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KDM4C (Gene amplified in squamous cell carcinoma 1)

Written2002-12Zeng-Quan Yang
University of Michigan, Department of Radiation Oncology, RM. 7121 CCGC, 1500 E Med Ctr. Dr., Ann Arbor, MI 48109-0948, USA

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)JMJD2C
GASC1 (Gene amplified in squamous cell carcinoma 1)
KIAA0780
HGNC (Hugo) KDM4C
HGNC Alias symbGASC1
KIAA0780
TDRD14C
HGNC Alias nametudor domain containing 14C
HGNC Previous nameJMJD2C
HGNC Previous namejumonji domain containing 2C
 lysine (K)-specific demethylase 4C
LocusID (NCBI) 23081
Atlas_Id 432
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 6757973 and ends at 7175648 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping KDM4C.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KCMF1 (2p11.2)::KDM4C (9p24.1)KDM4C (9p24.1)::ARMC2 (6q21)KDM4C (9p24.1)::JAK2 (9p24.1)
KDM4C (9p24.1)::KLK7 (19q13.41)KDM4C (9p24.1)::MEIS1 (2p14)KDM4C (9p24.1)::PARD6G (18q23)
KDM4C (9p24.1)::PTPRD (9p24.1)KDM4C (9p24.1)::RFX3 (9p24.2)NSD2 (4p16.3)::KDM4C (9p24.1)
PGPEP1 (19p13.11)::KDM4C (9p24.1)SRSF9 (12q24.31)::KDM4C (9p24.1)STPG1 (1p36.11)::KDM4C (9p24.1)

DNA/RNA

Note At least 22 exons spanning approximately 417194 bps. 4239 bp mRNA; coding sequence: 3171 bp

Protein

Description 1056 ammino acid; possesses PHD domain

Implicated in

Note
  
Entity amplification and overexpression in cell lines derived from esophageal squamous cell carcinomas
  

Bibliography

A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.
Yang ZQ, Imoto I, Pimkhaokham A, Shimada Y, Sasaki K, Oka M, Inazawa J
Japanese journal of cancer research : Gann. 2001 ; 92 (4) : 423-428.
PMID 11346465
 

Citation

This paper should be referenced as such :
Yang, ZQ
GASC1 (gene amplified in squamous cell carcinoma 1)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(1):21-21.
Free journal version : [ pdf ]   [ DOI ]


External links

Nomenclature
HGNC (Hugo)KDM4C   17071
Cards
AtlasGASC1ID432
Entrez_Gene (NCBI)KDM4C    lysine demethylase 4C
AliasesGASC1; JHDM3C; JMJD2C; TDRD14C
GeneCards (Weizmann)KDM4C
Ensembl hg19 (Hinxton)ENSG00000107077 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107077 [Gene_View]  ENSG00000107077 [Sequence]  chr9:6757973-7175648 [Contig_View]  KDM4C [Vega]
ICGC DataPortalENSG00000107077
TCGA cBioPortalKDM4C
AceView (NCBI)KDM4C
Genatlas (Paris)KDM4C
SOURCE (Princeton)KDM4C
Genetics Home Reference (NIH)KDM4C
Genomic and cartography
GoldenPath hg38 (UCSC)KDM4C  -     chr9:6757973-7175648 +  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KDM4C  -     9p24.1   [Description]    (hg19-Feb_2009)
GoldenPathKDM4C - 9p24.1 [CytoView hg19]  KDM4C - 9p24.1 [CytoView hg38]
ImmunoBaseENSG00000107077
Genome Data Viewer NCBIKDM4C [Mapview hg19]  
OMIM605469   
Gene and transcription
Genbank (Entrez)AB018323 AB037901 AF085959 AI017056 AI969877
RefSeq transcript (Entrez)NM_001146694 NM_001146695 NM_001146696 NM_001304339 NM_001304340 NM_001304341 NM_001353997 NM_001353998 NM_001353999 NM_001354000 NM_001354001 NM_015061
Consensus coding sequences : CCDS (NCBI)KDM4C
Gene ExpressionKDM4C [ NCBI-GEO ]   KDM4C [ EBI - ARRAY_EXPRESS ]   KDM4C [ SEEK ]   KDM4C [ MEM ]
Gene Expression Viewer (FireBrowse)KDM4C [ Firebrowse - Broad ]
GenevisibleExpression of KDM4C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23081
GTEX Portal (Tissue expression)KDM4C
Human Protein AtlasENSG00000107077-KDM4C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)KDM4C
Human Protein Atlas [tissue]ENSG00000107077-KDM4C [tissue]
HPRD12016
Protein Interaction databases
BioGRIDKDM4C
STRING (EMBL)KDM4C
ZODIACKDM4C
Ontologies - Pathways
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKDM4C
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:18:36 CEST 2021

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