KDM4A (lysine demethylase 4A)

2009-04-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
JHDM3A,JMJD2,JMJD2A,TDRD14A
FUSION GENES

Other Information

Locus ID:

NCBI: 9682
MIM: 609764
HGNC: 22978
Ensembl: ENSG00000066135

Variants:

dbSNP: 9682
ClinVar: 9682
TCGA: ENSG00000066135
COSMIC: KDM4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066135ENST00000372396O75164
ENSG00000066135ENST00000463151A0A2R8YDF7
ENSG00000066135ENST00000485249A0A2R8Y7L1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167322922006The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.239
166011532006Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A.177
223735792012RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.147
175895012007Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.121
175895232007Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.108
180843062008Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.93
238716962013KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.86
175557122007Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.74
191446452009Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.69
215558542011The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.64

Citation

Dessen P

KDM4A (lysine demethylase 4A)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50835/kdm4a