    2WWJ    2YBK    2YBP    2YBS    3NJY    3PDQ    3RVH    3U4S    4AI9    4BIS    4GD4    4URA    4V2V    4V2W    5A7N    5A7O    5A7P    5A7Q    5A7S    5A7W    5A80    5ANQ    5D6W    5D6X    5D6Y    5F2S    5F2W    5F32    5F37    5F39    5F3C    5F3E    5F3G    5F3I    5F5I    5FPV    5FWE    5FY8    5FYC    5FYH    5FYI    5LY1    5LY2    5TVR    5TVS    5VAR    5VGI    5VMP    6CG1    6CG2    6G5W    6G5X    6H4O    6H4P    6H4Q    6H4R    6H4S    6H4T    6H4U    6H4V    6H4W    6H4X    6H4Y    6H8P    6HGT    7D4A   
PDB (PDBSum)2GF7    2GFA    2GP3    2GP5    2OQ6    2OQ7    2OS2    2OT7    2OX0    2P5B    2PXJ    2Q8C    2Q8D    2Q8E    2QQR    2QQS    2VD7    2WWJ    2YBK    2YBP    2YBS    3NJY    3PDQ    3RVH    3U4S    4AI9    4BIS    4GD4    4URA    4V2V    4V2W    5A7N    5A7O    5A7P    5A7Q    5A7S    5A7W    5A80    5ANQ    5D6W    5D6X    5D6Y    5F2S    5F2W    5F32    5F37    5F39    5F3C    5F3E    5F3G    5F3I    5F5I    5FPV    5FWE    5FY8    5FYC    5FYH    5FYI    5LY1    5LY2    5TVR    5TVS    5VAR    5VGI    5VMP    6CG1    6CG2    6G5W    6G5X    6H4O    6H4P    6H4Q    6H4R    6H4S    6H4T    6H4U    6H4V    6H4W    6H4X    6H4Y    6H8P    6HGT    7D4A   
PDB (IMB)2GF7    2GFA    2GP3    2GP5    2OQ6    2OQ7    2OS2    2OT7    2OX0    2P5B    2PXJ    2Q8C    2Q8D    2Q8E    2QQR    2QQS    2VD7    2WWJ    2YBK    2YBP    2YBS    3NJY    3PDQ    3RVH    3U4S    4AI9    4BIS    4GD4    4URA    4V2V    4V2W    5A7N    5A7O    5A7P    5A7Q    5A7S    5A7W    5A80    5ANQ    5D6W    5D6X    5D6Y    5F2S    5F2W    5F32    5F37    5F39    5F3C    5F3E    5F3G    5F3I    5F5I    5FPV    5FWE    5FY8    5FYC    5FYH    5FYI    5LY1    5LY2    5TVR    5TVS    5VAR    5VGI    5VMP    6CG1    6CG2    6G5W    6G5X    6H4O    6H4P    6H4Q    6H4R    6H4S    6H4T    6H4U    6H4V    6H4W    6H4X    6H4Y    6H8P    6HGT    7D4A   
Structural Biology KnowledgeBase2GF7    2GFA    2GP3    2GP5    2OQ6    2OQ7    2OS2    2OT7    2OX0    2P5B    2PXJ    2Q8C    2Q8D    2Q8E    2QQR    2QQS    2VD7    2WWJ    2YBK    2YBP    2YBS    3NJY    3PDQ    3RVH    3U4S    4AI9    4BIS    4GD4    4URA    4V2V    4V2W    5A7N    5A7O    5A7P    5A7Q    5A7S    5A7W    5A80    5ANQ    5D6W    5D6X    5D6Y    5F2S    5F2W    5F32    5F37    5F39    5F3C    5F3E    5F3G    5F3I    5F5I    5FPV    5FWE    5FY8    5FYC    5FYH    5FYI    5LY1    5LY2    5TVR    5TVS    5VAR    5VGI    5VMP    6CG1    6CG2    6G5W    6G5X    6H4O    6H4P    6H4Q    6H4R    6H4S    6H4T    6H4U    6H4V    6H4W    6H4X    6H4Y    6H8P    6HGT    7D4A   
SCOP (Structural Classification of Proteins)2GF7    2GFA    2GP3    2GP5    2OQ6    2OQ7    2OS2    2OT7    2OX0    2P5B    2PXJ    2Q8C    2Q8D    2Q8E    2QQR    2QQS    2VD7    2WWJ    2YBK    2YBP    2YBS    3NJY    3PDQ    3RVH    3U4S    4AI9    4BIS    4GD4    4URA    4V2V    4V2W    5A7N    5A7O    5A7P    5A7Q    5A7S    5A7W    5A80    5ANQ    5D6W    5D6X    5D6Y    5F2S    5F2W    5F32    5F37    5F39    5F3C    5F3E    5F3G    5F3I    5F5I    5FPV    5FWE    5FY8    5FYC    5FYH    5FYI    5LY1    5LY2    5TVR    5TVS    5VAR    5VGI    5VMP    6CG1    6CG2    6G5W    6G5X    6H4O    6H4P    6H4Q    6H4R    6H4S    6H4T    6H4U    6H4V    6H4W    6H4X    6H4Y    6H8P    6HGT    7D4A   
CATH (Classification of proteins structures)2GF7    2GFA    2GP3    2GP5    2OQ6    2OQ7    2OS2    2OT7    2OX0    2P5B    2PXJ    2Q8C    2Q8D    2Q8E    2QQR    2QQS    2VD7    2WWJ    2YBK    2YBP    2YBS    3NJY    3PDQ    3RVH    3U4S    4AI9    4BIS    4GD4    4URA    4V2V    4V2W    5A7N    5A7O    5A7P    5A7Q    5A7S    5A7W    5A80    5ANQ    5D6W    5D6X    5D6Y    5F2S    5F2W    5F32    5F37    5F39    5F3C    5F3E    5F3G    5F3I    5F5I    5FPV    5FWE    5FY8    5FYC    5FYH    5FYI    5LY1    5LY2    5TVR    5TVS    5VAR    5VGI    5VMP    6CG1    6CG2    6G5W    6G5X    6H4O    6H4P    6H4Q    6H4R    6H4S    6H4T    6H4U    6H4V    6H4W    6H4X    6H4Y    6H8P    6HGT    7D4A   
SuperfamilyO75164
AlphaFold pdb e-kbO75164   
Human Protein Atlas [tissue]ENSG00000066135-KDM4A [tissue]
HPRD17168
Protein Interaction databases
DIP (DOE-UCLA)O75164
IntAct (EBI)O75164
BioGRIDKDM4A
STRING (EMBL)KDM4A
ZODIACKDM4A
Ontologies - Pathways
QuickGOO75164
Ontology : AmiGOfibrillar center  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  pericentric heterochromatin  cytosol  double-strand break repair  chromatin remodeling  zinc ion binding  negative regulation of autophagy  positive regulation of gene expression  negative regulation of gene expression  cardiac muscle hypertrophy in response to stress  histone demethylation  intracellular receptor signaling pathway  ubiquitin protein ligase binding  response to nutrient levels  histone demethylase activity  histone demethylase activity (H3-K9 specific)  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  methylated histone binding  positive regulation of neuron differentiation  negative regulation of transcription, DNA-templated  negative regulation of astrocyte differentiation  histone demethylase activity (H3-K36 specific)  histone demethylase activity (H3-K36 specific)  negative regulation of cell death  histone H3-K36 demethylation  negative regulation of histone H3-K9 trimethylation  
Ontology : EGO-EBIfibrillar center  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  pericentric heterochromatin  cytosol  double-strand break repair  chromatin remodeling  zinc ion binding  negative regulation of autophagy  positive regulation of gene expression  negative regulation of gene expression  cardiac muscle hypertrophy in response to stress  histone demethylation  intracellular receptor signaling pathway  ubiquitin protein ligase binding  response to nutrient levels  histone demethylase activity  histone demethylase activity (H3-K9 specific)  histone demethylase activity (H3-K9 specific)  histone H3-K9 demethylation  methylated histone binding  positive regulation of neuron differentiation  negative regulation of transcription, DNA-templated  negative regulation of astrocyte differentiation  histone demethylase activity (H3-K36 specific)  histone demethylase activity (H3-K36 specific)  negative regulation of cell death  histone H3-K36 demethylation  negative regulation of histone H3-K9 trimethylation  
NDEx NetworkKDM4A
Atlas of Cancer Signalling NetworkKDM4A
Wikipedia pathwaysKDM4A
Orthology - Evolution
OrthoDB9682
GeneTree (enSembl)ENSG00000066135
Phylogenetic Trees/Animal Genes : TreeFamKDM4A
Homologs : HomoloGeneKDM4A
Homology/Alignments : Family Browser (UCSC)KDM4A
Gene fusions - Rearrangements
Fusion : MitelmanKDM4A::CREB3L4 [1p34.1/1q21.3]  
Fusion : MitelmanKDM4A::HYI [1p34.1/1p34.2]  
Fusion : MitelmanKDM4A::PNKD [1p34.1/2q35]  
Fusion : MitelmanKDM4A::PTPRF [1p34.1/1p34.2]  
Fusion : MitelmanKDM4A::RYBP [1p34.1/3p13]  
Fusion : QuiverKDM4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKDM4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KDM4A
dbVarKDM4A
ClinVarKDM4A
MonarchKDM4A
1000_GenomesKDM4A 
Exome Variant ServerKDM4A
GNOMAD BrowserENSG00000066135
Varsome BrowserKDM4A
ACMGKDM4A variants
VarityO75164
Genomic Variants (DGV)KDM4A [DGVbeta]
DECIPHERKDM4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKDM4A 
Mutations
ICGC Data PortalKDM4A 
TCGA Data PortalKDM4A 
Broad Tumor PortalKDM4A
OASIS PortalKDM4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKDM4A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKDM4A
Mutations and Diseases : HGMDKDM4A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKDM4A
DgiDB (Drug Gene Interaction Database)KDM4A
DoCM (Curated mutations)KDM4A
CIViC (Clinical Interpretations of Variants in Cancer)KDM4A
Cancer3DKDM4A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609764   
Orphanet
DisGeNETKDM4A
MedgenKDM4A
Genetic Testing Registry KDM4A
NextProtO75164 [Medical]
GENETestsKDM4A
Target ValidationKDM4A
Huge Navigator KDM4A [HugePedia]
ClinGenKDM4A
Clinical trials, drugs, therapy
MyCancerGenomeKDM4A
Protein Interactions : CTDKDM4A
Pharm GKB GenePA164721403
PharosO75164
Clinical trialKDM4A
Miscellaneous
canSAR (ICR)KDM4A
HarmonizomeKDM4A
ARCHS4KDM4A
DataMed IndexKDM4A
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKDM4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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